Journal ArticleDOI
Tracing the cellular origin of cancer
Reads0
Chats0
TLDR
This review explores how mouse genetic lineage-tracing experiments that allow the expression of oncogenes and/or the deletion of tumour suppressor genes in defined cell lineages have been instrumental in defining the cellular origin of different solid tumours in mouse models for various human cancers.Abstract:
Although many genes that lead to different types of cancer when mutated have been identified, the cells that initiate tumour formation following accumulation of these mutations have, until recently, remained elusive. This review explores how mouse genetic lineage-tracing experiments that allow the expression of oncogenes and/or the deletion of tumour suppressor genes in defined cell lineages have been instrumental in defining the cellular origin of different solid tumours in mouse models for various human cancers.read more
Citations
More filters
Journal ArticleDOI
Demonstration of CRISPR/Cas9/sgRNA-mediated targeted gene modification in Arabidopsis, tobacco, sorghum and rice
TL;DR: Adaptations of the type II CRISPR/Cas system leading to successful expression of the Cas9/sgRNA system in model plant and crop species bodes well for its near-term use as a facile and powerful means of plant genetic engineering for scientific and agricultural applications.
Journal ArticleDOI
Unravelling cancer stem cell potential
Benjamin Beck,Cédric Blanpain +1 more
TL;DR: In this Opinion article, the different parallels that can be drawn between adult SCs and CSCs in solid tumours are discussed.
Journal ArticleDOI
Dedifferentiation of committed epithelial cells into stem cells in vivo
Purushothama Rao Tata,Hongmei Mou,Ana Pardo-Saganta,Rui Zhao,Mythili Prabhu,Brandon M. Law,Vladimir Vinarsky,Josalyn L. Cho,Sylvie Breton,Amar Sahay,Benjamin D. Medoff,Jayaraj Rajagopal +11 more
TL;DR: Evidence is presented that differentiated airway epithelial cells can revert into stable and functional stem cells in vivo, and this capacity of committed cells to dedifferentiate into stem cells may have a more general role in the regeneration of many tissues and in multiple disease states, notably cancer.
Journal ArticleDOI
Cancer Stem Cells: Basic Concepts and Therapeutic Implications
Dany Nassar,Cédric Blanpain +1 more
TL;DR: This review discusses how the concept of CSCs has been defined, what assays are currently used to define the functional properties of C SCs, what intrinsic and extrinsic mechanisms regulate CSC functions, how plastic CSC's are, and the importance of epithelial-to-mesenchymal transition in conferring CSC properties.
Journal ArticleDOI
Defining the Hallmarks of Metastasis
Danny R. Welch,Douglas R. Hurst +1 more
TL;DR: By defining these first principles of metastasis, this review identifies four distinguishing features that are required: motility and invasion, ability to modulate the secondary site or local microenvironments, plasticity, and ability to colonize secondary tissues.
References
More filters
Journal ArticleDOI
Cutaneous Squamous-Cell Carcinoma
Murad Alam,Désirée Ratner +1 more
TL;DR: Nonmelanoma skin cancer is the most common cancer in the United States, with over 1.3 million cases expected to occur in the year 2001 and cutaneous squamous-cell carcinomas are associated with a substantial risk of metastasis.
Journal ArticleDOI
Epidermal homeostasis: a balancing act of stem cells in the skin.
Cédric Blanpain,Elaine Fuchs +1 more
TL;DR: Interestingly, the basic mechanisms and signalling pathways that orchestrate epithelial morphogenesis in the skin are reused during adult life to regulate skin homeostasis.
Journal ArticleDOI
Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer
Shunyou Wang,Jing Gao,Qun-Ying Lei,Nora Rozengurt,Colin Pritchard,Jing Jiao,George Thomas,Gang Li,Pradip Roy-Burman,Peter S. Nelson,Xin Liu,Hong Wu +11 more
TL;DR: Global assessment of molecular changes caused by homozygous Pten deletion identified key genes known to be relevant to human prostate cancer, including those "signature" genes associated with human cancer metastasis.
Journal ArticleDOI
Bmi1 is expressed in vivo in intestinal stem cells
TL;DR: Unexpectedly, the distribution of Bmi1-expressing stem cells along the length of the small intestine suggested that mammals use more than one molecularly distinguishable adult stem cell subpopulation to maintain organ homeostasis.
Journal ArticleDOI
Lineage Tracing Reveals Lgr5+ Stem Cell Activity in Mouse Intestinal Adenomas
Arnout G Schepers,Hugo J. Snippert,Daniel E. Stange,Maaike van den Born,Johan H. van Es,Marc van de Wetering,Hans Clevers +6 more
TL;DR: Studying mouse models, direct, functional evidence is provided for the presence of stem cell activity within primary intestinal adenomas, a precursor to intestinal cancer.