D
David Baltimore
Researcher at California Institute of Technology
Publications - 882
Citations - 168784
David Baltimore is an academic researcher from California Institute of Technology. The author has contributed to research in topics: RNA & Virus. The author has an hindex of 203, co-authored 876 publications receiving 162955 citations. Previous affiliations of David Baltimore include Thomas Jefferson University & Johns Hopkins University.
Papers
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Journal ArticleDOI
The IκB-NF-κB Signaling Module: Temporal Control and Selective Gene Activation
TL;DR: A computational model is presented that describes the temporal control of NF-κB activation by the coordinated degradation and synthesis of IκB proteins and demonstrates that IπκBα is responsible for strong negative feedback that allows for a fast turn-off of the NF-σB response.
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Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence.
Cornelis Murre,Patrick S. McCaw,H. Vaessin,M. Caudy,Lily Yeh Jan,Yuh Nung Jan,Carlos V. Cabrera,Jean N. Buskin,Stephen D. Hauschka,Andrew B. Lassar,Harold Weintraub,David Baltimore +11 more
TL;DR: The HLH domain can mediate heterodimer formation between either daughterless, E12, or E47 and achaete-scute T3 or MyoD to form proteins with high affinity for the kappa E2 site in the immunoglobulin kappa chain enhancer.
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NF-κB: A pleiotropic mediator of inducible and tissue-specific gene control
TL;DR: Comment intervient le NF-kB, quels sont les systemes dans lesquels il joue un role, tels que les messages intracellulaires, l'activation des cellules C, the regulation of the cytokinine, ou encore l'utilisation par les virus
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The “initiator” as a transcription control element
Stephen T. Smale,David Baltimore +1 more
TL;DR: The Inr constitutes the simplest functional promoter that has been identified and provides one explanation for how promoters that lack TATA elements direct transcription initiation.
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Physiological and pathological roles for microRNAs in the immune system
TL;DR: Recent advances in understanding of both the intended functions of miRNAs in managing immune cell biology and their pathological roles when their expression is dysregulated are discussed.