X chromosomal regulation in flies: when less is more
Erinc Hallacli,Asifa Akhtar +1 more
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TLDR
It is becoming increasingly clear that although the X chromosome achieves male specific regulation via the MSL complex members, a number of general factors also impinge on this regulation.Abstract:
In Drosophila, dosage compensation of the single male X chromosome involves upregulation of expression of X linked genes Dosage compensation complex or the male specific lethal (MSL) complex is intimately involved in this regulation The MSL complex members decorate the male X chromosome by binding on hundreds of sites along the X chromosome Recent genome wide analysis has brought new light into X chromosomal regulation It is becoming increasingly clear that although the X chromosome achieves male specific regulation via the MSL complex members, a number of general factors also impinge on this regulation Future studies integrating these aspects promise to shed more light into this epigenetic phenomenonread more
Citations
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How do lncRNAs regulate transcription
TL;DR: Recent progress in elucidating the molecular mechanisms by which lncRNAs modulate gene expression is reviewed, including the act of lnc RNA transcription rather than the lncRNA product that appears to be regulatory.
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Dosage compensation in Drosophila melanogaster : epigenetic fine-tuning of chromosome-wide transcription
Thomas Conrad,Asifa Akhtar +1 more
TL;DR: This Review highlights the known facts and open questions of dosage compensation in D. melanogaster and investigates the intriguing interplay between multiple levels of local and long-range chromatin regulation required for the fine-tuned transcriptional activation of a heterogeneous gene population.
Journal ArticleDOI
The NSL complex regulates housekeeping genes in Drosophila.
Kin Chung Lam,Friederike Mühlpfordt,Juan M. Vaquerizas,Sunil Jayaramaiah Raja,Heribert Holz,Nicholas M. Luscombe,Thomas Manke,Asifa Akhtar +7 more
TL;DR: The findings show that the MOF-containing NSL complex acts as a major regulator of housekeeping genes in flies by modulating initiation of Pol II transcription.
Journal ArticleDOI
Buffering and the evolution of chromosome-wide gene regulation.
Per Stenberg,Jan Larsson +1 more
TL;DR: The origin and function of buffering and compensation using Drosophila as a model is discussed and three known compensatory mechanisms have evolved: a general segmental aneuploidy-buffering system and two chromosome-specific systems.
Journal ArticleDOI
Msl1-Mediated Dimerization of the Dosage Compensation Complex Is Essential for Male X-Chromosome Regulation in Drosophila
Erinc Hallacli,Michael Lipp,Plamen Georgiev,Clare Spielman,Stephen Cusack,Asifa Akhtar,Jan Kadlec +6 more
TL;DR: It is proposed that Msl1-mediated dimerization of the entire MSL complex is required for Msl2 binding, X chromosome recognition, and spreading along the X chromosome.
References
More filters
Journal ArticleDOI
High-resolution profiling of histone methylations in the human genome.
Artem Barski,Suresh Cuddapah,Kairong Cui,Tae-Young Roh,Dustin E. Schones,Zhibin Wang,Gang Wei,Iouri Chepelev,Keji Zhao +8 more
TL;DR: High-resolution maps for the genome-wide distribution of 20 histone lysine and arginine methylations as well as histone variant H2A.Z, RNA polymerase II, and the insulator binding protein CTCF across the human genome using the Solexa 1G sequencing technology are generated.
Journal ArticleDOI
Histone H4-K16 Acetylation Controls Chromatin Structure and Protein Interactions
Michael Shogren-Knaak,Haruhiko Ishii,Jian-Min Sun,Michael J. Pazin,James R. Davie,Craig L. Peterson +5 more
TL;DR: H4-K16Ac inhibits the ability of the adenosine triphosphate–utilizing chromatin assembly and remodeling enzyme ACF to mobilize a mononucleosome, indicating that this single histone modification modulates both higher order chromatin structure and functional interactions between a nonhistone protein and the chromatin fiber.
Journal ArticleDOI
Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions
Lars Guelen,Ludo Pagie,Emilie Brasset,Wouter Meuleman,Wouter Meuleman,Marius B. Faza,Wendy Talhout,Bert H.J. Eussen,Annelies de Klein,Lodewyk F. A. Wessels,Lodewyk F. A. Wessels,Wouter de Laat,Bas van Steensel +12 more
TL;DR: A high-resolution map of the interaction sites of the entire genome with NL components in human fibroblasts is constructed and demonstrates that the human genome is divided into large, discrete domains that are units of chromosome organization within the nucleus.
Journal ArticleDOI
Genome-wide map of nucleosome acetylation and methylation in yeast.
Dmitry K. Pokholok,Christopher T. Harbison,Stuart S. Levine,Megan F. Cole,Nancy M. Hannett,Tong Ihn Lee,George W. Bell,Kimberly Walker,P. Alex Rolfe,Elizabeth Herbolsheimer,Julia Zeitlinger,Fran Lewitter,David K. Gifford,Richard A. Young +13 more
TL;DR: These maps take into account changes in nucleosome occupancy at actively transcribed genes and, in doing so, revise previous assessments of the modifications associated with gene expression, providing the foundation for further understanding the roles of chromatin in gene expression and genome maintenance.
Journal ArticleDOI
Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription.
Michael J. Carrozza,Bing Li,Laurence Florens,Tamaki Suganuma,Selene K. Swanson,Kenneth K. Lee,Wei-Jong Shia,Scott Anderson,John R. Yates,Michael P. Washburn,Jerry L. Workman +10 more
TL;DR: Data indicate that Pol II-associated Set2 methylates H3 providing a transcriptional memory which signals for deacetylation of ORFs by Rpd3S, which erases transcription elongation-associated acetylation to suppress intragenic transcription initiation.