A
Ariella Cohain
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 29
Citations - 7330
Ariella Cohain is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 16, co-authored 26 publications receiving 6019 citations.
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Journal ArticleDOI
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease
Luke Jostins,Stephan Ripke,Rinse K. Weersma,Richard H. Duerr,Dermot P.B. McGovern,Ken Y. Hui,James Lee,L. Philip Schumm,Yashoda Sharma,Carl A. Anderson,Jonah Essers,Mitja Mitrovic,Kaida Ning,Isabelle Cleynen,Emilie Theatre,Sarah L. Spain,Soumya Raychaudhuri,Philippe Goyette,Zhi Wei,Clara Abraham,Jean-Paul Achkar,Tariq Ahmad,Leila Amininejad,Ashwin N. Ananthakrishnan,Vibeke Andersen,Jane M. Andrews,Leonard Baidoo,Tobias Balschun,Peter A. Bampton,Alain Bitton,Gabrielle Boucher,Stephan Brand,Carsten Büning,Ariella Cohain,Sven Cichon,Mauro D'Amato,Dirk De Jong,Kathy L Devaney,Marla Dubinsky,Cathryn Edwards,David Ellinghaus,Lynnette R. Ferguson,Denis Franchimont,Karin Fransen,Richard B. Gearry,Michel Georges,Christian Gieger,Jürgen Glas,Talin Haritunians,Ailsa Hart,Christopher J. Hawkey,Matija Hedl,Xinli Hu,Tom H. Karlsen,Limas Kupčinskas,Subra Kugathasan,Anna Latiano,Debby Laukens,Ian C. Lawrance,Charlie W. Lees,Edouard Louis,Gillian Mahy,John C. Mansfield,Angharad R. Morgan,Craig Mowat,William G. Newman,Orazio Palmieri,Cyriel Y. Ponsioen,Uroš Potočnik,Natalie J. Prescott,Miguel Regueiro,Jerome I. Rotter,Richard K Russell,Jeremy D. Sanderson,Miquel Sans,Jack Satsangi,Stefan Schreiber,Lisa A. Simms,Jurgita Sventoraityte,Stephan R. Targan,Kent D. Taylor,Mark Tremelling,Hein W. Verspaget,Martine De Vos,Cisca Wijmenga,David C. Wilson,Juliane Winkelmann,Ramnik J. Xavier,Sebastian Zeissig,Bin Zhang,Clarence K. Zhang,Hongyu Zhao,Mark S. Silverberg,Vito Annese,Hakon Hakonarson,Steven R. Brant,Graham L. Radford-Smith,Christopher G. Mathew,John D. Rioux,Eric E. Schadt,Mark J. Daly,Andre Franke,Miles Parkes,Severine Vermeire,Jeffrey C. Barrett,Judy H. Cho +105 more
TL;DR: A meta-analysis of Crohn’s disease and ulcerative colitis genome-wide association scans is undertaken, followed by extensive validation of significant findings, with a combined total of more than 75,000 cases and controls.
Journal ArticleDOI
Deciphering the transcriptional network of the dendritic cell lineage
Jennifer Miller,Brian D. Brown,Tal Shay,Emmanuel L. Gautier,Emmanuel L. Gautier,Vladimir Jojic,Vladimir Jojic,Ariella Cohain,Gaurav Pandey,Marylene Leboeuf,Kutlu G. Elpek,Julie Helft,Daigo Hashimoto,Andrew Chow,Andrew Chow,Jeremy Price,Melanie Greter,Melanie Greter,Milena Bogunovic,Angelique Bellemare-Pelletier,Paul S. Frenette,Gwendalyn J. Randolph,Gwendalyn J. Randolph,Shannon J. Turley,Miriam Merad +24 more
TL;DR: A transcriptional program expressed specifically during the steady-state migration of tissue DCs to the draining lymph nodes that may control tolerance to self tissue antigens is identified and predicted regulators of DC functional diversity in tissues are predicted.
Journal ArticleDOI
Assembly and diploid architecture of an individual human genome via single-molecule technologies
Matthew Pendleton,Robert Sebra,Andy Wing Chun Pang,Ajay Ummat,Oscar Franzén,Tobias Rausch,Adrian M. Stütz,William Stedman,Thomas Anantharaman,Alex Hastie,Heng Dai,Markus Hsi-Yang Fritz,Han Cao,Ariella Cohain,Gintaras Deikus,Russell E. Durrett,Scott C. Blanchard,Roger B. Altman,Chen-Shan Chin,Yan Guo,Ellen E. Paxinos,Jan O. Korbel,Robert B. Darnell,W. Richard McCombie,Pui-Yan Kwok,Christopher E. Mason,Eric E. Schadt,Ali Bashir +27 more
TL;DR: This work shows that it is now possible to integrate single-molecule and high-throughput sequence data to generate de novo assembled genomes that approach reference quality.
Journal ArticleDOI
Endothelial to mesenchymal transition is common in atherosclerotic lesions and is associated with plaque instability
Solene M. Evrard,Laura Lecce,Katherine C. Michelis,Aya Nomura-Kitabayashi,Gaurav Pandey,K-Raman Purushothaman,Valentina d'Escamard,Jennifer Li,Lahouaria Hadri,Kenji Fujitani,Pedro R. Moreno,Ludovic Benard,Pauline Rimmele,Ariella Cohain,Brigham H. Mecham,Gwendalyn J. Randolph,Elizabeth G. Nabel,Roger J. Hajjar,Valentin Fuster,Valentin Fuster,Manfred Boehm,Jason C. Kovacic +21 more
TL;DR: It is shown that EndMT contributes to atherosclerotic patho-biology and is associated with complex plaques that may be related to clinical events, and the extent of EndMT correlates with an unstable plaque phenotype, which appears driven by altered collagen-MMP production in EndMT-derived cells.
Journal ArticleDOI
Feasibility of blood testing combined with PET-CT to screen for cancer and guide intervention
Anne Marie Lennon,Adam H. Buchanan,Isaac Kinde,Andrew Warren,Ashley Honushefsky,Ariella Cohain,David H. Ledbetter,Fred Sanfilippo,Kathleen Sheridan,Dillenia Rosica,Christian S. Adonizio,Hee Jung Hwang,Kamel Lahouel,Joshua D. Cohen,Christopher Douville,Aalpen A. Patel,Leonardo N. Hagmann,David D. K. Rolston,Nirav Malani,Shibin Zhou,Chetan Bettegowda,David L. Diehl,Bobbi Urban,Christopher D. Still,Lisa Kann,Julie I. Woods,Zachary M. Salvati,Joseph Vadakara,Rosemary Leeming,Prianka Bhattacharya,Carroll Walter,Alex Parker,Christoph Lengauer,Alison P. Klein,Alison P. Klein,Cristian Tomasetti,Cristian Tomasetti,Elliot K. Fishman,Ralph H. Hruban,Kenneth W. Kinzler,Bert Vogelstein,Nickolas Papadopoulos +41 more
TL;DR: A large feasibility study shows that a cancer blood test and PET-CT imaging can detect some cancers at an early stage, and could be combined with conventional screening, leading to detection of more than half of the total incident cancers observed during the study period.