Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis
Jing Yang,Sendurai A. Mani,Joana Liu Donaher,Sridhar Ramaswamy,Sridhar Ramaswamy,Raphael Itzykson,Christophe Côme,Pierre Savagner,Inna Gitelman,Andrea L. Richardson,Robert A. Weinberg +10 more
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TLDR
A mechanistic link between Twist, EMT, and tumor metastasis is established, suggesting that Twist contributes to metastasis by promoting an epithelial-mesenchymal transition (EMT).About:
This article is published in Cell.The article was published on 2004-06-25 and is currently open access. It has received 3670 citations till now. The article focuses on the topics: Twist transcription factor & Metastasis.read more
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NF-κB and epithelial to mesenchymal transition of cancer†
Chengyin Min,Sean Eddy,Sean Eddy,David H. Sherr,David H. Sherr,Gail E. Sonenshein,Gail E. Sonenshein +6 more
TL;DR: This review will first describe studies elucidating the functions of NF‐κB in transcription of master regulator genes that repress an epithelial phenotype, and discuss the roles ofNF‐κBs in control of mesenchymal genes critical for promoting and maintaining an invasive phenotype.
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The epithelial–mesenchymal transition (EMT) phenomenon
TL;DR: Typically in the cancer field, EMT concept appears to be fully relevant in some situations, but the concept has to be adjusted in other situations to reflect tumor cell renewal and plasticity during carcinoma progression and metastasis.
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The BMP Inhibitor Coco Reactivates Breast Cancer Cells at Lung Metastatic sites
Hua Gao,Goutam Chakraborty,Ai Ping Lee-Lim,Qianxing Mo,Markus Decker,Alin Vonica,Ronglai Shen,Edi Brogi,Ali H. Brivanlou,Filippo G. Giancotti +9 more
TL;DR: The findings reveal that metastasis-initiating cells need to overcome organ-specific antimetastatic signals in order to undergo reactivation, and that these latter organs contain niches devoid of bioactive BMP.
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Drug Resistance Driven by Cancer Stem Cells and Their Niche.
TL;DR: The recent advances in the study of CSCs, the niche and especially their collective contribution to resistance are reviewed, since increasingly studies suggest that this interaction should be considered as a target for therapeutic strategies.
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Progression and metastasis of lung cancer.
TL;DR: This review, which dissects the process in several isolated steps such as angiogenesis, hypoxia, circulation, and establishment of a metastatic focus, finds that several of these processes overlap and occur even simultaneously, but such a presentation would be unreadable.
References
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Gene expression profiling predicts clinical outcome of breast cancer
Laura J. van't Veer,Hongyue Dai,Marc J. van de Vijver,Yudong D. He,Augustinus A. M. Hart,Mao Mao,Hans Peterse,Karin van der Kooy,Matthew J. Marton,Anke T. Witteveen,George J. Schreiber,Ron M. Kerkhoven,Christopher J. Roberts,Peter S. Linsley,René Bernards,Stephen H. Friend +15 more
TL;DR: DNA microarray analysis on primary breast tumours of 117 young patients is used and supervised classification is applied to identify a gene expression signature strongly predictive of a short interval to distant metastases (‘poor prognosis’ signature) in patients without tumour cells in local lymph nodes at diagnosis, providing a strategy to select patients who would benefit from adjuvant therapy.
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Epithelial–mesenchymal transitions in tumour progression
TL;DR: Epithelial–mesenchymal transition provides a new basis for understanding the progression of carcinoma towards dedifferentiated and more malignant states.
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New functions for the matrix metalloproteinases in cancer progression
Mikala Egeblad,Zena Werb +1 more
TL;DR: It is shown that the MMPs have functions other than promotion of invasion, have substrates other than components of the extracellular matrix, and that they function before invasion in the development of cancer.
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Involvement of chemokine receptors in breast cancer metastasis.
Anja Müller,Bernhard Homey,Hortensia Soto,Nianfeng Ge,Daniel Catron,Matthew E. Buchanan,Terri McClanahan,Erin Murphy,Wei Yuan,Stephan N. Wagner,Jose Luis Barrera,Alejandro Mohar,Emma Verastegui,Albert Zlotnik +13 more
TL;DR: It is reported that the chemokine receptors CXCR4 and CCR7 are highly expressed in human breast cancer cells, malignant breast tumours and metastases and their respective ligands CXCL12/SDF-1α and CCL21/6Ckine exhibit peak levels of expression in organs representing the first destinations of breast cancer metastasis.
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The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited
TL;DR: It is now known that the potential of a tumour cell to metastasize depends on its interactions with the homeostatic factors that promote tumour-cell growth, survival, angiogenesis, invasion and metastasis.