Ariella Cohain

TL;DR: A meta-analysis of Crohn’s disease and ulcerative colitis genome-wide association scans is undertaken, followed by extensive validation of significant findings, with a combined total of more than 75,000 cases and controls.

TL;DR: A transcriptional program expressed specifically during the steady-state migration of tissue DCs to the draining lymph nodes that may control tolerance to self tissue antigens is identified and predicted regulators of DC functional diversity in tissues are predicted.

TL;DR: This work shows that it is now possible to integrate single-molecule and high-throughput sequence data to generate de novo assembled genomes that approach reference quality.

TL;DR: It is shown that EndMT contributes to atherosclerotic patho-biology and is associated with complex plaques that may be related to clinical events, and the extent of EndMT correlates with an unstable plaque phenotype, which appears driven by altered collagen-MMP production in EndMT-derived cells.

TL;DR: A large feasibility study shows that a cancer blood test and PET-CT imaging can detect some cancers at an early stage, and could be combined with conventional screening, leading to detection of more than half of the total incident cancers observed during the study period.