F
Feng Zhang
Researcher at Fudan University
Publications - 2715
Citations - 225233
Feng Zhang is an academic researcher from Fudan University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 172, co-authored 1278 publications receiving 181865 citations. Previous affiliations of Feng Zhang include Cincinnati Children's Hospital Medical Center & Nanjing Medical University.
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Patent
Crispr effector system based diagnostics for virus detection
Omar O. Abudayyeh,James Joseph Collins,Jonathan S. Gootenberg,Feng Zhang,Eric S. Lander,Pardis C. Sabeti,Catherine A. Freije,Cameron Myhrvold +7 more
TL;DR: In this article, a nucleic acid detection system comprising of a CRISPR system comprising an effector protein and one or more guide RNAs designed to bind to corresponding target molecules; an RNA-based masking construct; and optionally, NCA amplification reagents to amplify target RNA molecules in a sample.
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CNV instability associated with DNA replication dynamics: evidence for replicative mechanisms in CNV mutagenesis
TL;DR: An estimation of DNA replication dynamics, as the statistic R, is conducted using the readily available data of replication timing to suggest an important role for DNA replicative mechanisms in CNV mutagenesis and genome instability.
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Triple expression of B7-1, B7-2 and 4-1BBL enhanced antitumor immune response against mouse H22 hepatocellular carcinoma.
Guoqiang Li,Xiaofeng Wu,Feng Zhang,Xiangcheng Li,Beicheng Sun,Yue Yu,Aihong Yin,Lei Deng,Jie Yin,Xuehao Wang +9 more
TL;DR: Results showed that H22/B 7-1/B7-2/4-1BBL tumor vaccines probably protect the infiltrating lymphocytes from apoptosis and induce NF-κB activation to improve T-cell-mediated antitumor response.
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Propane σ‐Complexes on PdO(101): Spectroscopic Evidence of the Selective Coordination and Activation of Primary CH Bonds
TL;DR: It is shown that a propane molecule achieves maximum stability on PdO(101) by adopting a bidentate geometry in which a H-Pd dative bond forms at each CH3 group, and that structural registry between the molecule and surface can strongly influence the selectivity of a metal oxide surface in activating alkane C-H bonds.
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Bi-allelic SHOC1 loss-of-function mutations cause meiotic arrest and non-obstructive azoospermia.
Chencheng Yao,Chao Yang,Liangyu Zhao,Peng Li,Ruhui Tian,Huixing Chen,Ying Guo,Yuhua Huang,Erlei Zhi,Jing Zhai,Hongfang Sun,Zhang Jianxiong,Yan Hong,Li Zhang,Zhiyong Ji,Feng Zhang,Zhi Zhou,Zheng Li,Zheng Li +18 more
TL;DR: To the best of the authors' knowledge, this is the first report identifying SHOC1 as the causative gene for human NOA and showing an autosomal recessive mode of inheritance in the NOA caused by SH OC1 deficiency.