Feng Zhang

TL;DR: Testing the hypothesis that IMD in the PVN can inhibit the generation of ROS caused by Ang II for attenuating sympathetic nerve activity (SNA) and blood pressure (BP) in rats with obesity-related hypertension (OH) indicated that IMd via AM receptors in the MVN attenuates SNA and hypertension, and decreases Ang II-induced enhancement of SNA through the inhibition of NADPH oxidase activity and ERK activation.

TL;DR: In this paper, a combined cooling, heating and power (CCHP) system consisting of a supercritical carbon dioxide (sCO2) power cycle, a transcritical CO2 power cycle with a carbon dioxide based refrigeration cycle, and a direct heating (DH) system is proposed.

TL;DR: It is suggested that chronic hypoxia-induced mitochondrial damage and apoptosis might play an important role in the pathogenesis of Kashin-Beck Disease.

TL;DR: In this paper , the authors performed a genome-scale CRISPR activation screen for genes that enable human melanoma cells to evade cytotoxic T cell killing, and they found that the genes that enabled resistance to immunotherapy were CD274 (PD-L1), MCL1, JUNB, and B3GNT2.

TL;DR: It is found that short-term starvation attenuates liver IRI via the Sirt1-autophagy pathway, and this findings provide a rationale for a novel therapeutic strategy for managing liver I RI.