F
Feng Zhang
Researcher at Fudan University
Publications - 2715
Citations - 225233
Feng Zhang is an academic researcher from Fudan University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 172, co-authored 1278 publications receiving 181865 citations. Previous affiliations of Feng Zhang include Cincinnati Children's Hospital Medical Center & Nanjing Medical University.
Papers
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Journal ArticleDOI
Alu-specific microhomology-mediated deletion of the final exon of SPAST in three unrelated subjects with hereditary spastic paraplegia.
Philip M. Boone,Pengfei Liu,Feng Zhang,Claudia M.B. Carvalho,Charles F. Towne,Sat Dev Batish,James R. Lupski,James R. Lupski +7 more
TL;DR: It is proposed that genomic deletions encompassing the final exon of SPAST may affect expression of SLC30A6, the most proximal downstream locus and a gene that has been implicated in the pathogenesis of Alzheimer disease, potentially explaining recent reports of dementia in selected SPG4 patients.
Book ChapterDOI
RNA-guided genome editing of mammalian cells.
TL;DR: A protocol for the use of the RNA-guided Cas9 nuclease from the Streptococcus pyogenes type II CRISPR system to achieve specific, scalable, and cost-efficient genome editing in mammalian cells is described.
Journal ArticleDOI
Polyphyllin VI, a saponin from Trillium tschonoskii Maxim. induces apoptotic and autophagic cell death via the ROS triggered mTOR signaling pathway in non-small cell lung cancer.
Jin-Feng Teng,Dalian Qin,Qibing Mei,Wen-Qiao Qiu,Rong Pan,Rui Xiong,Ya Zhao,Betty Yuen Kwan Law,Vincent Kam Wai Wong,Yong Tang,Chong-Lin Yu,Feng Zhang,Jianming Wu,An-Guo Wu +13 more
TL;DR: It is demonstrated that PPVI is the main component in TTM that exerts the anti-proliferative effect by inducing apoptotic and autophagic cell death in NSCLC via the ROS-triggered mTOR signaling pathway, and PPVI may be a promising candidate for the treatment ofNSCLC in future.
Journal ArticleDOI
Xanthatin Induces Cell Cycle Arrest at G2/M Checkpoint and Apoptosis via Disrupting NF-κB Pathway in A549 Non-Small-Cell Lung Cancer Cells
Lei Zhang,Junshan Ruan,Linggeng Yan,Weidong Li,Yu Wu,Li Tao,Feng Zhang,Shizhong Zheng,Aiyun Wang,Yin Lu +9 more
TL;DR: It is concluded that xanthatin displays significant antitumor effects through cell cycle arrest and apoptosis induction in A549 cells, associated with intrinsic apoptosis pathway and disrupted NF-κB signaling.
Journal ArticleDOI
Structural model of channelrhodopsin
Hiroshi Watanabe,Kai Welke,Franziska Schneider,Satoshi P. Tsunoda,Feng Zhang,Karl Deisseroth,Peter Hegemann,Marcus Elstner +7 more
TL;DR: A structural ChR model is developed based on characteristic patterns in amino acid sequences of ChR1, ChR2, Volvox ChRs, Mesostigma ChR, and the recently identified ChR of the halophilic alga Dunaliella salina, and in a crucial validation of the model, it successfully reproduce the excitation energy predicted by absorption spectra.