D
David Baltimore
Researcher at California Institute of Technology
Publications - 882
Citations - 168784
David Baltimore is an academic researcher from California Institute of Technology. The author has contributed to research in topics: RNA & Virus. The author has an hindex of 203, co-authored 876 publications receiving 162955 citations. Previous affiliations of David Baltimore include Thomas Jefferson University & Johns Hopkins University.
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Hamster Leukemia Virus: Lack of Endogenous DNA Synthesis and Unique Structure of Its DNA Polymerase
TL;DR: The HaLV enzyme appears to be structurally distinct from other known virion DNA polymerases, and its inability to carry out an endogenous reaction in vitro might result from an inability to utilize certain primers.
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Defective interfering particles of poliovirus. IV. Mechanisms of enrichment.
Charles N. Cole,David Baltimore +1 more
TL;DR: Study of the cycloheximide effect showed that the drug acted as if to change the input ratio of standard to DI particles, and enrichment due to preferential encapsidation of DI RNA can be explained as aspects of two different phenomena.
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Dual mechanisms of posttranscriptional regulation of Tet2 by Let-7 microRNA in macrophages
TL;DR: A physiological role of the microRNA let-7adf cluster is to promote IL-6 secretion by lipopolysaccharide-activated macrophages through down-regulating Tet2, thus characterizing a regulatory pathway in which a microRNA acts as a feedback inhibitor of inflammatory processes.
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Separation and quantitation of intracellular forms of poliovirus RNA by agarose gel electrophoresis.
TL;DR: Intracellular poliovirus-specific RNA species can be measured directly by electrophoresis of total cytoplasmic nucleic acids through 1% agarose gels, resulting in the separation of single- and double-stranded forms of poliov virus RNA from each other and from HeLa cell 28S ribosomal RNA.
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MATE-Seq: microfluidic antigen-TCR engagement sequencing
Alphonsus H. C. Ng,Alphonsus H. C. Ng,Songming Peng,Alexander M. Xu,Alexander M. Xu,Won Jun Noh,Katherine Guo,Michael T. Bethune,William Chour,William Chour,Jongchan Choi,Jongchan Choi,Sung Yang,David Baltimore,James R. Heath +14 more
TL;DR: A method that selectively labels peptide antigen-specific CD8+ T cells using magnetic nanoparticles functionalized with peptide-MHC tetramers, isolates these specific cells within an integrated microfluidic device, and directly amplifies the TCR genes for sequencing is presented.