D
David Baltimore
Researcher at California Institute of Technology
Publications - 882
Citations - 168784
David Baltimore is an academic researcher from California Institute of Technology. The author has contributed to research in topics: RNA & Virus. The author has an hindex of 203, co-authored 876 publications receiving 162955 citations. Previous affiliations of David Baltimore include Thomas Jefferson University & Johns Hopkins University.
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Physiological functions for brain NF-κB
TL;DR: This review highlights advances in the understanding of the mechanisms of Ca 2+ -responsive activation and synaptic signaling to the nucleus by NF-κB transcription factors within the CNS, and the relevance of this transcription factor family for learning and memory.
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Targeted Mutation of TNF Receptor I Rescues the RelA-Deficient Mouse and Reveals a Critical Role for NF-κB in Leukocyte Recruitment
Elizabeth Alcamo,Joseph P. Mizgerd,Bruce H. Horwitz,Rod Bronson,Amer A. Beg,Martin L. Scott,Claire M. Doerschuk,Richard O. Hynes,David Baltimore +8 more
TL;DR: TNFR1-independent activation of RelA is essential in cells of nonhemopoietic origin during the initiation of an innate immune response in TNFR1/RelA-deficient mice.
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Radiation-induced Assembly of Rad51 and Rad52 Recombination Complex Requires ATM and c-Abl
Gang Chen,Shyng Shiou F Yuan,Wei Liu,Yang Xu,Kelly M. Trujillo,Binwei Song,Feng Cong,Stephen P. Goff,Yun Wu,Ralph B. Arlinghaus,David Baltimore,Paul J. Gasser,Min Soo Park,Patrick Sung,Eva Y.-H. P. Lee +14 more
TL;DR: This work demonstrates that there is an I-R-induced Rad51 tyrosine phosphorylation, and this induction is dependent on both ATM and c-Abl, and suggests signaling mediated through ATM is required for the correct post-translational modification of Rad51, which is critical for the assembly of Rad 51 repair protein complex following I- R.
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Neuronal pp60c-src contains a six-amino acid insertion relative to its non-neuronal counterpart
TL;DR: Brain c-src RNA contains an 18-nucleotide insertion at the position of the extra six amino acids within the NH2-terminal 16 kilodaltons of the molecule, which confirms that brain c- src RNA is encoded by a brain-specific messenger RNA.
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The recombination activating gene-1 (RAG-1) transcript is present in the murine central nervous system
TL;DR: The results suggest that RAG-1 functions in neurons, where its role might be to recombine elements of the neuronal genome site-specifically, or to prevent detrimental alterations of the genome in these long-lived cells.