Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis
Jing Yang,Sendurai A. Mani,Joana Liu Donaher,Sridhar Ramaswamy,Sridhar Ramaswamy,Raphael Itzykson,Christophe Côme,Pierre Savagner,Inna Gitelman,Andrea L. Richardson,Robert A. Weinberg +10 more
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TLDR
A mechanistic link between Twist, EMT, and tumor metastasis is established, suggesting that Twist contributes to metastasis by promoting an epithelial-mesenchymal transition (EMT).About:
This article is published in Cell.The article was published on 2004-06-25 and is currently open access. It has received 3670 citations till now. The article focuses on the topics: Twist transcription factor & Metastasis.read more
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Pericyte Depletion Results in Hypoxia-Associated Epithelial-to-Mesenchymal Transition and Metastasis Mediated by Met Signaling Pathway
Vesselina G. Cooke,Valerie S. LeBleu,Doruk Keskin,Zainab Khan,Joyce T. O’Connell,Yingqi Teng,Michael Duncan,Liang Xie,Genta Maeda,Sylvia Vong,Hikaru Sugimoto,Rafael Malagoli Rocha,Aline Santos Damascena,Ricardo R. Brentani,Raghu Kalluri,Raghu Kalluri,Raghu Kalluri +16 more
TL;DR: In this paper, pericyte depletion was associated with increased hypoxia, epithelial-to-mesenchymal transition (EMT), and Met receptor activation in breast cancer patients.
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EMT as the ultimate survival mechanism of cancer cells.
TL;DR: In this paper, a plethora of genes have been identified that are critical for epithelial-mesenchymal transition (EMT) and metastasis formation, which not only induces increased cancer cell motility and invasiveness but also allows cancer cells to avoid apoptosis, anoikis, oncogene addiction, cellular, senescence and general immune defense.
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Activation of NF-kappaB by Akt upregulates Snail expression and induces epithelium mesenchyme transition.
S. Julien,Isabel Puig,Elena Caretti,J. Bonaventure,L. Nelles,F. Van Roy,C. Dargemont,A García de Herreros,Alfonso Bellacosa,Lionel Larue +9 more
TL;DR: It is shown that Snail activation and consequent repression of E-cadherin may depend on AKT-mediated nuclear factor-κB activation, and that NF-κBs induces Snail expression, which is a potential target for antimetastatic therapeutics.
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Cancer biology and NuRD: a multifaceted chromatin remodelling complex
Anne Y. Lai,Paul A. Wade +1 more
TL;DR: Emerging molecular details regarding the recruitment of NuRD to specific loci during development, and the modulation of these events in cancer, are used to illustrate how the inappropriate localization of the complex could contribute to tumour biology.
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Molecular Pathogenesis of Oral Squamous Cell Carcinoma: Implications for Therapy
S. Choi,J.N. Myers +1 more
TL;DR: The rapid progress that has been made in understanding of the molecular alterations contributing to the development of OSCC is leading to improvements in the early diagnosis of tumors and the refinement of biologic treatments individualized to the specific characteristics of a patient’s tumor.
References
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Gene expression profiling predicts clinical outcome of breast cancer
Laura J. van't Veer,Hongyue Dai,Marc J. van de Vijver,Yudong D. He,Augustinus A. M. Hart,Mao Mao,Hans Peterse,Karin van der Kooy,Matthew J. Marton,Anke T. Witteveen,George J. Schreiber,Ron M. Kerkhoven,Christopher J. Roberts,Peter S. Linsley,René Bernards,Stephen H. Friend +15 more
TL;DR: DNA microarray analysis on primary breast tumours of 117 young patients is used and supervised classification is applied to identify a gene expression signature strongly predictive of a short interval to distant metastases (‘poor prognosis’ signature) in patients without tumour cells in local lymph nodes at diagnosis, providing a strategy to select patients who would benefit from adjuvant therapy.
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Epithelial–mesenchymal transitions in tumour progression
TL;DR: Epithelial–mesenchymal transition provides a new basis for understanding the progression of carcinoma towards dedifferentiated and more malignant states.
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New functions for the matrix metalloproteinases in cancer progression
Mikala Egeblad,Zena Werb +1 more
TL;DR: It is shown that the MMPs have functions other than promotion of invasion, have substrates other than components of the extracellular matrix, and that they function before invasion in the development of cancer.
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Involvement of chemokine receptors in breast cancer metastasis.
Anja Müller,Bernhard Homey,Hortensia Soto,Nianfeng Ge,Daniel Catron,Matthew E. Buchanan,Terri McClanahan,Erin Murphy,Wei Yuan,Stephan N. Wagner,Jose Luis Barrera,Alejandro Mohar,Emma Verastegui,Albert Zlotnik +13 more
TL;DR: It is reported that the chemokine receptors CXCR4 and CCR7 are highly expressed in human breast cancer cells, malignant breast tumours and metastases and their respective ligands CXCL12/SDF-1α and CCL21/6Ckine exhibit peak levels of expression in organs representing the first destinations of breast cancer metastasis.
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The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited
TL;DR: It is now known that the potential of a tumour cell to metastasize depends on its interactions with the homeostatic factors that promote tumour-cell growth, survival, angiogenesis, invasion and metastasis.