Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis
Jing Yang,Sendurai A. Mani,Joana Liu Donaher,Sridhar Ramaswamy,Sridhar Ramaswamy,Raphael Itzykson,Christophe Côme,Pierre Savagner,Inna Gitelman,Andrea L. Richardson,Robert A. Weinberg +10 more
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TLDR
A mechanistic link between Twist, EMT, and tumor metastasis is established, suggesting that Twist contributes to metastasis by promoting an epithelial-mesenchymal transition (EMT).About:
This article is published in Cell.The article was published on 2004-06-25 and is currently open access. It has received 3670 citations till now. The article focuses on the topics: Twist transcription factor & Metastasis.read more
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Polyphenolic Nutrients in Cancer Chemoprevention and Metastasis: Role of the Epithelial-to-Mesenchymal (EMT) Pathway.
TL;DR: The role of polyphenols in attenuating EMT-mediated cancer progression and metastasis is analyzed and the most important polyphenol subclasses and members of the poly phenols in reversing metastasis and targeting EMT are discussed.
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Mesenchymal Transition of High-Grade Breast Carcinomas Depends on Extracellular Matrix Control of Myeloid Suppressor Cell Activity
Sabina Sangaletti,Claudio Tripodo,Alessandra Santangelo,Nadia Castioni,Paola Portararo,Alessandro Gulino,Laura Botti,Mariella Parenza,Barbara Cappetti,Rosaria Orlandi,Elda Tagliabue,Claudia Chiodoni,Mario P. Colombo +12 more
TL;DR: It is concluded that that SPARC is regulating the interplay between MDSCs and the ECM to drive the induction of EMT in tumor cells, rendering SPARC-overexpressing tumor cells sensitive to Doxil.
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Prognostic Significance of Twist and N-Cadherin Expression in NSCLC
TL;DR: The overexpression of Twist and N-cadherin could be considered as useful biomarkers for predicting the prognosis of NSCLC.
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Role of the Focal Adhesion Protein Kindlin-1 in Breast Cancer Growth and Lung Metastasis
Soraya Sin,Florian Bonin,Valérie Petit,Didier Meseure,François Lallemand,Ivan Bièche,Akeila Bellahcene,Vincent Castronovo,Olivier De Wever,Christian Gespach,Rosette Lidereau,Keltouma Driouch +11 more
TL;DR: A role for kindlin-1 in breast cancer lung metastasis and lung tumorigenesis is suggested and the understanding of kindLin-1 as a regulator of TGFβ signaling is advanced, offering new avenues for therapeutic intervention against cancer progression.
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Akirin Links Twist-Regulated Transcription with the Brahma Chromatin Remodeling Complex during Embryogenesis
TL;DR: It is proposed that this Akirin-mediated link between transcription factors and the Brahma complex represents a novel paradigm for providing tissue and target specificity for transcription factor interactions with the chromatin remodeling machinery.
References
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Gene expression profiling predicts clinical outcome of breast cancer
Laura J. van't Veer,Hongyue Dai,Marc J. van de Vijver,Yudong D. He,Augustinus A. M. Hart,Mao Mao,Hans Peterse,Karin van der Kooy,Matthew J. Marton,Anke T. Witteveen,George J. Schreiber,Ron M. Kerkhoven,Christopher J. Roberts,Peter S. Linsley,René Bernards,Stephen H. Friend +15 more
TL;DR: DNA microarray analysis on primary breast tumours of 117 young patients is used and supervised classification is applied to identify a gene expression signature strongly predictive of a short interval to distant metastases (‘poor prognosis’ signature) in patients without tumour cells in local lymph nodes at diagnosis, providing a strategy to select patients who would benefit from adjuvant therapy.
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Epithelial–mesenchymal transitions in tumour progression
TL;DR: Epithelial–mesenchymal transition provides a new basis for understanding the progression of carcinoma towards dedifferentiated and more malignant states.
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New functions for the matrix metalloproteinases in cancer progression
Mikala Egeblad,Zena Werb +1 more
TL;DR: It is shown that the MMPs have functions other than promotion of invasion, have substrates other than components of the extracellular matrix, and that they function before invasion in the development of cancer.
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Involvement of chemokine receptors in breast cancer metastasis.
Anja Müller,Bernhard Homey,Hortensia Soto,Nianfeng Ge,Daniel Catron,Matthew E. Buchanan,Terri McClanahan,Erin Murphy,Wei Yuan,Stephan N. Wagner,Jose Luis Barrera,Alejandro Mohar,Emma Verastegui,Albert Zlotnik +13 more
TL;DR: It is reported that the chemokine receptors CXCR4 and CCR7 are highly expressed in human breast cancer cells, malignant breast tumours and metastases and their respective ligands CXCL12/SDF-1α and CCL21/6Ckine exhibit peak levels of expression in organs representing the first destinations of breast cancer metastasis.
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The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited
TL;DR: It is now known that the potential of a tumour cell to metastasize depends on its interactions with the homeostatic factors that promote tumour-cell growth, survival, angiogenesis, invasion and metastasis.