F
Feng Zhang
Researcher at Fudan University
Publications - 2715
Citations - 225233
Feng Zhang is an academic researcher from Fudan University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 172, co-authored 1278 publications receiving 181865 citations. Previous affiliations of Feng Zhang include Cincinnati Children's Hospital Medical Center & Nanjing Medical University.
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Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA
Hiroshi Nishimasu,Naoshi Dohmae,Ryuichiro Ishitani,Osamu Nureki,Fei Ran,Patrick D. Hsu,Silvana Konermann,Soraya I. Shehata,Feng Zhang +8 more
TL;DR: The crystal structure of Streptococcus pyogenes Cas9 in complex with sgRNA and its target DNA at 2.5 Å resolution and accompanying functional analyses have revealed the molecular mechanism of RNA-guided DNA targeting by Cas9, paving the way for the rational design of new, versatile genome-editing technologies.
Journal ArticleDOI
RNA targeting with CRISPR-Cas13.
Omar O. Abudayyeh,Jonathan S. Gootenberg,Patrick Essletzbichler,Shuo Han,Julia Joung,Joseph J. Belanto,Vanessa Verdine,David Benjamin Turitz Cox,Max J. Kellner,Aviv Regev,Aviv Regev,Eric S. Lander,Eric S. Lander,Eric S. Lander,Daniel F. Voytas,Alice Y. Ting,Feng Zhang +16 more
TL;DR: It is demonstrated that the class 2 type VI RNA-guided RNA-targeting CRISPR–Cas effector Cas13a (previously known as C2c2) can be engineered for mammalian cell RNA knockdown and binding and is established as a flexible platform for studying RNA in mammalian cells and therapeutic development.
CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling
Randall Jeffrey Platt,Sidi Chen,Yang Zhou,Michael Yim,Lukasz Swiech,Hannah R. Kempton,James E. Dahlman,Oren Parnas,Thomas Eisenhaure,Marko Jovanovic,Daniel B. Graham,Siddharth Jhunjhunwala,Matthias Heidenreich,Ramnik J. Xavier,Robert Langer,Daniel G. Anderson,Nir Hacohen,Aviv Regev,Guoping Feng,Phillip A. Sharp,Feng Zhang +20 more
TL;DR: In this paper, a Cre-dependent Cas9 knockin mouse was used to study the dynamics of KRAS, p53, and LKB1, the top three significantly mutated genes in lung adenocarcinoma.
Journal ArticleDOI
Genome-wide association study identifies eight loci associated with blood pressure
Christopher Newton-Cheh,Christopher Newton-Cheh,Toby Johnson,Toby Johnson,Vesela Gateva,Martin D. Tobin,Murielle Bochud,Lachlan J. M. Coin,Samer S. Najjar,Jing Hua Zhao,Simon Heath,Susana Eyheramendy,Konstantinos A. Papadakis,Benjamin F. Voight,Benjamin F. Voight,Laura J. Scott,Feng Zhang,Martin Farrall,Toshiko Tanaka,Toshiko Tanaka,Chris Wallace,Chris Wallace,John C. Chambers,Kay-Tee Khaw,Peter M. Nilsson,Pim van der Harst,Silvia Polidoro,Diederick E. Grobbee,N. Charlotte Onland-Moret,N. Charlotte Onland-Moret,Michiel L. Bots,Louise V. Wain,Katherine S. Elliott,Alexander Teumer,Jian'an Luan,Gavin Lucas,Johanna Kuusisto,Paul Burton,David Hadley,Wendy L. McArdle,Morris J. Brown,Anna F. Dominiczak,Stephen Newhouse,Nilesh J. Samani,John Webster,Eleftheria Zeggini,Eleftheria Zeggini,Jacques S. Beckmann,Sven Bergmann,Sven Bergmann,Noha Lim,Kijoung Song,Peter Vollenweider,Gérard Waeber,Dawn M. Waterworth,Xin Yuan,Leif Groop,Marju Orho-Melander,Alessandra Allione,Alessandra Di Gregorio,Simonetta Guarrera,Salvatore Panico,Fulvio Ricceri,Valeria Romanazzi,Carlotta Sacerdote,Paolo Vineis,Inês Barroso,Manjinder S. Sandhu,Manjinder S. Sandhu,Robert Luben,Gabriel Crawford,Pekka Jousilahti,Markus Perola,Markus Perola,Michael Boehnke,Lori L. Bonnycastle,Francis S. Collins,Anne U. Jackson,Karen L. Mohlke,Heather M. Stringham,Timo T. Valle,Cristen J. Willer,Richard N. Bergman,Mario A. Morken,Angela Döring,Christian Gieger,Thomas Illig,Thomas Meitinger,Elin Org,Arne Pfeufer,H.-Erich Wichmann,Sekar Kathiresan,Sekar Kathiresan,Jaume Marrugat,Christopher J. O'Donnell,Christopher J. O'Donnell,Stephen M. Schwartz,David S. Siscovick,Isaac Subirana,Nelson B. Freimer,Anna-Liisa Hartikainen,Mark I. McCarthy,Paul F. O'Reilly,Leena Peltonen,Leena Peltonen,Anneli Pouta,Anneli Pouta,Paul E. de Jong,Harold Snieder,Wiek H. van Gilst,Robert Clarke,Anuj Goel,Anders Hamsten,David Altshuler,David Altshuler,Marjo Ritta Jarvelin,Marjo Ritta Jarvelin,Marjo Ritta Jarvelin,Paul Elliott,Edward G. Lakatta,Nita G. Forouhi,Nicholas J. Wareham,Ruth J. F. Loos,Panos Deloukas,Sheila Bingham,Diana Zelenika,David P. Strachan,Nicole Soranzo,Nicole Soranzo,Frances M K Williams,Guangju Zhai,Tim D. Spector,John F. Peden,Hugh Watkins,Luigi Ferrucci,Mark J. Caulfield,Patricia B. Munroe,Göran Berglund,Olle Melander,Guiseppe Matullo,Cuno S. P. M. Uiterwaal,Yvonne T. van der Schouw,Mattijs E. Numans,Florian Ernst,Georg Homuth,Uwe Völker,Roberto Eluosa,Markku Laakso,John M. C. Connell,Vincent Mooser,Veikko Salomaa,Jaakko Tuomilehto,Jaakko Tuomilehto,Maris Laan,Gerjan Navis,Udo Seedorf,Ann-Christine Syvänen,Giovanni Tognoni,Serena Sanna,Manuela Uda,Paul Scheet,David Schlessinger,Angelo Scuteri,Marcus Dörr,Stephan B. Felix,Thorsten Reffelmann,Roberto Lorbeer,Henry Völzke,Rainer Rettig,Pilar Galan,Serge Hercberg,Jaspal S. Kooner,Stefania Bandinelli,Pierre Meneton,Gonçalo R. Abecasis,John R. Thompson,Carolina A. Braga Marcano,Beverley Barke,Richard Dobson,Johannie Gungadoo,Kate L. Lee,Abiodun Onipinla,I. Wallace,Mingzhan Xue,David Clayton,H. T. Leung,Sarah Nutland,Neil Walker,John A. Todd,Helen Stevens,David B. Dunger,Barry Widmer,Kate Downes,Kate Downes,Lou R. Cardon,Dominic P. Kwiatkowski,Dominic P. Kwiatkowski,Jeffrey C. Barrett,David M. Evans,Andrew P. Morris,Cecilia M. Lindgren,Nigel W. Rayner,N J Timpson,N J Timpson,Emily J. Lyons,Fredrik O. Vannberg,Adrian V. S. Hill,Yik Ying Teo,Kirk A. Rockett,Nicholas John Craddock,Antony P. Attwood,Antony P. Attwood,Claire Bryan,Suzannah Bumpstead,Amy Chaney,Jilur Ghori,Rhian G. William,Sarah E. Hunt,Michael Inouye,Emma Keniry,Emma King,Ralph McGinnis,Simon C. Potter,Rathi Ravindrarajan,Pamela Whittaker,David Withers,David Bentley,David Bentley,Christopher J. Groves,Audrey Duncanson,Willem H. Ouwehand,Willem H. Ouwehand,James P. Boorman,James P. Boorman,Barbera Cant,Jennifer Jolley,Alexandra S. Knight,Kerstin Koch,Niall C. Taylor,Nicholas A. Watkins,Nicholas A. Watkins,Thilo Winzer,Peter S. Braund,Richard J. Dixon,Massimo Mangino,Suzanne Stevens,Peter Donnely,Dan Davidson,Jonathan Marchini,I. C.A. Spencer,Niall Cardin,Teresa Ferreira,Joanne Pereira-Gale,Ingeleif B. Hallgrimsdottir,Bryan Howie,Zhan Su,Damjan Vukcevic,Doug Easton,Ursula Everson,Judith M. Hussey,Elizabeth Meech,Christopher Prowse,Graham R. Walters,Richard Jones,Susan M. Ring,Marcus Prembey,Marcus Prembey,Gerome Breen,David St Clair,Sian Ceasar,Katherine Gordon-Smith,Katherine Gordon-Smith,Lisa Jones,Lisa Jones,Elaine K. Green,Detelinea Grozeva,Marian L. Hamshere,Peter Holmans,Ian Jones,George Kirov,Valentina Moskovina,Ivan Nikolov,Michael Conlon O'Donovan,Michael John Owen,David A. Collier,Amanda Elkin,Anne Farmer,Richard Williamson,Peter McGruffin,Allan H. Young,I. Nicol Ferrier,Stephen G. Ball,Anthony J. Balmforth,Jennifer H. Barrett,D. Timothy Bishop,Mark M. Iles,Azhar Maqbool,Nadira Yuldasheva,Alistair S. Hall,Francesca Bredin,Mark Tremelling,Miles Parkes,Hazel E. Drummond,Charlie W. Lees,Elaine R. Nimmo,Jack Satsangi,Sheila A. Fisher,Cathryn M. Lewis,Clive M. Onnie,Nathalie J. Prescott,Christopher G. Mathew,Alastair Forbes,Jeremy D. Sanderson,Christopher Mathew,Jamie Barbour,M. Khalid Mohiuddin,Catherine E. Todhunter,John C. Mansfield,Tariq Ahmad,Fraser Cummings,Derek P. Jewell,Anne Barton,Ian N. Bruce,Hannah Donovan,Steve Eyre,Paul D. Gilbert,Samantha L. Hider,Anne Hinks,Sally John,Catherine Potter,Alan J. Silman,Deborah P M Symmons,Wendy Thomson,Jane Worthington,Timothy M. Frayling,Rachel M. Freathy,Hana Lango,John R. B. Perry,Michael N. Weedon,Andrew T. Hattersley,Beverley M. Shields,Graham A. Hitman,Mark Walker,Melanie J. Newport,Giorgio Sirugo,David J. Conway,Muminatou Jallow,Linda A. Bradbury,Jennifer L. Pointon,Matthew A. Brown,Matthew A. Brown,C Farrar,Paul Wordsworth,Jayne A. Franklyn,Joanne M. Heward,Matthew J. Simmonds,Stephen C.L. Cough,Sheila Seal,Michael R. Stratton,Nazneen Rahman,An Goris,Stephen Sawcer,Alastair Compston +362 more
TL;DR: In this paper, the association between systolic or diastolic blood pressure and common variants in eight regions near the CYP17A1 (P = 7 × 10(-24)), CYP1A2(P = 1 × 10-23), FGF5 (P=1 × 10 -21), SH2B3(P= 3 × 10−18), MTHFR(MTHFR), c10orf107(P), ZNF652(ZNF652), PLCD3 (P,P = 5 × 10 −9),
Journal ArticleDOI
Neural substrates of awakening probed with optogenetic control of hypocretin neurons
TL;DR: It is found that direct, selective, optogenetic photostimulation of Hcrt neurons increased the probability of transition to wakefulness from either slow wave sleep or rapid eye movement sleep.