Journal ArticleDOI
Tracing the cellular origin of cancer
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TLDR
This review explores how mouse genetic lineage-tracing experiments that allow the expression of oncogenes and/or the deletion of tumour suppressor genes in defined cell lineages have been instrumental in defining the cellular origin of different solid tumours in mouse models for various human cancers.Abstract:
Although many genes that lead to different types of cancer when mutated have been identified, the cells that initiate tumour formation following accumulation of these mutations have, until recently, remained elusive. This review explores how mouse genetic lineage-tracing experiments that allow the expression of oncogenes and/or the deletion of tumour suppressor genes in defined cell lineages have been instrumental in defining the cellular origin of different solid tumours in mouse models for various human cancers.read more
Citations
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Demonstration of CRISPR/Cas9/sgRNA-mediated targeted gene modification in Arabidopsis, tobacco, sorghum and rice
TL;DR: Adaptations of the type II CRISPR/Cas system leading to successful expression of the Cas9/sgRNA system in model plant and crop species bodes well for its near-term use as a facile and powerful means of plant genetic engineering for scientific and agricultural applications.
Journal ArticleDOI
Unravelling cancer stem cell potential
Benjamin Beck,Cédric Blanpain +1 more
TL;DR: In this Opinion article, the different parallels that can be drawn between adult SCs and CSCs in solid tumours are discussed.
Journal ArticleDOI
Dedifferentiation of committed epithelial cells into stem cells in vivo
Purushothama Rao Tata,Hongmei Mou,Ana Pardo-Saganta,Rui Zhao,Mythili Prabhu,Brandon M. Law,Vladimir Vinarsky,Josalyn L. Cho,Sylvie Breton,Amar Sahay,Benjamin D. Medoff,Jayaraj Rajagopal +11 more
TL;DR: Evidence is presented that differentiated airway epithelial cells can revert into stable and functional stem cells in vivo, and this capacity of committed cells to dedifferentiate into stem cells may have a more general role in the regeneration of many tissues and in multiple disease states, notably cancer.
Journal ArticleDOI
Cancer Stem Cells: Basic Concepts and Therapeutic Implications
Dany Nassar,Cédric Blanpain +1 more
TL;DR: This review discusses how the concept of CSCs has been defined, what assays are currently used to define the functional properties of C SCs, what intrinsic and extrinsic mechanisms regulate CSC functions, how plastic CSC's are, and the importance of epithelial-to-mesenchymal transition in conferring CSC properties.
Journal ArticleDOI
Defining the Hallmarks of Metastasis
Danny R. Welch,Douglas R. Hurst +1 more
TL;DR: By defining these first principles of metastasis, this review identifies four distinguishing features that are required: motility and invasion, ability to modulate the secondary site or local microenvironments, plasticity, and ability to colonize secondary tissues.
References
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Journal ArticleDOI
K-ras activation generates an inflammatory response in lung tumors
Hongbin Ji,A. M. Houghton,Thomas J. Mariani,Samanthi A. Perera,C. B. Kim,Robert F. Padera,Giovanni Tonon,Kate McNamara,Luiz A. Marconcini,Aram F. Hezel,N. El-Bardeesy,Roderick T. Bronson,David J. Sugarbaker,Richard S. Maser,Steven D. Shapiro,Kwok-Kin Wong +15 more
TL;DR: Surprisingly, K-ras activation in the bronchiolar epithelium is associated with a robust inflammatory response characterized by an abundant infiltration of alveolar macrophages and neutrophils and provides an excellent means to further study the complex interactions between inflammatory cells, chemokines and tumor progression.
Journal ArticleDOI
Epidermal progenitors give rise to Merkel cells during embryonic development and adult homeostasis
Alexandra Van Keymeulen,Guilhem Mascré,Khalil Kass Youseff,Itamar Harel,Cindy Michaux,Natalie De Geest,Caroline Szpalski,Younes Achouri,Wilhelm Bloch,Bassem A. Hassan,Cédric Blanpain +10 more
TL;DR: Lineage-tracing experiments show that the origin of specialized mechanosensory Merkel cells in the skin is epidermal progenitors, not the neural crest.
Journal ArticleDOI
Bcl-2 and accelerated DNA repair mediates resistance of hair follicle bulge stem cells to DNA-damage-induced cell death
Panagiota A. Sotiropoulou,Aurélie Candi,Guilhem Mascré,Sarah De Clercq,Khalil Kass Youssef,Gaëlle Lapouge,Ellen Dahl,Claudio Semeraro,Geertrui Denecker,Jean-Christophe Marine,Cédric Blanpain +10 more
TL;DR: It is shown that multipotent hair-follicle-bulgeSCs have two important mechanisms for increasing their resistance to DNA-damage-induced cell death: higher expression of the anti-apoptotic gene Bcl-2 and transient stabilization of p53 after DNA damage in bulge SCs.
Journal ArticleDOI
The ordered architecture of murine ear epidermis is maintained by progenitor cells with random fate.
TL;DR: It is concluded that the ordered architecture of the epidermis is maintained by a stochastic progenitor cell population, providing a simple and robust mechanism of homeostasis.
Journal ArticleDOI
Molecular genetics of lung cancer.
Michael J. Birrer,John D. Minna +1 more
TL;DR: The new knowledge of the human genome coupled with global methods of detecting genetic abnormalities and profiling gene expression in tumor cells may enable us to understand the signaling pathways of lung cancer cells and are molecular targets for new cancer therapeutics such as receptor tyrosine kinase inhibitors.