Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis
Jing Yang,Sendurai A. Mani,Joana Liu Donaher,Sridhar Ramaswamy,Sridhar Ramaswamy,Raphael Itzykson,Christophe Côme,Pierre Savagner,Inna Gitelman,Andrea L. Richardson,Robert A. Weinberg +10 more
Reads0
Chats0
TLDR
A mechanistic link between Twist, EMT, and tumor metastasis is established, suggesting that Twist contributes to metastasis by promoting an epithelial-mesenchymal transition (EMT).About:
This article is published in Cell.The article was published on 2004-06-25 and is currently open access. It has received 3670 citations till now. The article focuses on the topics: Twist transcription factor & Metastasis.read more
Citations
More filters
Journal ArticleDOI
EMTome: a resource for pan-cancer analysis of epithelial-mesenchymal transition genes and signatures.
Suhas Vasaikar,Abhijeet Deshmukh,Petra den Hollander,Sridevi Addanki,Nick A. Kuburich,Sriya Kudaravalli,Robiya Joseph,Jeffrey T. Chang,Rama Soundararajan,Sendurai A. Mani +9 more
TL;DR: The generation of a database containing EMT gene signatures derived from cell lines, patient-derived xenografts and patient studies across cancer types and multiomics data and the creation of a web-based portal to provide a comprehensive analysis resource are described.
Journal ArticleDOI
Upregulation of microRNA-155 promotes the migration and invasion of colorectal cancer cells through the regulation of claudin-1 expression
TL;DR: The data suggest that miR-155 plays an important role in promoting CRC cell migration and invasion, at least in part through the regulation of claudin-1 expression and controlling metastasis in CRC.
Journal ArticleDOI
Angiopoietin-like protein 1 suppresses SLUG to inhibit cancer cell motility
Tsang Chih Kuo,Ching-Ting Tan,Yi Wen Chang,Yi Wen Chang,Chih Chen Hong,Wei Jiunn Lee,Min Wei Chen,Yung-Ming Jeng,Jean Chiou,Pei Yu,Pai Sheng Chen,Ming-Yang Wang,Michael Hsiao,Jen Liang Su,Min-Liang Kuo +14 more
TL;DR: It is demonstrated that ANGPTL1 represses lung cancer cell motility by abrogating the expression of the EMT mediator SLUG.
Journal ArticleDOI
MiR-506 inhibits multiple targets in the epithelial-to-mesenchymal transition network and is associated with good prognosis in epithelial ovarian cancer.
Yan Sun,Yan Sun,Limei Hu,Hong Zheng,Marina Bagnoli,Yuhong Guo,Rajesha Rupaimoole,Cristian Rodriguez-Aguayo,Gabriel Lopez-Berestein,Ping Ji,Kexin Chen,Anil K. Sood,Delia Mezzanzanica,Jinsong Liu,Baocun Sun,Wei Zhang +15 more
TL;DR: Evidence that miR‐506 simultaneously suppresses vimentin and N‐cad in the suppression of EMT and metastasis is provided and this study represents a new class of miRNA that regulates both E‐ cad and vimentsin/N-cad.
Journal ArticleDOI
Brusatol suppresses STAT3-driven metastasis by downregulating epithelial-mesenchymal transition in hepatocellular carcinoma.
Jong Hyun Lee,Chakrabhavi Dhananjaya Mohan,Amudha Deivasigamani,Young Yun Jung,Shobith Rangappa,Salundi Basappa,Arunachalam Chinnathambi,Tahani Awad Alahmadi,Sulaiman Ali Alharbi,Manoj Garg,Zhi-Xiu Lin,Kanchugarakoppal S. Rangappa,Gautam Sethi,Kam M. Hui,Kwang Seok Ahn +14 more
TL;DR: In this article, the antimetastatic and antitumor efficacy of brusatol (BT) was investigated in a hepatocellular carcinoma (HCC) model.
References
More filters
Journal ArticleDOI
Gene expression profiling predicts clinical outcome of breast cancer
Laura J. van't Veer,Hongyue Dai,Marc J. van de Vijver,Yudong D. He,Augustinus A. M. Hart,Mao Mao,Hans Peterse,Karin van der Kooy,Matthew J. Marton,Anke T. Witteveen,George J. Schreiber,Ron M. Kerkhoven,Christopher J. Roberts,Peter S. Linsley,René Bernards,Stephen H. Friend +15 more
TL;DR: DNA microarray analysis on primary breast tumours of 117 young patients is used and supervised classification is applied to identify a gene expression signature strongly predictive of a short interval to distant metastases (‘poor prognosis’ signature) in patients without tumour cells in local lymph nodes at diagnosis, providing a strategy to select patients who would benefit from adjuvant therapy.
Journal ArticleDOI
Epithelial–mesenchymal transitions in tumour progression
TL;DR: Epithelial–mesenchymal transition provides a new basis for understanding the progression of carcinoma towards dedifferentiated and more malignant states.
Journal ArticleDOI
New functions for the matrix metalloproteinases in cancer progression
Mikala Egeblad,Zena Werb +1 more
TL;DR: It is shown that the MMPs have functions other than promotion of invasion, have substrates other than components of the extracellular matrix, and that they function before invasion in the development of cancer.
Journal ArticleDOI
Involvement of chemokine receptors in breast cancer metastasis.
Anja Müller,Bernhard Homey,Hortensia Soto,Nianfeng Ge,Daniel Catron,Matthew E. Buchanan,Terri McClanahan,Erin Murphy,Wei Yuan,Stephan N. Wagner,Jose Luis Barrera,Alejandro Mohar,Emma Verastegui,Albert Zlotnik +13 more
TL;DR: It is reported that the chemokine receptors CXCR4 and CCR7 are highly expressed in human breast cancer cells, malignant breast tumours and metastases and their respective ligands CXCL12/SDF-1α and CCL21/6Ckine exhibit peak levels of expression in organs representing the first destinations of breast cancer metastasis.
Journal ArticleDOI
The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited
TL;DR: It is now known that the potential of a tumour cell to metastasize depends on its interactions with the homeostatic factors that promote tumour-cell growth, survival, angiogenesis, invasion and metastasis.