Feng Zhang

TL;DR: A combination of triple-compound heterozygous variants was identified in a family affected by a heart disease, and was further verified in a mouse model by zygotic injection of CRISPR-Cas9 system followed by multiple generations of intercrossing, revealing the joint contributions of gene variants to the etiology of complex diseases.

TL;DR: In this article , Tb3+−doped Ba2LaF7 nanocrystals (NCs) grown in situ and dispersed uniformly in an amorphous glass matrix are explored, which performs a fascinating X-ray response for imaging with an impressive spatial resolution reaching 20.0 lp mm−1.

TL;DR: Multiple candidate genes and GO terms were detected for chondropathies and the protein expression level of DDX20 was significantly different between knee OA cartilage and healthy control cartilage, which may provide a novel insight in the molecular mechanisms of chondopathies.

TL;DR: In this paper , the effects of nanoplastics and ZnO nanoparticles on plant growth were investigated for 10 days, and the results indicated that the modulations in protein phosphorylation were closely related to the physiological responses to nanomaterial exposure, suggesting that the co-existence of nanoparticles may lead to greater impacts than single ones.

TL;DR: The results suggest that the combination of MBD2 and IL-18 induces more effective antileukemia activity and provides a promising strategy for cancer therapy.