Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis
Jing Yang,Sendurai A. Mani,Joana Liu Donaher,Sridhar Ramaswamy,Sridhar Ramaswamy,Raphael Itzykson,Christophe Côme,Pierre Savagner,Inna Gitelman,Andrea L. Richardson,Robert A. Weinberg +10 more
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TLDR
A mechanistic link between Twist, EMT, and tumor metastasis is established, suggesting that Twist contributes to metastasis by promoting an epithelial-mesenchymal transition (EMT).About:
This article is published in Cell.The article was published on 2004-06-25 and is currently open access. It has received 3670 citations till now. The article focuses on the topics: Twist transcription factor & Metastasis.read more
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MicroRNAs: key players in the immune system, differentiation, tumorigenesis and cell death
TL;DR: The role of miRNAs and their targets in contributing to human cancers and their function as regulators of apoptotic pathways and the immune system are summarized.
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Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis
Sara Lovisa,Valerie S. LeBleu,Björn Tampe,Hikaru Sugimoto,Komal Vadnagara,Julienne L. Carstens,Chia Chin Wu,Yohannes Hagos,Birgitta C. Burckhardt,Tsvetelina Pentcheva-Hoang,Hersharan Nischal,James P. Allison,Michael Zeisberg,Raghu Kalluri +13 more
TL;DR: In mouse models of experimentally induced renal fibrosis, conditional deletion of Twist1 or Snai1 in proximal TECs resulted in inhibition of the EMT program and the maintenance of TEC integrity, while also restoring cell proliferation, dedifferentiation-associated repair and regeneration of the kidney parenchyma and attenuating interstitial fibrosis.
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Epithelial–mesenchymal transition in cancer development and its clinical significance
Masaaki Iwatsuki,Koshi Mimori,Takehiko Yokobori,Hideshi Ishi,Toru Beppu,Shoji Nakamori,Hideo Baba,Masaki Mori,Masaki Mori +8 more
TL;DR: In this review, recent findings regarding the involvement of EMT in cancer progression and metastasis are presented and a perspective from clinical and translational viewpoints are provided.
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Matrix stiffness drives epithelial–mesenchymal transition and tumour metastasis through a TWIST1–G3BP2 mechanotransduction pathway
Spencer C. Wei,Laurent Fattet,Jeff H. Tsai,Yurong Guo,Vincent Pai,Hannah E. Majeski,Albert C. Chen,Robert L. Sah,Susan S. Taylor,Adam J. Engler,Jing Yang +10 more
TL;DR: It is reported that TWIST1 is an essential mechanomediator that promotes epithelial–mesenchymal transition (EMT) in response to increasing matrix stiffness that responds to biomechanical signals from the tumour microenvironment to drive EMT, invasion and metastasis.
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Epithelial-mesenchymal transition in cancer metastasis: Mechanisms, markers and strategies to overcome drug resistance in the clinic
TL;DR: This review summarizes the main EMT characteristics and proposes methodologies for better analysis in vitro and cites the recent literature concerning the mechanisms of drug resistance related to EMT in the context of anti-tumour therapies and proposes related new targets for therapy.
References
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Gene expression profiling predicts clinical outcome of breast cancer
Laura J. van't Veer,Hongyue Dai,Marc J. van de Vijver,Yudong D. He,Augustinus A. M. Hart,Mao Mao,Hans Peterse,Karin van der Kooy,Matthew J. Marton,Anke T. Witteveen,George J. Schreiber,Ron M. Kerkhoven,Christopher J. Roberts,Peter S. Linsley,René Bernards,Stephen H. Friend +15 more
TL;DR: DNA microarray analysis on primary breast tumours of 117 young patients is used and supervised classification is applied to identify a gene expression signature strongly predictive of a short interval to distant metastases (‘poor prognosis’ signature) in patients without tumour cells in local lymph nodes at diagnosis, providing a strategy to select patients who would benefit from adjuvant therapy.
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Epithelial–mesenchymal transitions in tumour progression
TL;DR: Epithelial–mesenchymal transition provides a new basis for understanding the progression of carcinoma towards dedifferentiated and more malignant states.
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New functions for the matrix metalloproteinases in cancer progression
Mikala Egeblad,Zena Werb +1 more
TL;DR: It is shown that the MMPs have functions other than promotion of invasion, have substrates other than components of the extracellular matrix, and that they function before invasion in the development of cancer.
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Involvement of chemokine receptors in breast cancer metastasis.
Anja Müller,Bernhard Homey,Hortensia Soto,Nianfeng Ge,Daniel Catron,Matthew E. Buchanan,Terri McClanahan,Erin Murphy,Wei Yuan,Stephan N. Wagner,Jose Luis Barrera,Alejandro Mohar,Emma Verastegui,Albert Zlotnik +13 more
TL;DR: It is reported that the chemokine receptors CXCR4 and CCR7 are highly expressed in human breast cancer cells, malignant breast tumours and metastases and their respective ligands CXCL12/SDF-1α and CCL21/6Ckine exhibit peak levels of expression in organs representing the first destinations of breast cancer metastasis.
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The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited
TL;DR: It is now known that the potential of a tumour cell to metastasize depends on its interactions with the homeostatic factors that promote tumour-cell growth, survival, angiogenesis, invasion and metastasis.