Journal ArticleDOI
Tracing the cellular origin of cancer
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TLDR
This review explores how mouse genetic lineage-tracing experiments that allow the expression of oncogenes and/or the deletion of tumour suppressor genes in defined cell lineages have been instrumental in defining the cellular origin of different solid tumours in mouse models for various human cancers.Abstract:
Although many genes that lead to different types of cancer when mutated have been identified, the cells that initiate tumour formation following accumulation of these mutations have, until recently, remained elusive. This review explores how mouse genetic lineage-tracing experiments that allow the expression of oncogenes and/or the deletion of tumour suppressor genes in defined cell lineages have been instrumental in defining the cellular origin of different solid tumours in mouse models for various human cancers.read more
Citations
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Journal ArticleDOI
Tell me about your stemness. I'll give your cancer risk!
Kiarash Khosrotehrani,Edwige Roy +1 more
TL;DR: A model where a cell-intrinsic factor, defined as the generative capacity in a tissue, can greatly influence tumour formation is proposed, arguing that most cancers are related to the life-long replicative activity of a given tissue’s stem cells.
Dissertation
Epidermal stem cells in physiological tissue regeneration, wound healing and cancer
TL;DR: Tracking the fate of Lgr5and Lgr6-expressing epidermal stem cells during homeostasis, wound healing and early cancer formation shed light on the similarities and differences between distinct stem cell populations in the skin.
Dissertation
Papel del receptor huérfano GPR55 en la fisiopatología del cáncer : implicación en la proliferación e invasión de células tumorales
TL;DR: It is found that GPR55 is expressed in human tumors from different origins, and that this expression is higher in the transformed tissues as compared with the corresponding non-transformed tissues and correlates with tumoriveness.
Journal ArticleDOI
Comparative lineage tracing reveals cellular preferences for prostate cancer initiation.
Zhu A. Wang,Michael M. Shen +1 more
TL;DR: The interplay of different cell types of origin and distinct oncogenic mutations may determine the tumor subtype and it is found that although both basal and luminal epithelial cells can initiate prostate tumorigenesis, the latter are more likely to undergo transformation in response to a range of oncogens.
References
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Journal ArticleDOI
Hallmarks of cancer: the next generation.
TL;DR: Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer.
Journal ArticleDOI
Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008.
TL;DR: The results for 20 world regions are presented, summarizing the global patterns for the eight most common cancers, and striking differences in the patterns of cancer from region to region are observed.
Journal ArticleDOI
Lessons from Hereditary Colorectal Cancer
TL;DR: The authors are grateful to the members of their laboratories for their contributions to the reviewed studies and to F. Giardiello and S. Hamilton for photographs of colorectal lesions.
Journal ArticleDOI
Identification of stem cells in small intestine and colon by marker gene Lgr5
Nick Barker,Johan H. van Es,Jeroen Kuipers,Pekka Kujala,Maaike van den Born,Miranda Cozijnsen,Andrea Haegebarth,Jeroen Korving,Harry Begthel,Peter J. Peters,Hans Clevers +10 more
TL;DR: The expression pattern of Lgr5 suggests that it marks stem cells in multiple adult tissues and cancers, suggesting that it represents the stem cell of the small intestine and colon.