Journal ArticleDOI
Tracing the cellular origin of cancer
Reads0
Chats0
TLDR
This review explores how mouse genetic lineage-tracing experiments that allow the expression of oncogenes and/or the deletion of tumour suppressor genes in defined cell lineages have been instrumental in defining the cellular origin of different solid tumours in mouse models for various human cancers.Abstract:
Although many genes that lead to different types of cancer when mutated have been identified, the cells that initiate tumour formation following accumulation of these mutations have, until recently, remained elusive. This review explores how mouse genetic lineage-tracing experiments that allow the expression of oncogenes and/or the deletion of tumour suppressor genes in defined cell lineages have been instrumental in defining the cellular origin of different solid tumours in mouse models for various human cancers.read more
Citations
More filters
Journal ArticleDOI
Demonstration of CRISPR/Cas9/sgRNA-mediated targeted gene modification in Arabidopsis, tobacco, sorghum and rice
TL;DR: Adaptations of the type II CRISPR/Cas system leading to successful expression of the Cas9/sgRNA system in model plant and crop species bodes well for its near-term use as a facile and powerful means of plant genetic engineering for scientific and agricultural applications.
Journal ArticleDOI
Unravelling cancer stem cell potential
Benjamin Beck,Cédric Blanpain +1 more
TL;DR: In this Opinion article, the different parallels that can be drawn between adult SCs and CSCs in solid tumours are discussed.
Journal ArticleDOI
Dedifferentiation of committed epithelial cells into stem cells in vivo
Purushothama Rao Tata,Hongmei Mou,Ana Pardo-Saganta,Rui Zhao,Mythili Prabhu,Brandon M. Law,Vladimir Vinarsky,Josalyn L. Cho,Sylvie Breton,Amar Sahay,Benjamin D. Medoff,Jayaraj Rajagopal +11 more
TL;DR: Evidence is presented that differentiated airway epithelial cells can revert into stable and functional stem cells in vivo, and this capacity of committed cells to dedifferentiate into stem cells may have a more general role in the regeneration of many tissues and in multiple disease states, notably cancer.
Journal ArticleDOI
Cancer Stem Cells: Basic Concepts and Therapeutic Implications
Dany Nassar,Cédric Blanpain +1 more
TL;DR: This review discusses how the concept of CSCs has been defined, what assays are currently used to define the functional properties of C SCs, what intrinsic and extrinsic mechanisms regulate CSC functions, how plastic CSC's are, and the importance of epithelial-to-mesenchymal transition in conferring CSC properties.
Journal ArticleDOI
Defining the Hallmarks of Metastasis
Danny R. Welch,Douglas R. Hurst +1 more
TL;DR: By defining these first principles of metastasis, this review identifies four distinguishing features that are required: motility and invasion, ability to modulate the secondary site or local microenvironments, plasticity, and ability to colonize secondary tissues.
References
More filters
Journal ArticleDOI
Multistep skin cancer in mice as a model to study the evolution of cancer cells
TL;DR: Analysis of the multistage skin cancer model in mice reveals that a diverse array of signals can selectively impair or enhance clonal expansion of Ras mutant cells into a visible neoplasm, indicating that tumor cells have an inherent reduced capacity to buffer against perturbations.
Journal ArticleDOI
Activated ras Genes Occur in Human Actinic Keratoses, Premalignant Precursors to Squamous Cell Carcinomas
TL;DR: Activated ras genes can play important roles during early stages of squamous cell carcinoma development, and Aberrant repair of UV-induced pyrimidine dimers is a likely cause of this activation.
Journal ArticleDOI
Wounding mobilizes hair follicle stem cells to form tumors
Sunny Y. Wong,Jeremy F. Reiter +1 more
TL;DR: It is found that expression of an activated form of Smo by stem cells of the hair-follicle bulge and secondary hair germ does not induce robust Hh signaling or produce BCCs, demonstrating that BCC-like tumors can originate from follicular stem cells and provide an explanation for the association between wounding and tumorigenesis.
Journal ArticleDOI
Wounding enhances epidermal tumorigenesis by recruiting hair follicle keratinocytes
Maria Kasper,Viljar Jaks,Alexandra Are,Åsa Bergström,Anja Schwäger,Jessica Svärd,Stephan Teglund,Nick Barker,Rune Toftgård +8 more
TL;DR: It is shown that the wound environment accelerates the initiation frequency and growth of BCC-like lesions, due to recruitment of tumor-initiating cells originating from the neighboring HFs, establishing a link between epidermal wounds and skin cancer risk.
Journal ArticleDOI
Adult interfollicular tumour-initiating cells are reprogrammed into an embryonic hair follicle progenitor-like fate during basal cell carcinoma initiation
Khalil Kass Youssef,Gaëlle Lapouge,Karine Bouvrée,Sandrine Rorive,Sylvain Brohée,Ornella Appelstein,Jean-Christophe Larsimont,Vijayakumar Sukumaran,Bram Van de Sande,Doriana Pucci,Sophie Dekoninck,Jean-Valery Berthe,Stein Aerts,Isabelle Salmon,Véronique Del Marmol,Cédric Blanpain +15 more
TL;DR: It is found that tumour-initiating cells are massively reprogrammed into a fate resembling that of embryonic hair follicle progenitors (EHFPs), and Wnt/ β-catenin signalling was very rapidly activated following SmoM2 expression in adult epidermis and coincided with the expression of EHFP markers.