D
David Baltimore
Researcher at California Institute of Technology
Publications - 882
Citations - 168784
David Baltimore is an academic researcher from California Institute of Technology. The author has contributed to research in topics: RNA & Virus. The author has an hindex of 203, co-authored 876 publications receiving 162955 citations. Previous affiliations of David Baltimore include Thomas Jefferson University & Johns Hopkins University.
Papers
More filters
Journal ArticleDOI
Chimeric Nucleases Stimulate Gene Targeting in Human Cells
TL;DR: Homodimers of CNs are potent stimulators of gene targeting in human somatic cells and can stimulate homologous recombination by over 1000-fold.
Journal ArticleDOI
Circuitry of nuclear factor kappaB signaling.
TL;DR: The historical context is provided and the diverse physiological functions of NF‐κB in the immune system are summarized before focusing on recent advances in elucidating the molecular mechanisms that mediate cell type‐specific and stimulus‐specific functions of this pleiotropic signaling system.
Journal ArticleDOI
miR-146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice
Mark Boldin,Konstantin Taganov,Konstantin Taganov,Dinesh S. Rao,Dinesh S. Rao,Lili Yang,Jimmy L. Zhao,Manorama Kalwani,Yvette Garcia-Flores,Mui Luong,Asli Devrekanli,Jessica Xu,Guizhen Sun,Jia Tay,Peter S. Linsley,David Baltimore +15 more
TL;DR: Mice lacking miR-146a exhibit exaggerated inflammatory responses, autoimmunity, and increased rate of tumorigenesis.
Journal ArticleDOI
microRNA Regulation of Inflammatory Responses
TL;DR: Recent advances in the understanding of miRNAs and their connection to inflammatory responses are discussed, and the link between perturbations in miRNA levels and the onset of human inflammatory diseases is considered.
Journal ArticleDOI
Inositol phosphatase SHIP1 is a primary target of miR-155.
TL;DR: This study unveils a molecular link between miR-155 and SHIP1 and provides evidence that repression ofSHIP1 is an important component of miR -155 biology.