Journal ArticleDOI
Tracing the cellular origin of cancer
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TLDR
This review explores how mouse genetic lineage-tracing experiments that allow the expression of oncogenes and/or the deletion of tumour suppressor genes in defined cell lineages have been instrumental in defining the cellular origin of different solid tumours in mouse models for various human cancers.Abstract:
Although many genes that lead to different types of cancer when mutated have been identified, the cells that initiate tumour formation following accumulation of these mutations have, until recently, remained elusive. This review explores how mouse genetic lineage-tracing experiments that allow the expression of oncogenes and/or the deletion of tumour suppressor genes in defined cell lineages have been instrumental in defining the cellular origin of different solid tumours in mouse models for various human cancers.read more
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Differentiation and Inflammation: 'Best Enemies' in Gastrointestinal Carcinogenesis
TL;DR: It is proposed that chronic inflammatory diseases, such as colitis and pancreatitis, predispose to gastrointestinal (GI) adenocarcinoma by reprogramming differentiated cells, and differentiation-targeted treatments hold promise as a therapeutic strategy in GI cancer.
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Krt5 + /Krt15 + foregut basal progenitors give rise to cyclooxygenase-2-dependent tumours in response to gastric acid stress
TL;DR: It is shown that gastric acid stress stimulates tumour formation from a defined tumour-competent Krt5 + /Krt15+foregut basal progenitor cell population, suggesting that clinical management of microenvironmental stressor-mediated microscopic injury may be important in delaying tumor initiation from foreguts basal progensitor cells expressing pre-existing tumorigenic mutation and genetic alteration.
Journal ArticleDOI
Conserved and variable: Understanding mammary stem cells across species.
TL;DR: Identification and comparison of MaSC across a large variety of species, particularly those with extreme lactational adaptations or low mammary cancer incidence, is expected to deepen the understanding of development and malignancy in the mammary gland.
Journal ArticleDOI
Comparison of surgical methods of transient middle cerebral artery occlusion between rats and mice.
TL;DR: The authors' methods could induce stable moderate-severity ischemic brain injury models and histological alteration at 24 hr after MCAo surgery, and approximately 80% (rats) and 85% (mice) survival ratios were shown indicating with model engineering success.
Journal ArticleDOI
Biotinylated polyurethane-urea nanoparticles for targeted theranostics in human hepatocellular carcinoma
Genoveva Morral-Ruíz,Pedro Melgar-Lesmes,Andrea López-Vicente,Conxita Solans,María José García-Celma +4 more
TL;DR: The developed biotinylated polyurethane-urea nanoparticles as theranostic nanocarriers for targeted drug and plasmid delivery, for fluorescence detection of human hepatocellular carcinoma cells, are described herein.
References
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Journal ArticleDOI
Hallmarks of cancer: the next generation.
TL;DR: Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer.
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Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008.
TL;DR: The results for 20 world regions are presented, summarizing the global patterns for the eight most common cancers, and striking differences in the patterns of cancer from region to region are observed.
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Lessons from Hereditary Colorectal Cancer
TL;DR: The authors are grateful to the members of their laboratories for their contributions to the reviewed studies and to F. Giardiello and S. Hamilton for photographs of colorectal lesions.
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Identification of stem cells in small intestine and colon by marker gene Lgr5
Nick Barker,Johan H. van Es,Jeroen Kuipers,Pekka Kujala,Maaike van den Born,Miranda Cozijnsen,Andrea Haegebarth,Jeroen Korving,Harry Begthel,Peter J. Peters,Hans Clevers +10 more
TL;DR: The expression pattern of Lgr5 suggests that it marks stem cells in multiple adult tissues and cancers, suggesting that it represents the stem cell of the small intestine and colon.