Journal ArticleDOI
Tracing the cellular origin of cancer
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TLDR
This review explores how mouse genetic lineage-tracing experiments that allow the expression of oncogenes and/or the deletion of tumour suppressor genes in defined cell lineages have been instrumental in defining the cellular origin of different solid tumours in mouse models for various human cancers.Abstract:
Although many genes that lead to different types of cancer when mutated have been identified, the cells that initiate tumour formation following accumulation of these mutations have, until recently, remained elusive. This review explores how mouse genetic lineage-tracing experiments that allow the expression of oncogenes and/or the deletion of tumour suppressor genes in defined cell lineages have been instrumental in defining the cellular origin of different solid tumours in mouse models for various human cancers.read more
Citations
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Demonstration of CRISPR/Cas9/sgRNA-mediated targeted gene modification in Arabidopsis, tobacco, sorghum and rice
TL;DR: Adaptations of the type II CRISPR/Cas system leading to successful expression of the Cas9/sgRNA system in model plant and crop species bodes well for its near-term use as a facile and powerful means of plant genetic engineering for scientific and agricultural applications.
Journal ArticleDOI
Unravelling cancer stem cell potential
Benjamin Beck,Cédric Blanpain +1 more
TL;DR: In this Opinion article, the different parallels that can be drawn between adult SCs and CSCs in solid tumours are discussed.
Journal ArticleDOI
Dedifferentiation of committed epithelial cells into stem cells in vivo
Purushothama Rao Tata,Hongmei Mou,Ana Pardo-Saganta,Rui Zhao,Mythili Prabhu,Brandon M. Law,Vladimir Vinarsky,Josalyn L. Cho,Sylvie Breton,Amar Sahay,Benjamin D. Medoff,Jayaraj Rajagopal +11 more
TL;DR: Evidence is presented that differentiated airway epithelial cells can revert into stable and functional stem cells in vivo, and this capacity of committed cells to dedifferentiate into stem cells may have a more general role in the regeneration of many tissues and in multiple disease states, notably cancer.
Journal ArticleDOI
Cancer Stem Cells: Basic Concepts and Therapeutic Implications
Dany Nassar,Cédric Blanpain +1 more
TL;DR: This review discusses how the concept of CSCs has been defined, what assays are currently used to define the functional properties of C SCs, what intrinsic and extrinsic mechanisms regulate CSC functions, how plastic CSC's are, and the importance of epithelial-to-mesenchymal transition in conferring CSC properties.
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Defining the Hallmarks of Metastasis
Danny R. Welch,Douglas R. Hurst +1 more
TL;DR: By defining these first principles of metastasis, this review identifies four distinguishing features that are required: motility and invasion, ability to modulate the secondary site or local microenvironments, plasticity, and ability to colonize secondary tissues.
References
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Journal ArticleDOI
Epithelial Progenitor Cells in Lung Development, Maintenance, Repair, and Disease
Jason R. Rock,Brigid L.M. Hogan +1 more
TL;DR: The development, maintenance, and repair of the vertebrate respiratory system is reviewed with an emphasis on the roles of epithelial stem and progenitor cells.
Journal ArticleDOI
Epidermal stem cells arise from the hair follicle after wounding
TL;DR: It is concluded that follicular cells can undergo reprogramming to become long‐term repopulating epidermal progenitors following wounding and that their progeny persist in wound epidermis for months after the wound is healed.
Journal ArticleDOI
Identification of the cell lineage at the origin of basal cell carcinoma
Khalil Kass Youssef,Alexandra Van Keymeulen,Gaeelle Lapouge,Benjamin Beck,Cindy Michaux,Younes Achouri,Panagiota A. Sotiropoulou,Cédric Blanpain +7 more
TL;DR: Using clonal analysis, it is found that BCC arises from long-term resident progenitor cells of the interfollicular epidermis and the upper infundibulum, and does not originate from bulge stem cells, as previously thought.
Journal ArticleDOI
Genetic predisposition directs breast cancer phenotype by dictating progenitor cell fate
Theresa A. Proia,Patricia J. Keller,Patricia J. Keller,Piyush Gupta,Ina Klebba,Ina Klebba,Ainsley D. Jones,Ainsley D. Jones,Maja Sedic,Maja Sedic,Hannah Leah Gilmore,Nadine Tung,Stephen P. Naber,Stuart J. Schnitt,Eric S. Lander,Eric S. Lander,Charlotte Kuperwasser,Charlotte Kuperwasser +17 more
TL;DR: It is reported here that breast epithelial cells derived from patients harboring deleterious mutations in BRCA1 (BRCA 1(mut /+) give rise to tumors with increased basal differentiation relative to cells from BRCa1+/+ patients.
Journal ArticleDOI
Contribution of stem cells and differentiated cells to epidermal tumours
David M. Owens,Fiona M. Watt +1 more
TL;DR: The outer covering of the skin — the epidermis — is subject to sustained environmental assaults, as a result, many cells acquire potentially oncogenic mutations.