F
Feng Zhang
Researcher at Fudan University
Publications - 2715
Citations - 225233
Feng Zhang is an academic researcher from Fudan University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 172, co-authored 1278 publications receiving 181865 citations. Previous affiliations of Feng Zhang include Cincinnati Children's Hospital Medical Center & Nanjing Medical University.
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Tal effector-mediated dna modification
TL;DR: In this paper, the authors present a method for gene targeting with transcription activator-like effector nucleases (TALENS) and discuss its application in the field of bioinformatics.
Journal ArticleDOI
Crystal Structure of Staphylococcus aureus Cas9
Hiroshi Nishimasu,Hiroshi Nishimasu,Le Cong,Winston X. Yan,F. Ann Ran,F. Ann Ran,Bernd Zetsche,Yinqing Li,Arisa Kurabayashi,Ryuichiro Ishitani,Feng Zhang,Osamu Nureki +11 more
TL;DR: In this paper, the crystal structures of SaCas9 with a single guide RNA (sgRNA) and its double-stranded DNA targets, containing the 5'-TTGAAT-3' PAM and the 5"-TTGGGT-3" PAM, at 2.6 and 2.7 A resolutions, respectively, were reported.
Journal ArticleDOI
Common Genetic Variants Modulate Pathogen-Sensing Responses in Human Dendritic Cells
Mark Lee,Mark Lee,Chun Ye,Alexandra-Chloé Villani,Alexandra-Chloé Villani,Towfique Raj,Towfique Raj,Towfique Raj,Weibo Li,Weibo Li,Thomas Eisenhaure,Thomas Eisenhaure,Selina Imboywa,Portia Chipendo,F. Ann Ran,Kamil Slowikowski,Lucas D. Ward,Khadir Raddassi,Cristin McCabe,Cristin McCabe,Michelle Lee,Irene Y. Frohlich,David A. Hafler,Manolis Kellis,Soumya Raychaudhuri,Feng Zhang,Feng Zhang,Barbara E. Stranger,Christophe Benoist,Philip L. De Jager,Philip L. De Jager,Philip L. De Jager,Aviv Regev,Aviv Regev,Nir Hacohen,Nir Hacohen +35 more
TL;DR: In this paper, the effects of genetic variation on the induction of pathogen-responsive genes in human dendritic cells were investigated using a set of 121 common genetic variants associated in cis with variation in expression responses to Escherichia coli lipopolysaccharide, influenza, or interferon-β (IFN-β).
Journal ArticleDOI
Improved soybean oil quality by targeted mutagenesis of the fatty acid desaturase 2 gene family
William J. Haun,Andrew Coffman,Benjamin M. Clasen,Zachary L. Demorest,Anita Lowy,Erin E. Ray,Adam Retterath,Thomas Stoddard,Alexandre Juillerat,Frederic Cedrone,Luc Mathis,Daniel F. Voytas,Feng Zhang +12 more
TL;DR: The ability to create a valuable trait in a single generation through targeted modification of a gene family demonstrates the power of TALENs for genome engineering and crop improvement.
Journal ArticleDOI
Cas13b Is a Type VI-B CRISPR-Associated RNA-Guided RNase Differentially Regulated by Accessory Proteins Csx27 and Csx28
Aaron Smargon,David Benjamin Turitz Cox,Neena Pyzocha,Kaijie Zheng,Kaijie Zheng,Kaijie Zheng,Ian Slaymaker,Ian Slaymaker,Ian Slaymaker,Jonathan S. Gootenberg,Omar Abudayyeh,Patrick Essletzbichler,Patrick Essletzbichler,Patrick Essletzbichler,Sergey Shmakov,Sergey Shmakov,Kira S. Makarova,Eugene V. Koonin,Feng Zhang +18 more
TL;DR: It is established that two class 2 CRISPR-Cas systems that lack Cas1 and Cas2 and encompass a single large effector protein, Cas13b, along with one of two previously uncharacterized associated proteins, can achieve RNA interference when heterologously expressed.