Virus-Receptor Interactions: The Key to Cellular Invasion.
TLDR
The redundancy in receptor usage suggests that viruses target particular receptors or “common locks” to take advantage of their cellular function and also suggests evolutionary conservation.About:
This article is published in Journal of Molecular Biology.The article was published on 2018-08-17 and is currently open access. It has received 205 citations till now. The article focuses on the topics: Virus receptor & Viral Receptor.read more
Citations
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Journal ArticleDOI
Broad host range of SARS-CoV-2 predicted by comparative and structural analysis of ACE2 in vertebrates.
Joana Damas,Graham M. Hughes,Kathleen C. Keough,Corrie A. Painter,Nicole S. Persky,Marco Corbo,Michael Hiller,Klaus-Peter Koepfli,Andreas R. Pfenning,Huabin Zhao,Huabin Zhao,Diane P. Genereux,Ross Swofford,Katherine S. Pollard,Oliver A. Ryder,Martin T. Nweeia,Martin T. Nweeia,Martin T. Nweeia,Kerstin Lindblad-Toh,Kerstin Lindblad-Toh,Emma C. Teeling,Elinor K. Karlsson,Elinor K. Karlsson,Harris A. Lewin +23 more
TL;DR: A large number of mammals that can potentially be infected by SARS-CoV-2 via their ACE2 proteins are identified to assist the identification of intermediate hosts for Sars-Cov-2 and hence reduce the opportunity for a future outbreak of COVID-19.
Journal ArticleDOI
Saliva: potential diagnostic value and transmission of 2019-nCoV.
TL;DR: Diagnostic value of saliva for 2019-nCoV, possibly direct invasion into oral tissues, and close contact transmission of 2019-NCoV by saliva droplets, expecting to contribute to 2019- nCoV epidemic control are summarized.
Journal ArticleDOI
COVID-19, Renin-Angiotensin System and Endothelial Dysfunction
Razie Amraei,Nader Rahimi +1 more
TL;DR: The molecular basis of Sars-CoV-2 infection, the roles of ACE2, RAS signaling, and a possible link between the pre-existing endothelial dysfunction and SARS-Cov-2 induced endothelial injury in COVID-19 associated mortality are reviewed.
Journal ArticleDOI
COVID-19 and Cardiovascular Disease: From Bench to Bedside.
Mina K. Chung,David A. Zidar,Michael R. Bristow,Scott J. Cameron,Timothy A. Chan,Clifford V. Harding,Deborah H. Kwon,Tamanna Singh,John C. Tilton,Emily J. Tsai,Nathan R. Tucker,John Barnard,Joseph Loscalzo +12 more
TL;DR: A review of the clinical manifestations of cardiovascular involvement, potential direct SARS-CoV-2 and indirect immune response mechanisms impacting the cardiovascular system, and implications for the management of patients after recovery from acute COVID-19 infection is provided in this article.
Journal ArticleDOI
Monocytes and Macrophages as Viral Targets and Reservoirs
TL;DR: The majority of viruses discussed in this review employ monocytes/macrophages as a repository but certain viruses use these cells for productive replication, as shown in the case of the influenza, Chikungunya, human herpes and Zika viruses.
References
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Journal ArticleDOI
Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia
Ali Moh Zaki,Sander van Boheemen,Theo M. Bestebroer,Albert D. M. E. Osterhaus,Ron A. M. Fouchier +4 more
TL;DR: The clinical picture was remarkably similar to that of the severe acute respiratory syndrome (SARS) outbreak in 2003 and reminds us that animal coronaviruses can cause severe disease in humans.
Journal ArticleDOI
Isolation of a Common Receptor for Coxsackie B Viruses and Adenoviruses 2 and 5
Jeffrey M. Bergelson,Jennifer Cunningham,Gustavo Droguett,Evelyn A. Kurt-Jones,Anita Krithivas,Jeong S. Hong,Marshall S. Horwitz,Richard L. Crowell,Robert W. Finberg +8 more
TL;DR: Identification of CAR as a receptor for these two unrelated and structurally distinct viral pathogens is important for understanding viral pathogenesis and has implications for therapeutic gene delivery with adenovirus vectors.
Journal ArticleDOI
Clonal integration of a polyomavirus in human Merkel cell carcinoma.
TL;DR: In six of eight MCV-positive MCCs, viral DNA was integrated within the tumor genome in a clonal pattern, suggesting that MCV infection and integration preceded clonal expansion of the tumor cells, and MCV may be a contributing factor in the pathogenesis of MCC.
Journal ArticleDOI
Receptor Binding and Membrane Fusion in Virus Entry: The Influenza Hemagglutinin
John J. Skehel,Don C. Wiley +1 more
TL;DR: Comparisons to the soluble N-ethyl-maleimide-sensitive factor attachment protein receptor (SNARE) protein complex of vesicle fusion suggests that these molecules are all in the fusion-activated conformation and that the juxtaposition of the membrane anchor and fusion peptide, a recurring feature, is involved in the fused mechanism.
Journal ArticleDOI
DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells
Teunis B.H. Geijtenbeek,Douglas S. Kwon,Ruurd Torensma,S.J. van Vliet,G.C.F. van Duijnhoven,J. Middel,I.L.M.H.A. Cornelissen,H.S.L.M. Nottet,Vineet N. KewalRamani,Dan R. Littman,Carl G. Figdor,Y. van Kooyk +11 more
TL;DR: It is proposed that DC-SIGN efficiently captures HIV-1 in the periphery and facilitates its transport to secondary lymphoid organs rich in T cells, to enhance infection in trans of these target cells.
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