F
Feng Zhang
Researcher at Fudan University
Publications - 2715
Citations - 225233
Feng Zhang is an academic researcher from Fudan University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 172, co-authored 1278 publications receiving 181865 citations. Previous affiliations of Feng Zhang include Cincinnati Children's Hospital Medical Center & Nanjing Medical University.
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Journal ArticleDOI
Adopt a moratorium on heritable genome editing
Eric S. Lander,Françoise Baylis,Feng Zhang,Emmanuelle Charpentier,Paul Berg,Catherine Bourgain,Bärbel Friedrich,J. Keith Joung,Jinsong Li,David R. Liu,Luigi Naldini,Jing-Bao Nie,Renzong Qiu,Bettina Schoene-Seifert,Feng Shao,Sharon F. Terry,Wensheng Wei,Ernst-Ludwig Winnacker +17 more
TL;DR: Eric Lander, Françoise Baylis, Feng Zhang, Emmanuelle Charpentier, Paul Berg and specialists from seven countries call for an international governance framework.
Journal ArticleDOI
CRISPR-Based Therapeutic Genome Editing: Strategies and In Vivo Delivery by AAV Vectors.
TL;DR: CRISPR-based strategies to improve human health, with an emphasis on the delivery of CRISPR therapeutics directly into the human body using adeno-associated virus (AAV) vectors are described.
Journal ArticleDOI
Schizophrenia-Related Neural and Behavioral Phenotypes in Transgenic Mice Expressing Truncated Disc1
Sanbing Shen,Bing Lang,Chizu Nakamoto,Feng Zhang,Jin Pu,Soh Leh Kuan,Christina Chatzi,Shuisheng He,Iain Mackie,Nicholas J. Brandon,Karen L. Marquis,Mark Day,Orest Hurko,Orest Hurko,Colin D. McCaig,Gernot Riedel,David St Clair +16 more
TL;DR: Disrupted-in-Schizophrenia-1 transgenic mice exhibit increased immobility and reduced vocalization in depression-related tests, and impairment in conditioning of latent inhibition, consistent with findings in severe schizophrenia.
Journal ArticleDOI
Complex human chromosomal and genomic rearrangements
TL;DR: Copy number variation (CNV) is a major source of genetic variation among humans and in addition to existing as benign polymorphisms, CNVs can also convey clinical phenotypes, including genomic disorders, sporadic diseases and complex human traits.
Journal ArticleDOI
Mice with Shank3 Mutations Associated with ASD and Schizophrenia Display Both Shared and Distinct Defects
Yang Zhou,Yang Zhou,Tobias Kaiser,Patricia Monteiro,Patricia Monteiro,Patricia Monteiro,Xiangyu Zhang,Marie Sophie van der Goes,Dongqing Wang,Boaz Barak,Menglong Zeng,Menglong Zeng,Chenchen Li,Chenchen Li,Congyi Lu,Congyi Lu,Michael F. Wells,Michael F. Wells,Aldo Amaya,Shannon Nguyen,Michael C. Lewis,Neville E. Sanjana,Neville E. Sanjana,Yongdi Zhou,Mingjie Zhang,Feng Zhang,Zhanyan Fu,Zhanyan Fu,Guoping Feng,Guoping Feng,Guoping Feng +30 more
TL;DR: In this paper, the authors characterized two lines of mutant mice with Shank3 mutations linked to ASD and schizophrenia and found both shared and distinct synaptic and behavioral phenotypes, which may inform exploration of these relationships in human patients.