F
Feng Zhang
Researcher at Fudan University
Publications - 2715
Citations - 225233
Feng Zhang is an academic researcher from Fudan University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 172, co-authored 1278 publications receiving 181865 citations. Previous affiliations of Feng Zhang include Cincinnati Children's Hospital Medical Center & Nanjing Medical University.
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Journal ArticleDOI
YTHDF1 promotes breast cancer progression by facilitating FOXM1 translation in an m6A-dependent manner
Hengyu Chen,Yuanhang Yu,Mingming Yang,Haohao Huang,Shenghui Ma,Jin Hu,Zihan Xi,Hui Guo,Guojie Yao,Liuqing Yang,Xiao-qing Huang,Feng Zhang,Guang Tan,Huangfu Wu,Wuping Zheng,Lei Li +15 more
TL;DR: Wang et al. as discussed by the authors used integrating bioinformatics analyses to screen clinical relevance and dysregulated m6A "reader" protein YTHDF1 from TCGA databases, which was further validated in a cohort of clinical specimens.
Orthogonal gene knockout and activation with a catalytically active Cas9 nuclease
James E. Dahlman,James E. Dahlman,Omar O. Abudayyeh,Julia Joung,Jonathan S. Gootenberg,Feng Zhang,Silvana Konermann +6 more
TL;DR: A CRISPR-based method that uses catalytically active Cas9 and distinct single guide (sgRNA) constructs to knock out and activate different genes in the same cell, without inducing double-stranded breaks is developed.
Journal ArticleDOI
A Survey of Genome Editing Activity for 16 Cas12a Orthologs.
TL;DR: The class 2 CRISPR-Cas endonuclease Cas12a (previously known as Cpf1) offers several advantages over Cas9, including the ability to process its own array and the requirement for just a single RNA guide, which makes it promising for many genome engineering applications.
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Bi-allelic mutations of DNAH10 cause primary male infertility with asthenoteratozoospermia in humans and mice.
Chaofeng Tu,Jiangshan Cong,Qianjun Zhang,Xiaojin He,Xiaojin He,Rui Zheng,Xiaoxuan Yang,Yang Gao,Yang Gao,Huan Wu,Huan Wu,Mingrong Lv,Mingrong Lv,Yayun Gu,Shuai Lu,Chunyu Liu,Shixiong Tian,Lanlan Meng,Weili Wang,Chen Tan,Hongchuan Nie,Dongyan Li,Huan Zhang,Fei Gong,Liang Hu,Guangxiu Lu,Wenming Xu,Ge Lin,Feng Zhang,Yunxia Cao,Yunxia Cao,Yue-Qiu Tan +31 more
TL;DR: Wang et al. as discussed by the authors performed whole-exome sequencing in a cohort of 643 Chinese MMAF-affected men and found that DNAH10 encodes an axonemal IDA heavy chain component that is predominantly expressed in the testes.
Journal ArticleDOI
The role of cancer stem cells in cancer metastasis: new perspective and progress.
TL;DR: In this review, a survey of recent advances in the role and mechanism of metastatic CSCs is surveyed.