F
Feng Zhang
Researcher at Fudan University
Publications - 2715
Citations - 225233
Feng Zhang is an academic researcher from Fudan University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 172, co-authored 1278 publications receiving 181865 citations. Previous affiliations of Feng Zhang include Cincinnati Children's Hospital Medical Center & Nanjing Medical University.
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Journal ArticleDOI
Improved expression of halorhodopsin for light-induced silencing of neuronal activity.
Shengli Zhao,Catarina Cunha,Catarina Cunha,Feng Zhang,Qun Liu,Bernd Gloss,Karl Deisseroth,George J Augustine,Guoping Feng +8 more
TL;DR: Transgenic mice that express halorhodopsin (NpHR), a light-driven chloride pump that can be used to silence neuronal activity via light are described, and the improved version of NpHR should serve as an excellent tool for neuronal silencing in vitro and in vivo.
Journal ArticleDOI
Autism-like behaviours and germline transmission in transgenic monkeys overexpressing MeCP2
Zhen Liu,Xiao Li,Jun-Tao Zhang,Yijun Cai,Tian-Lin Cheng,Cheng Cheng,Yan Wang,Chen-Chen Zhang,Yanhong Nie,Zhi-Fang Chen,Wen-Jie Bian,Ling Zhang,Jianqiu Xiao,Bin Lu,Yuefang Zhang,Xiao-Di Zhang,Xiao Sang,Jia-Jia Wu,Xiu Xu,Zhi-Qi Xiong,Feng Zhang,Xiang Yu,Neng Gong,Wenhao Zhou,Qiang Sun,Zilong Qiu +25 more
TL;DR: It is reported that lentivirus-based transgenic cynomolgus monkeys (Macaca fascicularis) expressing human MeCP2 in the brain exhibit autism-like behaviours and show germline transmission of the transgene, indicating the feasibility and reliability of using genetically engineered non-human primates to study brain disorders.
Journal ArticleDOI
High-resolution interrogation of functional elements in the noncoding genome
Neville E. Sanjana,Neville E. Sanjana,Jason Wright,Jason Wright,Kaijie Zheng,Kaijie Zheng,Ophir Shalem,Ophir Shalem,Pierre Fontanillas,Julia Joung,Julia Joung,Christine S. Cheng,Christine S. Cheng,Aviv Regev,Aviv Regev,Feng Zhang,Feng Zhang +16 more
TL;DR: A CRISPR screen using ~18,000 single guide RNAs targeting >700 kilobases surrounding the genes NF1, NF2, and CUL3, which are involved in BRAF inhibitor resistance in melanoma, finds that noncoding locations that modulate drug resistance also harbor predictive hallmarks ofnoncoding function.
Posted ContentDOI
Point-of-care testing for COVID-19 using SHERLOCK diagnostics
Julia Joung,Alim Ladha,Makoto Saito,Michael Segel,Robert Bruneau,Meei-Li W. Huang,Nam-Gyun Kim,Xu G. Yu,Xu G. Yu,Jonathan Z. Li,Jonathan Z. Li,Bruce D. Walker,Alexander L. Greninger,Alexander L. Greninger,Keith R. Jerome,Keith R. Jerome,Jonathan S. Gootenberg,Omar O. Abudayyeh,Feng Zhang +18 more
TL;DR: This simplified test, STOPCovid, provides sensitivity comparable to RT-qPCR-based SARS-CoV-2 tests and has a limit of detection of 100 copies of viral genome input in saliva or nasopharyngeal swabs per reaction.
Journal ArticleDOI
Orthogonal gene knockout and activation with a catalytically active Cas9 nuclease.
James E. Dahlman,James E. Dahlman,Omar O. Abudayyeh,Julia Joung,Jonathan S. Gootenberg,Feng Zhang,Silvana Konermann +6 more
TL;DR: In this paper, a CRISPR-based method that uses catalytically active Cas9 and distinct single guide (sgRNA) constructs to knock out and activate different genes in the same cell was developed.