D
David Baltimore
Researcher at California Institute of Technology
Publications - 882
Citations - 168784
David Baltimore is an academic researcher from California Institute of Technology. The author has contributed to research in topics: RNA & Virus. The author has an hindex of 203, co-authored 876 publications receiving 162955 citations. Previous affiliations of David Baltimore include Thomas Jefferson University & Johns Hopkins University.
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Journal ArticleDOI
Broadly Neutralizing Human Immunodeficiency Virus Type 1 Antibody Gene Transfer Protects Nonhuman Primates from Mucosal Simian-Human Immunodeficiency Virus Infection
Kevin O. Saunders,Lingshu Wang,M. Gordon Joyce,Zhi Yong Yang,Alejandro B. Balazs,Cheng Cheng,Sung Youl Ko,Wing Pui Kong,Rebecca S. Rudicell,Ivelin S. Georgiev,Lijie Duan,Kathryn E. Foulds,Mitzi M. Donaldson,Ling Xu,Stephen D. Schmidt,John Paul Todd,David Baltimore,Mario Roederer,Ashley T. Haase,Peter D. Kwong,Srinivas S. Rao,John R. Mascola,Gary J. Nabel +22 more
TL;DR: A proof-of-concept that gene transfer of anti-HIV antibody genes can protect against infection by viruses that cause AIDS in primates when host immune responses are controlled is shown.
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Phorbol-ester-induced activation of the NF-kappa B transcription factor involves dissociation of an apparently cytoplasmic NF-kappa B/inhibitor complex.
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An enzymatic activity in uninfected cells that cleaves the linkage between poliovirion RNA and the 5' terminal protein.
TL;DR: The 5' terminal protein (VPg) on poliovirion RNA can be removed by cell-free extracts from a variety of uninfected cells and the existence of this enzyme implies that poliovirus RNA is translated in cell- free extracts in a form that lacks the 5' terminals.
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T cell antigen discovery via signaling and antigen-presenting bifunctional receptors.
Alok V. Joglekar,Michael T. Leonard,John D. Jeppson,Margaret B. Swift,Guideng Li,Guideng Li,Stephanie Wong,Songming Peng,Jesse M. Zaretsky,James R. Heath,Antoni Ribas,Michael T. Bethune,David Baltimore +12 more
TL;DR: The use of chimeric receptors called signaling and antigen-presenting bifunctional receptors (SABRs) in a cell-based platform for T cell receptor (TCR) antigen discovery and extended this approach for personalized neoantigen discovery.
Journal Article
Regulation of 3' IgH enhancers by a common set of factors, including kappa B-binding proteins.
Jennifer Michaelson,Mallika Singh,Clifford M. Snapper,William C. Sha,David Baltimore,Barbara K. Birshtein +5 more
TL;DR: Kappa B binding proteins are identified as key modulators of 3'alpha E(hs1,2) and 3' alpha-hs4, the distal 3' IgH enhancer, and coregulation of the two enhancers by a common set of factors is suggested.