D
David Baltimore
Researcher at California Institute of Technology
Publications - 882
Citations - 168784
David Baltimore is an academic researcher from California Institute of Technology. The author has contributed to research in topics: RNA & Virus. The author has an hindex of 203, co-authored 876 publications receiving 162955 citations. Previous affiliations of David Baltimore include Thomas Jefferson University & Johns Hopkins University.
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Abelson virus abrogation of interleukin-3 dependence in a lymphoid cell line.
TL;DR: Among several tyrosine-protein kinases, only v-abl could abrogate interleukin 3 dependence of a lymphoblastoid cell line; v-src and v-fps proteins gave partial or no interLEUKin 3 independence, respectively as discussed by the authors.
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Regulated expression of an immunoglobulin kappa gene introduced into a mouse lymphoid cell line.
Douglas Rice,David Baltimore +1 more
TL;DR: A functionally rearranged murine kappa light chain immunoglobulin (Ig) gene is introduced into an Abelson murine leukemia virus-transformed lymphoid cell line and levels of kappa mRNA and polypeptide increased, showing regulated expression of the introduced kappa gene.
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Requirement of 3'-terminal poly(adenylic acid) for the infectivity of poliovirus RNA.
TL;DR: Ribonuclease H (EC 3.4.1.34) has been used to remove selectively much of the 3'-terminal poly(adenylic acid) [poly(A)] from poliovirus RNA by treating the RNA with the enzyme in the presence of poly(dT), indicating that poly(A) is necessary to the infectivity of the RNA.
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Binding of Vav to Grb2 through dimerization of Src homology 3 domains
Zheng-Sheng Ye,David Baltimore +1 more
TL;DR: It is reported that both in cell extracts and within intact mammalian cells Vav binds to Grb2 (Sem-5/ASH/Drk), an adaptor molecule which plays a key role in Ras activation.
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Somatic variants of murine immunoglobulin lambda light chains.
Alfred L. M. Bothwell,Michael Paskind,Michael Reth,Thereza Imanishi-Kari,Klaus Rajewsky,David Baltimore +5 more
TL;DR: The nucleotide sequence of two λ 1 gene from hybridomas and a λ 2 gene from a myeloma are determined to demonstrate that somatic mutation in λ genes can occur in both the framework and CDR residues.