Journal ArticleDOI
Tracing the cellular origin of cancer
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TLDR
This review explores how mouse genetic lineage-tracing experiments that allow the expression of oncogenes and/or the deletion of tumour suppressor genes in defined cell lineages have been instrumental in defining the cellular origin of different solid tumours in mouse models for various human cancers.Abstract:
Although many genes that lead to different types of cancer when mutated have been identified, the cells that initiate tumour formation following accumulation of these mutations have, until recently, remained elusive. This review explores how mouse genetic lineage-tracing experiments that allow the expression of oncogenes and/or the deletion of tumour suppressor genes in defined cell lineages have been instrumental in defining the cellular origin of different solid tumours in mouse models for various human cancers.read more
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Chemotherapy activates cancer-associated fibroblasts to maintain colorectal cancer-initiating cells by IL-17A
Fiorenza Lotti,Awad Jarrar,Rish K. Pai,Masahiro Hitomi,Masahiro Hitomi,Justin D. Lathia,Justin D. Lathia,A.G. Mace,Gerald Gantt,Kumar Sukhdeo,Jennifer DeVecchio,Amit Vasanji,Patrick Leahy,Anita B. Hjelmeland,Matthew F. Kalady,Matthew F. Kalady,Jeremy N. Rich,Jeremy N. Rich +17 more
TL;DR: Chemotherapy stimulates cancer-associated fibroblasts to secrete interleukin-17A to provide maintenance cues to support the growth of colorectal cancer-initiating cells.
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Stemness in Cancer: Stem Cells, Cancer Stem Cells, and Their Microenvironment
Pedro M. Aponte,Andrés Caicedo +1 more
TL;DR: This review will explore properties shared between normal and malignant Stem Cells, including Mesenchymal Stem/Stromal Cells (MSCs), which, although their stemness properties are limited, represent essential components of the Stem Cell niche and tumor microenvironment.
Journal ArticleDOI
Unravelling biology and shifting paradigms in cancer with single-cell sequencing.
Timour Baslan,James W. Hicks +1 more
TL;DR: It is argued that the rapidly evolving field of single-cell sequencing has unshackled the cancer research community of these shortcomings and promises to unravel the biology of all facets of this disease.
Journal ArticleDOI
Cancer heterogeneity—a multifaceted view
TL;DR: It is of utmost importance to understand the biological causes that distinguish tumours as well as distinct tumour cell populations within malignancies, as these will ultimately point the way to more rational anti‐cancer treatments.
Journal ArticleDOI
Cellular origin of bladder neoplasia and tissue dynamics of its progression to invasive carcinoma
Kunyoo Shin,Agnes Lim,Justin I. Odegaard,Jared Honeycutt,Sally Kawano,Michael H. Hsieh,Philip A. Beachy +6 more
TL;DR: It is found that invasive carcinoma is initiated from basal urothelial stem cells but that tumour cell phenotype can diverge significantly from that of the cancer cell of origin.
References
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Journal ArticleDOI
Hallmarks of cancer: the next generation.
TL;DR: Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer.
Journal ArticleDOI
Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008.
TL;DR: The results for 20 world regions are presented, summarizing the global patterns for the eight most common cancers, and striking differences in the patterns of cancer from region to region are observed.
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Lessons from Hereditary Colorectal Cancer
TL;DR: The authors are grateful to the members of their laboratories for their contributions to the reviewed studies and to F. Giardiello and S. Hamilton for photographs of colorectal lesions.
Journal ArticleDOI
Identification of stem cells in small intestine and colon by marker gene Lgr5
Nick Barker,Johan H. van Es,Jeroen Kuipers,Pekka Kujala,Maaike van den Born,Miranda Cozijnsen,Andrea Haegebarth,Jeroen Korving,Harry Begthel,Peter J. Peters,Hans Clevers +10 more
TL;DR: The expression pattern of Lgr5 suggests that it marks stem cells in multiple adult tissues and cancers, suggesting that it represents the stem cell of the small intestine and colon.