Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis
Jing Yang,Sendurai A. Mani,Joana Liu Donaher,Sridhar Ramaswamy,Sridhar Ramaswamy,Raphael Itzykson,Christophe Côme,Pierre Savagner,Inna Gitelman,Andrea L. Richardson,Robert A. Weinberg +10 more
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TLDR
A mechanistic link between Twist, EMT, and tumor metastasis is established, suggesting that Twist contributes to metastasis by promoting an epithelial-mesenchymal transition (EMT).About:
This article is published in Cell.The article was published on 2004-06-25 and is currently open access. It has received 3670 citations till now. The article focuses on the topics: Twist transcription factor & Metastasis.read more
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Activation of NF-κB by extracellular S100A4: Analysis of signal transduction mechanisms and identification of target genes
TL;DR: It is demonstrated that extracellular S100A4 activates the transcription factor NF‐κB in a subset of human cancer cell lines through induction of phosphorylation and subsequent degradation of the NF‐σκB inhibitor IκBα, and this findings contribute to the understanding of the complex molecular mechanisms responsible for the diverse biological functions of extacellular S 100A4.
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Targeting the Interplay between Epithelial-to-Mesenchymal-Transition and the Immune System for Effective Immunotherapy.
Rama Soundararajan,Jared J. Fradette,Jessica Konen,Stacy L. Moulder,Xiang Zhang,Don L. Gibbons,Navin Varadarajan,Ignacio I. Wistuba,Debasish Tripathy,Chantale Bernatchez,Lauren Averett Byers,Jeffrey T. Chang,Alejandro Contreras,Bora Lim,Edwin R. Parra,Emily Roarty,Jing Wang,Fei Yang,Michelle Craig Barton,Jeffrey M. Rosen,Sendurai A. Mani +20 more
TL;DR: New information and complementary perspectives are discussed to inform combination treatment strategies to expand and improve the anti-tumor responses of currently available clinical immune checkpoint inhibitors.
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Molecular correlates of gefitinib responsiveness in human bladder cancer cells
Marissa Shrader,Maria Simona Pino,Gordon A. Brown,Peter McL. Black,Liana Adam,Menahse Bar-Eli,Colin P.N. Dinney,David J. McConkey +7 more
TL;DR: The results show that bladder cancer cells are markedly heterogeneous with respect to their sensitivity to EGFR antagonists, and surface EGFR levels and epithelial-mesenchymal transition status seem to roughly correlate with responsiveness, they cannot be used by themselves to identify bladder tumors that will be sensitive to EG FR-directed therapy.
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Lycorine: A prospective natural lead for anticancer drug discovery.
TL;DR: The researches outlined in this paper serve as a foundation to explain Lycorine as an important lead compound for new generation anticancer drug design and provide the principle for the development of biological strategies to utilize lycorine in the treatment of cancers.
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Multiple pathways of SIRT6 at the crossroads in the control of longevity, cancer, and cardiovascular diseases
Milena Vitiello,Alberto Zullo,Luigi Servillo,Francesco Mancini,Adriana Borriello,Alfonso Giovane,Fulvio Della Ragione,Nunzia D'Onofrio,Maria Luisa Balestrieri +8 more
TL;DR: Findings suggest that multiple mechanisms, to date not entirely known, underlie the intriguing roles of SIRT6, and describe its recent implications in the atherosclerotic plaque development.
References
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Gene expression profiling predicts clinical outcome of breast cancer
Laura J. van't Veer,Hongyue Dai,Marc J. van de Vijver,Yudong D. He,Augustinus A. M. Hart,Mao Mao,Hans Peterse,Karin van der Kooy,Matthew J. Marton,Anke T. Witteveen,George J. Schreiber,Ron M. Kerkhoven,Christopher J. Roberts,Peter S. Linsley,René Bernards,Stephen H. Friend +15 more
TL;DR: DNA microarray analysis on primary breast tumours of 117 young patients is used and supervised classification is applied to identify a gene expression signature strongly predictive of a short interval to distant metastases (‘poor prognosis’ signature) in patients without tumour cells in local lymph nodes at diagnosis, providing a strategy to select patients who would benefit from adjuvant therapy.
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Epithelial–mesenchymal transitions in tumour progression
TL;DR: Epithelial–mesenchymal transition provides a new basis for understanding the progression of carcinoma towards dedifferentiated and more malignant states.
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New functions for the matrix metalloproteinases in cancer progression
Mikala Egeblad,Zena Werb +1 more
TL;DR: It is shown that the MMPs have functions other than promotion of invasion, have substrates other than components of the extracellular matrix, and that they function before invasion in the development of cancer.
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Involvement of chemokine receptors in breast cancer metastasis.
Anja Müller,Bernhard Homey,Hortensia Soto,Nianfeng Ge,Daniel Catron,Matthew E. Buchanan,Terri McClanahan,Erin Murphy,Wei Yuan,Stephan N. Wagner,Jose Luis Barrera,Alejandro Mohar,Emma Verastegui,Albert Zlotnik +13 more
TL;DR: It is reported that the chemokine receptors CXCR4 and CCR7 are highly expressed in human breast cancer cells, malignant breast tumours and metastases and their respective ligands CXCL12/SDF-1α and CCL21/6Ckine exhibit peak levels of expression in organs representing the first destinations of breast cancer metastasis.
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The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited
TL;DR: It is now known that the potential of a tumour cell to metastasize depends on its interactions with the homeostatic factors that promote tumour-cell growth, survival, angiogenesis, invasion and metastasis.