Journal ArticleDOI
Tracing the cellular origin of cancer
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TLDR
This review explores how mouse genetic lineage-tracing experiments that allow the expression of oncogenes and/or the deletion of tumour suppressor genes in defined cell lineages have been instrumental in defining the cellular origin of different solid tumours in mouse models for various human cancers.Abstract:
Although many genes that lead to different types of cancer when mutated have been identified, the cells that initiate tumour formation following accumulation of these mutations have, until recently, remained elusive. This review explores how mouse genetic lineage-tracing experiments that allow the expression of oncogenes and/or the deletion of tumour suppressor genes in defined cell lineages have been instrumental in defining the cellular origin of different solid tumours in mouse models for various human cancers.read more
Citations
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Demonstration of CRISPR/Cas9/sgRNA-mediated targeted gene modification in Arabidopsis, tobacco, sorghum and rice
TL;DR: Adaptations of the type II CRISPR/Cas system leading to successful expression of the Cas9/sgRNA system in model plant and crop species bodes well for its near-term use as a facile and powerful means of plant genetic engineering for scientific and agricultural applications.
Journal ArticleDOI
Unravelling cancer stem cell potential
Benjamin Beck,Cédric Blanpain +1 more
TL;DR: In this Opinion article, the different parallels that can be drawn between adult SCs and CSCs in solid tumours are discussed.
Journal ArticleDOI
Dedifferentiation of committed epithelial cells into stem cells in vivo
Purushothama Rao Tata,Hongmei Mou,Ana Pardo-Saganta,Rui Zhao,Mythili Prabhu,Brandon M. Law,Vladimir Vinarsky,Josalyn L. Cho,Sylvie Breton,Amar Sahay,Benjamin D. Medoff,Jayaraj Rajagopal +11 more
TL;DR: Evidence is presented that differentiated airway epithelial cells can revert into stable and functional stem cells in vivo, and this capacity of committed cells to dedifferentiate into stem cells may have a more general role in the regeneration of many tissues and in multiple disease states, notably cancer.
Journal ArticleDOI
Cancer Stem Cells: Basic Concepts and Therapeutic Implications
Dany Nassar,Cédric Blanpain +1 more
TL;DR: This review discusses how the concept of CSCs has been defined, what assays are currently used to define the functional properties of C SCs, what intrinsic and extrinsic mechanisms regulate CSC functions, how plastic CSC's are, and the importance of epithelial-to-mesenchymal transition in conferring CSC properties.
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Defining the Hallmarks of Metastasis
Danny R. Welch,Douglas R. Hurst +1 more
TL;DR: By defining these first principles of metastasis, this review identifies four distinguishing features that are required: motility and invasion, ability to modulate the secondary site or local microenvironments, plasticity, and ability to colonize secondary tissues.
References
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Journal ArticleDOI
Defining the origins of Ras/p53-mediated squamous cell carcinoma
Andrew C. White,Kathy V. Tran,Joan Khuu,Christine Dang,Yongyan Cui,Scott W. Binder,William E. Lowry +6 more
TL;DR: Data demonstrate that SCCs can originate from inside the hair follicle stem cell (SC) niche or from immediate progenitors, whereas more developmentally restricted progeny, the transit amplifying (TA) cells, are unable to generate even benign tumors in the same genetic context.
Journal ArticleDOI
Patched1 functions as a gatekeeper by promoting cell cycle progression.
TL;DR: The data suggest that Ptch1 likely functions as a tumor suppressor by inhibiting G1-S phase and G2-M phase cell cycle progression, and the rapid onset of tumor progression clearly indicates Ptch 1 functions as an "gatekeeper."
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Phenotypic characterization of BRCA1 and BRCA2 tumors based in a tissue microarray study with 37 immunohistochemical markers.
José Palacios,Emiliano Honrado,Ana Osorio,Alicia Cazorla,David Sarrió,Alicia Barroso,Sandra Rodríguez,Juan C. Cigudosa,Orland Diez,Carmen Alonso,Enrique Lerma,Joaquín Dopazo,Carmen Rivas,Javier Benitez +13 more
TL;DR: The study in hereditary breast cancer tumors analyzing 37 immunohistochemical markers defines the molecular differences between BRCA1 and BRCa2 tumors with respect to hormonal receptors, cell cycle, apoptosis and basal cell markers.
Journal ArticleDOI
The malignant capacity of skin tumours induced by expression of a mutant H-ras transgene depends on the cell type targeted
TL;DR: Benign tumours that are at a risk of malignant conversion are primarily derived from cells located within the hair follicle, and the nature of the cell in which tumour initiation occurs is a major determinant of malign potential.