D
David Baltimore
Researcher at California Institute of Technology
Publications - 882
Citations - 168784
David Baltimore is an academic researcher from California Institute of Technology. The author has contributed to research in topics: RNA & Virus. The author has an hindex of 203, co-authored 876 publications receiving 162955 citations. Previous affiliations of David Baltimore include Thomas Jefferson University & Johns Hopkins University.
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Activation of phosphatidylinositol 3-kinase in cells expressing abl oncogene variants.
TL;DR: Myristoylation appears to be required to recruit PI 3-kinase activity to the plasma membrane for in vivo activation and correlates with the mitogenicity of the abl protein variants.
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Adoptive Transfer of MART-1 T-Cell Receptor Transgenic Lymphocytes and Dendritic Cell Vaccination in Patients with Metastatic Melanoma
Thinle Chodon,Thinle Chodon,Begonya Comin-Anduix,Bartosz Chmielowski,Richard C. Koya,Richard C. Koya,Zhongqi Wu,Martin Auerbach,Charles Ng,Earl Avramis,Elizabeth Seja,Arturo Villanueva,Tara A. McCannel,Akira Ishiyama,Johannes Czernin,Caius G. Radu,Xiaoyan Wang,David W. Gjertson,Alistair J. Cochran,Kenneth Cornetta,Deborah J.L. Wong,Paula Kaplan-Lefko,Omid Hamid,Wolfram E. Samlowski,Peter A. Cohen,Gregory A. Daniels,Bijay Mukherji,Lili Yang,Jerome A. Zack,Donald B. Kohn,James R. Heath,John A. Glaspy,Owen N. Witte,David Baltimore,James S. Economou,Antoni Ribas +35 more
TL;DR: Double cell therapy with ACT of TCR-engineered T cells with a very short ex vivo manipulation and DC vaccines is feasible and results in antitumor activity, but improvements are needed to maintain tumor responses.
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Patterns of macromolecular synthesis in normal and virus-infected mammalian cells.
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Increased frequency of N-region insertion in a murine pre-B-cell line infected with a terminal deoxynucleotidyl transferase retroviral expression vector.
TL;DR: It is evident that TdT can stimulate N-region insertion, and the enzyme is presumably directly responsible for adding nucleotides at V-J and other immunoglobulin and T-cell receptor gene junctions.
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Encoding NF-κB temporal control in response to TNF: distinct roles for the negative regulators IκBα and A20
Shannon L. Werner,Jeffrey D. Kearns,Victoria Zadorozhnaya,Candace Lynch,Ellen O'Dea,Mark Boldin,Averil Ma,David Baltimore,Alexander Hoffmann +8 more
TL;DR: The results delineate the nonredundant functions implied by the knockout phenotypes of ikappabalpha and a20, and identify the latter as a signaling cross-talk mediator controlling inflammatory and developmental responses.