Feng Zhang

TL;DR: This study provides new evidence for the protective effects of NAC treatment on hepatocytes during IRI through inhibition of ROS-mediated ER stress, NAC may be critical to inhibit the ER-stress-related apoptosis pathway.

TL;DR: AAV-mediated autochthonous CRISPR screens provide a powerful means for mapping a provisional functional cancer genome atlas of tumor suppressors in vivo, revealing the functional consequence of multiple variants in driving liver tumorigenesis in immunocompetent mice.

TL;DR: Results indicate that salusin-β promotes VSMC proliferation via cAMP-PKA-EGFR-CREB/ERK pathway and vascular fibrosis via TGF-β1-Smad pathway and contributes to vascular remodeling and hypertension.

TL;DR: In this paper, the dystrobrevin-binding protein 1 (DTNBP1) gene on chromosome 6p has emerged as a potential susceptibility gene for schizophrenia, and a number of attempts to replicate the original association finding have been successful, they have not identified any obvious pathogenic variants or a single at risk haplotype common to all populations studied.

TL;DR: It is indicated that salusin-β contributes to inflammation in DCM via NOX2/ROS/NFκB signaling, and that knockdown of salusIn-β attenuates cardiac dysfunction, oxidative stress and inflammation inDCM.