Journal ArticleDOI
Tracing the cellular origin of cancer
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TLDR
This review explores how mouse genetic lineage-tracing experiments that allow the expression of oncogenes and/or the deletion of tumour suppressor genes in defined cell lineages have been instrumental in defining the cellular origin of different solid tumours in mouse models for various human cancers.Abstract:
Although many genes that lead to different types of cancer when mutated have been identified, the cells that initiate tumour formation following accumulation of these mutations have, until recently, remained elusive. This review explores how mouse genetic lineage-tracing experiments that allow the expression of oncogenes and/or the deletion of tumour suppressor genes in defined cell lineages have been instrumental in defining the cellular origin of different solid tumours in mouse models for various human cancers.read more
Citations
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Journal ArticleDOI
Stiehopus japonieus acidic mucopolysaccharide inhibits the proliferation of pancreatic cancer SW1990 cells through Hippo-YAP pathway.
Xiaoyu Li,Yi Liu,Cui-Ping Zhang,Qinghui Niu,Hui Wang,Cong Che,Man Xie,Bin Zhou,Yonghong Xu,Qi Zhang,Jun Wu,Zibin Tian +11 more
TL;DR: YAP expression was identified by immunohistochemistry and quantitative Real-time PCR from 45 pairs of human pancreatic ductal adenocarcinoma tissues and their adjacent non-tumor samples and it was found that the YAPexpression was associated with the histological differentiation degree, and negatively correlated with pancreatic cancer patients’ survival.
Journal ArticleDOI
Stem cells in genetically-engineered mouse models of prostate cancer
Maho Shibata,Michael M. Shen +1 more
TL;DR: It is suggested that cancer stem cells capable of tumor propagation exist at various stages of tumor progression from prostatic intraepithelial neoplasia (PIN) to advanced metastatic and castration-resistant disease.
Journal ArticleDOI
Asymmetric Cell Division and Template DNA Co-Segregation in Cancer Stem Cells
Sharon R. Pine,Wenyu Liu +1 more
TL;DR: The role of p53 loss in maintaining self-renewal in both normal and malignant cells is discussed and the mechanisms underlying co-segregation of template DNA strands and the stem-cell pathways associated with it in normal and CSCs are reviewed.
Journal ArticleDOI
Systematic genome sequence differences among leaf cells within individual trees
Deepti Diwan,Shun Komazaki,Miho Suzuki,Naoto Nemoto,Takuyo Aita,Akiko Satake,Koichi Nishigaki +6 more
TL;DR: The genomic distance between two cells within an individual organism was non-negligible, and was correlated with physical distance (i.e., branch-to-branch distance), implying that the degree of divergence is proportional to the number of generations separating the two cells.
Book ChapterDOI
Systems Medicine in Oncology: Signaling Network Modeling and New-Generation Decision-Support Systems.
Silvio Parodi,Giuseppe Riccardi,Nicoletta Castagnino,Lorenzo Tortolina,Massimo E. Maffei,Gabriele Zoppoli,Alessio Nencioni,Alberto Ballestrero,Franco Patrone +8 more
TL;DR: The present level of artificial intelligence (AI) sophistication and the continuous feeding, updating, and integration of cancer-related new data, in AI systems is considered.
References
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Journal ArticleDOI
Hallmarks of cancer: the next generation.
TL;DR: Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer.
Journal ArticleDOI
Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008.
TL;DR: The results for 20 world regions are presented, summarizing the global patterns for the eight most common cancers, and striking differences in the patterns of cancer from region to region are observed.
Journal ArticleDOI
Lessons from Hereditary Colorectal Cancer
TL;DR: The authors are grateful to the members of their laboratories for their contributions to the reviewed studies and to F. Giardiello and S. Hamilton for photographs of colorectal lesions.
Journal ArticleDOI
Identification of stem cells in small intestine and colon by marker gene Lgr5
Nick Barker,Johan H. van Es,Jeroen Kuipers,Pekka Kujala,Maaike van den Born,Miranda Cozijnsen,Andrea Haegebarth,Jeroen Korving,Harry Begthel,Peter J. Peters,Hans Clevers +10 more
TL;DR: The expression pattern of Lgr5 suggests that it marks stem cells in multiple adult tissues and cancers, suggesting that it represents the stem cell of the small intestine and colon.