D
David Baltimore
Researcher at California Institute of Technology
Publications - 882
Citations - 168784
David Baltimore is an academic researcher from California Institute of Technology. The author has contributed to research in topics: RNA & Virus. The author has an hindex of 203, co-authored 876 publications receiving 162955 citations. Previous affiliations of David Baltimore include Thomas Jefferson University & Johns Hopkins University.
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Journal ArticleDOI
Defective interfering particles of poliovirus. 3. Interference and enrichment.
Charles N. Cole,David Baltimore +1 more
TL;DR: In this article, the authors investigated interference with standard poliovirus growth resulting from co-infection of cells with standard virus and defective interfering particles and found that the interference results from equal participation in the intracellular events of the infection cycle by both types of particles.
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Multi-omic single-cell snapshots reveal multiple independent trajectories to drug tolerance in a melanoma cell line.
Yapeng Su,Yapeng Su,Melissa E. Ko,Hanjun Cheng,Ronghui Zhu,Min Xue,Min Xue,Jessica Wang,Jihoon W. Lee,Luke Frankiw,Alexander M. Xu,Stephanie Wong,Lidia Robert,Kaitlyn Takata,Dan Yuan,Yue Lu,Sui Huang,Antoni Ribas,Raphael D. Levine,Raphael D. Levine,Garry P. Nolan,Wei Wei,Wei Wei,Sylvia K. Plevritis,Guideng Li,David Baltimore,James R. Heath +26 more
TL;DR: It is uncovered that isogenic BRAF mutant melanoma cells can take two distinct paths to become tolerant to BRAF inhibition, thus updating the paradigm of adaptive resistance development in an isogenic cell population.
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Increased length of DNA made by virions of murine leukemia virus at limiting magnesium ion concentration.
TL;DR: Conditions have been developed for reverse transcription by detergent-disrupted virions of Moloney murine leukemia virus which permit synthesis of molecules that appear to be complete transcripts of the 35S RNA subunits.
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Reconstruction of the 1918 Influenza Virus: Unexpected Rewards from the Past
Jeffery K. Taubenberger,David Baltimore,Peter C. Doherty,Howard Markel,David M. Morens,Robert G. Webster,Ian A. Wilson +6 more
TL;DR: Recovery and sequence of highly degraded fragments of influenza viral RNA retained in preserved tissues from several 1918 victims eventually permitted reconstruction of the complete 1918 virus, which has yielded novel insights into influenza virus biology and pathogenesis.
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Generation of functional antigen-specific T cells in defined genetic backgrounds by retrovirus-mediated expression of TCR cDNAs in hematopoietic precursor cells
TL;DR: In this paper, retrovirus-mediated expression of T cell antigen receptor cDNAs in hematopoietic precursor cells has been used to generate antigen-specific T cells.