D
David Baltimore
Researcher at California Institute of Technology
Publications - 882
Citations - 168784
David Baltimore is an academic researcher from California Institute of Technology. The author has contributed to research in topics: RNA & Virus. The author has an hindex of 203, co-authored 876 publications receiving 162955 citations. Previous affiliations of David Baltimore include Thomas Jefferson University & Johns Hopkins University.
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Book ChapterDOI
Defective Interfering Animal Viruses
Alice S. Huang,David Baltimore +1 more
TL;DR: Defective interfering particles were discovered three decades ago by von Magnus using the influenza virus system and a great deal was learned from their physiological interactions with the host and from their interference with the multiplication of “infectious” standard virus.
Journal ArticleDOI
Protein is linked to the 5' end of poliovirus RNA by a phosphodiester linkage to tyrosine.
Victor R. Ambros,David Baltimore +1 more
TL;DR: Purification and partial characterization of the poliovirus RNA-linked protein (VPg) are described and it is found that there appears to be only 1 tyrosine residue per VPg molecule.
Journal ArticleDOI
Distinct modes of human immunodeficiency virus type 1 proviral latency revealed by superinfection of nonproductively infected cell lines with recombinant luciferase-encoding viruses
TL;DR: Different modes of proviral latency are demonstrated in these two cell line models, which may have implications in the understanding of the regulation and significance of cellular latency in HIV infection.
Journal ArticleDOI
Ribonucleic Acid Synthesis of Vesicular Stomatitis Virus I. Species of Ribonucleic Acid Found in Chinese Hamster Ovary Cells Infected with Plaque-forming and Defective Particles
TL;DR: Observations begin to establish a molecular basis for understanding the ability of T particles to interfere with the growth of B particles in Chinese hamster ovary cells.
Journal ArticleDOI
CD4 down-modulation during infection of human T cells with human immunodeficiency virus type 1 involves independent activities of vpu, env, and nef.
TL;DR: HIV has three genes that are able to independently down-modulate CD4; together, they can eliminate the bulk of cell surface CD4.