Universal Vaccines and Vaccine Platforms to Protect against Influenza Viruses in Humans and Agriculture.
Daniela S. Rajao,Daniel R. Perez +1 more
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TLDR
Current vaccines to protect humans and animals against influenza are discussed, highlighting challenges faced to effective and uniform novel vaccination strategies and approaches.Abstract:
Influenza virus infections pose a significant threat to public health due to annual seasonal epidemics and occasional pandemics. Influenza is also associated with significant economic losses in animal production. The most effective way to prevent influenza infections is through vaccination. Current vaccine programs rely heavily on the vaccine's ability to stimulate neutralizing antibody responses to the hemagglutinin (HA) protein. One of the biggest challenges to an effective vaccination program lies on the fact that influenza viruses are ever-changing, leading to antigenic drift that results in escape from earlier immune responses. Efforts toward overcoming these challenges aim at improving the strength and/or breadth of the immune response. Novel vaccine technologies, the so-called universal vaccines, focus on stimulating better cross-protection against many or all influenza strains. However, vaccine platforms or manufacturing technologies being tested to improve vaccine efficacy are heterogeneous between different species and/or either tailored for epidemic or pandemic influenza. Here, we discuss current vaccines to protect humans and animals against influenza, highlighting challenges faced to effective and uniform novel vaccination strategies and approaches.read more
Citations
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Mechanism of Virus Attenuation by Codon Pair Deoptimization
Nicole Groenke,Jakob Trimpert,Sophie Merz,Andelé M. Conradie,Emanuel Wyler,Hongwei Zhang,Orsalia-Georgia Hazapis,Sebastian Rausch,Markus Landthaler,Nikolaus Osterrieder,Dusan Kunec +10 more
TL;DR: It is shown that suboptimal codon pairs cause attenuation, whereas the increase of CpG dinucleotides has no effect, and that codon pair bias can be used to increase mRNA stability and protein production of synthetic genes in many areas of biotechnology.
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Novel Approaches for The Development of Live Attenuated Influenza Vaccines
TL;DR: The discovery and implementation of plasmid-based reverse genetics has been a key advance in the rapid generation of recombinant attenuated influenza viruses that can be used for the development of new and most effective LAIVs, which reveal their possible implementation in combating influenza infections.
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A single dose of a vesicular stomatitis virus-based influenza vaccine confers rapid protection against H5 viruses from different clades
Wakako Furuyama,Pierce Reynolds,Pierce Reynolds,Elaine Haddock,Kimberly Meade-White,Mai Quynh Le,Yoshihiro Kawaoka,Yoshihiro Kawaoka,Heinz Feldmann,Andrea Marzi +9 more
TL;DR: It was found that a single dose of VSV vectors expressing full-length hemagglutinin (HAfl) were sufficient to provide 100% protection, highlighting the potential of the VSV-based HAfl as a pan-H5 influenza virus emergency vaccine.
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Enhanced inhibition of influenza virus infection by peptide-noble-metal nanoparticle conjugates.
TL;DR: It is demonstrated that conjugation of FluPep to gold and silver nanoparticles enhances its antiviral potency; the antimicrobial activity of silver ions may enable the design of even more potent antimicrobial inhibitors, capable of targeting both influenza and bacterial co-infections.
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Comparing influenza vaccine effectiveness between cell-derived and egg-derived vaccines, 2017-2018 influenza season.
TL;DR: The cell-derived and egg-derived vaccines were moderately protective against all influenza types with significant VE estimates for all dependents at 46% (95% confidence interval, 33, 56) and 53% (45, 60), respectively.
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