Journal ArticleDOI
Tracing the cellular origin of cancer
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TLDR
This review explores how mouse genetic lineage-tracing experiments that allow the expression of oncogenes and/or the deletion of tumour suppressor genes in defined cell lineages have been instrumental in defining the cellular origin of different solid tumours in mouse models for various human cancers.Abstract:
Although many genes that lead to different types of cancer when mutated have been identified, the cells that initiate tumour formation following accumulation of these mutations have, until recently, remained elusive. This review explores how mouse genetic lineage-tracing experiments that allow the expression of oncogenes and/or the deletion of tumour suppressor genes in defined cell lineages have been instrumental in defining the cellular origin of different solid tumours in mouse models for various human cancers.read more
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Cells of origin of pancreatic neoplasms
TL;DR: Pancreatic ductal adenocarcinoma is a lethal malignant disease associated with poor prognosis, despite recent medical advances and further studies are needed to fully understand the initial processes of pancreatic cancer.
Journal ArticleDOI
ATOH1 Promotes Leptomeningeal Dissemination and Metastasis of Sonic Hedgehog Subgroup Medulloblastomas.
Katie Baker Grausam,Samuel D.R. Dooyema,Laure Bihannic,Hasitha Premathilake,A. Sorana Morrissy,Antoine Forget,Amanda Schaefer,Justin H. Gundelach,Slobodan Macura,Diane M. Maher,Xin Wang,Alex H. Heglin,Xijin Ge,Erliang Zeng,Stéphanie Puget,Indra Chandrasekar,Kameswaran Surendran,Richard J. Bram,Ulrich Schüller,Michael D. Talyor,Olivier Ayrault,Olivier Ayrault,Haotian Zhao +22 more
TL;DR: A dynamic ATOH1-driven molecular cascade underlying medulloblastoma metastasis that offers possible therapeutic opportunities is revealed, indicating a shift in transcriptomic and epigenomic landscapes during metastasis.
Journal ArticleDOI
New insights into the functions of Cox-2 in skin and esophageal malignancies
TL;DR: Experimental evidence from genetically engineered mouse models demonstrating that expression of an enzyme called cyclooxygenase-2 (Cox-2) is critical to the transformation of stem and progenitor cells in the skin and esophagus into cancer cells is discussed.
Journal ArticleDOI
JMJD1C-mediated metabolic dysregulation contributes to HOXA9-dependent leukemogenesis
Jennifer R Lynch,Basit Salik,Patrick Connerty,Binje Vick,Halina H.L. Leung,Aster E. Pijning,Irmela Jeremias,Karsten Spiekermann,Karsten Spiekermann,Toby Trahair,Tao Liu,Michelle Haber,Murray D. Norris,Andrew J. Woo,Philip J. Hogg,Jianlong Wang,Jenny Y. Wang +16 more
TL;DR: The data establish a direct link between drug responses and endogenous expression of JMJD1C and HOXA9 in human AML cell line- and patient-derived xenografts and demonstrate a previously unappreciated role for JM JD1C in counteracting adverse metabolic changes and retaining the metabolic integrity during tumorigenesis, which can be exploited therapeutically.
Journal ArticleDOI
The CD26/DPP4-inhibitor vildagliptin suppresses lung cancer growth via macrophage-mediated NK cell activity.
Jae-Hwi Jang,F. Janker,Ingrid De Meester,Stephan Arni,Nathalie Borgeaud,Yoshito Yamada,Ignacio Gil Bazo,Walter Weder,Wolfgang Jungraithmayr +8 more
TL;DR: The data provide evidence that the CD26/DPP4-inhibitor vildagliptin reduces lung cancer growth and could demonstrate that this effect is exerted by surfactant-activated macrophages and NK cells that act against the tumor via TRAIL-mediated cytotoxicity.
References
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Lessons from Hereditary Colorectal Cancer
TL;DR: The authors are grateful to the members of their laboratories for their contributions to the reviewed studies and to F. Giardiello and S. Hamilton for photographs of colorectal lesions.
Journal ArticleDOI
Identification of stem cells in small intestine and colon by marker gene Lgr5
Nick Barker,Johan H. van Es,Jeroen Kuipers,Pekka Kujala,Maaike van den Born,Miranda Cozijnsen,Andrea Haegebarth,Jeroen Korving,Harry Begthel,Peter J. Peters,Hans Clevers +10 more
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