D
David Baltimore
Researcher at California Institute of Technology
Publications - 882
Citations - 168784
David Baltimore is an academic researcher from California Institute of Technology. The author has contributed to research in topics: RNA & Virus. The author has an hindex of 203, co-authored 876 publications receiving 162955 citations. Previous affiliations of David Baltimore include Thomas Jefferson University & Johns Hopkins University.
Papers
More filters
Journal ArticleDOI
Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles.
Warren S. Pear,Jon C. Aster,Martin L. Scott,Robert P. Hasserjian,Benny Soffer,Jeffrey Sklar,David Baltimore +6 more
TL;DR: Results show that TAN1 is an oncoprotein and suggest that truncation and overexpression are important determinants of transforming activity in hematopoietic cells.
Journal ArticleDOI
Ordered rearrangement of immunoglobulin heavy chain variable region segments.
Frederick W. Alt,George D. Yancopoulos,T K Blackwell,Charles E. Wood,Elise Thomas,Michael Alan Boss,Robert L. Coffman,Naomi Rosenberg,Susumu Tonegawa,David Baltimore +9 more
TL;DR: Results support an ordered mechanism of variable gene assembly during B‐cell differentiation in which D‐to‐JH rearrangements generally occur first and on both chromosomes followed by VH‐to-DJH rearranged, with both types of joining processes occurring by intrachromosomal deletion.
Journal ArticleDOI
Cloned poliovirus complementary DNA is infectious in mammalian cells
TL;DR: A complete, cloned complementary DNA copy of the RNA genome of poliovirus was constructed in the Pst I site of the bacterial plasmid pBR322 and Cultured mammalian cells transfected with this hybrid plasmids produced infectious poliov virus.
Journal ArticleDOI
The POU domain: a large conserved region in the mammalian pit-1, oct-1, oct-2, and Caenorhabditis elegans unc-86 gene products
Winship Herr,Richard A. Sturm,Roger G. Clerc,Lynn M. Corcoran,David Baltimore,Phillip A. Sharp,Holly A. Ingraham,Michael G. Rosenfeld,Michael Finney,Gary Ruvkun +9 more
TL;DR: The POU domain is a novel bipartite DNA-binding structure in which the POU homoeo and POU-specific regions form two subdomains that are both required for DNA binding but are held together by a flexible linker.
Journal ArticleDOI
Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusions.
Frederick W. Alt,David Baltimore +1 more
TL;DR: It is suggested that this added sequence is a product of the activity of terminal deoxynucleotidyltransferase at the D/JH (and probably the VH/D) joints and that it represents a new element of heavy chain gene structure, the N region.