Journal ArticleDOI
Tracing the cellular origin of cancer
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TLDR
This review explores how mouse genetic lineage-tracing experiments that allow the expression of oncogenes and/or the deletion of tumour suppressor genes in defined cell lineages have been instrumental in defining the cellular origin of different solid tumours in mouse models for various human cancers.Abstract:
Although many genes that lead to different types of cancer when mutated have been identified, the cells that initiate tumour formation following accumulation of these mutations have, until recently, remained elusive. This review explores how mouse genetic lineage-tracing experiments that allow the expression of oncogenes and/or the deletion of tumour suppressor genes in defined cell lineages have been instrumental in defining the cellular origin of different solid tumours in mouse models for various human cancers.read more
Citations
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Demonstration of CRISPR/Cas9/sgRNA-mediated targeted gene modification in Arabidopsis, tobacco, sorghum and rice
TL;DR: Adaptations of the type II CRISPR/Cas system leading to successful expression of the Cas9/sgRNA system in model plant and crop species bodes well for its near-term use as a facile and powerful means of plant genetic engineering for scientific and agricultural applications.
Journal ArticleDOI
Unravelling cancer stem cell potential
Benjamin Beck,Cédric Blanpain +1 more
TL;DR: In this Opinion article, the different parallels that can be drawn between adult SCs and CSCs in solid tumours are discussed.
Journal ArticleDOI
Dedifferentiation of committed epithelial cells into stem cells in vivo
Purushothama Rao Tata,Hongmei Mou,Ana Pardo-Saganta,Rui Zhao,Mythili Prabhu,Brandon M. Law,Vladimir Vinarsky,Josalyn L. Cho,Sylvie Breton,Amar Sahay,Benjamin D. Medoff,Jayaraj Rajagopal +11 more
TL;DR: Evidence is presented that differentiated airway epithelial cells can revert into stable and functional stem cells in vivo, and this capacity of committed cells to dedifferentiate into stem cells may have a more general role in the regeneration of many tissues and in multiple disease states, notably cancer.
Journal ArticleDOI
Cancer Stem Cells: Basic Concepts and Therapeutic Implications
Dany Nassar,Cédric Blanpain +1 more
TL;DR: This review discusses how the concept of CSCs has been defined, what assays are currently used to define the functional properties of C SCs, what intrinsic and extrinsic mechanisms regulate CSC functions, how plastic CSC's are, and the importance of epithelial-to-mesenchymal transition in conferring CSC properties.
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Defining the Hallmarks of Metastasis
Danny R. Welch,Douglas R. Hurst +1 more
TL;DR: By defining these first principles of metastasis, this review identifies four distinguishing features that are required: motility and invasion, ability to modulate the secondary site or local microenvironments, plasticity, and ability to colonize secondary tissues.
References
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Journal ArticleDOI
Pathology of lung cancer.
TL;DR: Current concepts in pathologic classification of lung cancer based on 1999 World Health Organization (WHO) and IASLC classification including squamous dysplasia/carcinoma in situ, atypical adenomatous hyperplasia and diffuse idiopathic pulmonary neuroendocrine cellhyperplasia are reviewed.
Journal ArticleDOI
The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent ‘+4’ cell markers
Javier Muñoz,Daniel E. Stange,Arnout G Schepers,Marc van de Wetering,Bon-Kyoung Koo,Shalev Itzkovitz,Richard Volckmann,Kevin S. Kung,Jan Koster,Sorina Radulescu,Kevin Myant,Rogier Versteeg,Owen J. Sansom,Johan H. van Es,Nick Barker,Alexander van Oudenaarden,Alexander van Oudenaarden,Shabaz Mohammed,Albert J. R. Heck,Hans Clevers +19 more
TL;DR: Using this resource, it is found—and confirm by independent approaches—that the proposed quiescent/‘+4’ stem cell markers Bmi1, Tert, Hopx and Lrig1 are robustly expressed in CBC cells.
Journal ArticleDOI
Interconversion Between Intestinal Stem Cell Populations in Distinct Niches
TL;DR: It is demonstrated that Hopx, an atypical homeobox protein, is a specific marker of +4 cells, which demonstrates a bidirectional lineage relationship between active and quiescent stem cells in their niches.
Journal ArticleDOI
Exploring the Genomes of Cancer Cells: Progress and Promise
TL;DR: An overview of what exhaustive sequencing of cancer genomes across a wide range of human tumors has revealed about the origin and behavioral features of cancer cells and how this genomic information is being exploited to improve diagnosis and therapy of the disease.
Journal ArticleDOI
Pten dose dictates cancer progression in the prostate.
Lloyd C. Trotman,Masaru Niki,Zohar A. Dotan,Jason A. Koutcher,Antonio Di Cristofano,Andrew Xiao,Alan S Khoo,Pradip Roy-Burman,Norman M. Greenberg,Terry Van Dyke,Carlos Cordon-Cardo,Pier Paolo Pandolfi +11 more
TL;DR: The results provide conclusive genetic support for the notion that PTEN is haploinsufficient in tumor suppression and that its dose is a key determinant in cancer progression.