Journal ArticleDOI
Tracing the cellular origin of cancer
Reads0
Chats0
TLDR
This review explores how mouse genetic lineage-tracing experiments that allow the expression of oncogenes and/or the deletion of tumour suppressor genes in defined cell lineages have been instrumental in defining the cellular origin of different solid tumours in mouse models for various human cancers.Abstract:
Although many genes that lead to different types of cancer when mutated have been identified, the cells that initiate tumour formation following accumulation of these mutations have, until recently, remained elusive. This review explores how mouse genetic lineage-tracing experiments that allow the expression of oncogenes and/or the deletion of tumour suppressor genes in defined cell lineages have been instrumental in defining the cellular origin of different solid tumours in mouse models for various human cancers.read more
Citations
More filters
Dissertation
Elucidating the role of TGFβ signalling in drug resistant Hh driven cancers
TL;DR: Interestingly, Hh antagonist treatment was associated with increased TGF β signalling activity as evidenced through nuclear accumulation of pSMAD3 and expression of TGFβ regulated genes, and may provide a mechanism through which tumours can promote relapse following treatment, and in rarer cases, induce transformation to more aggressive phenotypes such as SCC.
Journal ArticleDOI
Single-Cell Epigenomics Reveals Mechanisms of Cancer Progression
TL;DR: These single-cell analyses suggest that cells diversify in their regulatory states upon transformation by co-opting damage-induced and nonlineage regulatory programs that can lead to epigenomic plasticity.
Book ChapterDOI
Cancer diagnosis by biosensor-based devices: types and challenges
TL;DR: This chapter considers some of the currently available biosensors’ presently used diagnostic and prognostic tools for cancer development and gives details and theoretical insights into their current research trends, along with advantages and disadvantages.
Journal ArticleDOI
Adult stem cells and other cancer residents. Part II
Eugene D. Sverdlov,V. V. Pleshkan,I. V. Alekseenko,Tatyana V. Vinogradova,E. P. Kopantsev,D. A. Didych +5 more
TL;DR: The present review is an attempt to summarize the recent data on adult stem cells which, according to the present dominant paradigm, most probably can be predisposed to cancer development, or in which cancer is initiated.
MonographDOI
Cancer and cancer stem cell targeting agents : A focus on salinomycin and apoptin
TL;DR: Current cancer treatments involving surgery, radiotherapy, and chemotherapy target the vast majority of cancer cells, but they are only partially effective in eliminating the disease.
References
More filters
Journal ArticleDOI
Hallmarks of cancer: the next generation.
TL;DR: Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer.
Journal ArticleDOI
Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008.
TL;DR: The results for 20 world regions are presented, summarizing the global patterns for the eight most common cancers, and striking differences in the patterns of cancer from region to region are observed.
Journal ArticleDOI
Lessons from Hereditary Colorectal Cancer
TL;DR: The authors are grateful to the members of their laboratories for their contributions to the reviewed studies and to F. Giardiello and S. Hamilton for photographs of colorectal lesions.
Journal ArticleDOI
Identification of stem cells in small intestine and colon by marker gene Lgr5
Nick Barker,Johan H. van Es,Jeroen Kuipers,Pekka Kujala,Maaike van den Born,Miranda Cozijnsen,Andrea Haegebarth,Jeroen Korving,Harry Begthel,Peter J. Peters,Hans Clevers +10 more
TL;DR: The expression pattern of Lgr5 suggests that it marks stem cells in multiple adult tissues and cancers, suggesting that it represents the stem cell of the small intestine and colon.