Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis
Jing Yang,Sendurai A. Mani,Joana Liu Donaher,Sridhar Ramaswamy,Sridhar Ramaswamy,Raphael Itzykson,Christophe Côme,Pierre Savagner,Inna Gitelman,Andrea L. Richardson,Robert A. Weinberg +10 more
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TLDR
A mechanistic link between Twist, EMT, and tumor metastasis is established, suggesting that Twist contributes to metastasis by promoting an epithelial-mesenchymal transition (EMT).About:
This article is published in Cell.The article was published on 2004-06-25 and is currently open access. It has received 3670 citations till now. The article focuses on the topics: Twist transcription factor & Metastasis.read more
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The transcription factor grainyhead-like 2 regulates the molecular composition of the epithelial apical junctional complex
Max Werth,Katharina Walentin,Katharina Walentin,Annekatrin Aue,Annekatrin Aue,Jörg Schönheit,Anne Wuebken,Naomi Pode-Shakked,Larissa Vilianovitch,Bettina Erdmann,Benjamin Dekel,Michael Bader,Jonathan Barasch,Frank Rosenbauer,Friedrich C. Luft,Friedrich C. Luft,Kai M. Schmidt-Ott,Kai M. Schmidt-Ott +17 more
TL;DR: Evidence is provided that Grhl2 acts as a target gene-associated transcriptional activator of apical junctional complex components and, thereby, crucially participates in epithelial differentiation.
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Twist2 contributes to breast cancer progression by promoting an epithelial-mesenchymal transition and cancer stem-like cell self-renewal.
Xiaoguang Fang,Yao Cai,Jia Liu,Zhong Lin Wang,Qiao Wu,Zhongying Zhang,Chaoyong James Yang,Li Yuan,Gaoliang Ouyang +8 more
TL;DR: The overexpression of Twist2 may contribute to breast cancer progression by activating the EMT programme and enhancing the self-renewal of cancer stem-like cells.
Journal ArticleDOI
Twist1-induced dissemination preserves epithelial identity and requires E-cadherin
Eliah R. Shamir,Elisa Pappalardo,Danielle M. Jorgens,Kester Coutinho,Wen-Ting K Tsai,Khaled Aziz,Manfred Auer,Phuoc T. Tran,Joel S. Bader,Andrew J. Ewald +9 more
TL;DR: Expression of the transcription factor Twist1 induces dissemination of normal mammary epithelial cells without changing the RNA levels of epithelial-specific genes such as E-cadherin.
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Non-small cell lung cancer cells survived ionizing radiation treatment display cancer stem cell and epithelial-mesenchymal transition phenotypes
Roberto Gomez-Casal,Chitralekha Bhattacharya,Nandita Ganesh,Lisa A. Bailey,Per H. Basse,Michael K. Gibson,Michael W. Epperly,Vera Levina +7 more
TL;DR: It is suggested that radiation survived cells have a complex phenotype combining the properties of CSCs and EMT, and might be considered as markers of radiotherapy response in NSCLC.
Journal ArticleDOI
TGF-β drives epithelial-mesenchymal transition through δEF1-mediated downregulation of ESRP
Kana Horiguchi,Kei Sakamoto,Daizo Koinuma,Kentaro Semba,Atsushi Inoue,S Inoue,H Fujii,Akira Yamaguchi,Keiji Miyazawa,Kohei Miyazono,Masao Saitoh,Masao Saitoh +11 more
TL;DR: A microarray-based analysis at single exon level found that TGF-β induces broad alteration of splicing patterns by downregulating epithelial splicing regulatory proteins (ESRPs), and δEF1 family proteins repress the expression of ESRPs to regulate alternative splicing during T GF-β-induced EMT and the progression of breast cancers.
References
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Gene expression profiling predicts clinical outcome of breast cancer
Laura J. van't Veer,Hongyue Dai,Marc J. van de Vijver,Yudong D. He,Augustinus A. M. Hart,Mao Mao,Hans Peterse,Karin van der Kooy,Matthew J. Marton,Anke T. Witteveen,George J. Schreiber,Ron M. Kerkhoven,Christopher J. Roberts,Peter S. Linsley,René Bernards,Stephen H. Friend +15 more
TL;DR: DNA microarray analysis on primary breast tumours of 117 young patients is used and supervised classification is applied to identify a gene expression signature strongly predictive of a short interval to distant metastases (‘poor prognosis’ signature) in patients without tumour cells in local lymph nodes at diagnosis, providing a strategy to select patients who would benefit from adjuvant therapy.
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Epithelial–mesenchymal transitions in tumour progression
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New functions for the matrix metalloproteinases in cancer progression
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TL;DR: It is shown that the MMPs have functions other than promotion of invasion, have substrates other than components of the extracellular matrix, and that they function before invasion in the development of cancer.
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TL;DR: It is reported that the chemokine receptors CXCR4 and CCR7 are highly expressed in human breast cancer cells, malignant breast tumours and metastases and their respective ligands CXCL12/SDF-1α and CCL21/6Ckine exhibit peak levels of expression in organs representing the first destinations of breast cancer metastasis.
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The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited
TL;DR: It is now known that the potential of a tumour cell to metastasize depends on its interactions with the homeostatic factors that promote tumour-cell growth, survival, angiogenesis, invasion and metastasis.