Feng Zhang

TL;DR: It is shown that depletion of all microRNAs suppresses tumor angiogenesis, and deletion of regions in FIH1 3' untranslated regions (UTRs) that contain microRNA-binding sites are deleted, which derepressesFIH1 protein and represses hypoxia response, suggesting that micro RNAs promote tumor responses to hypoxIA andAngiogenesis by repressing FIH 1.

TL;DR: High-resolution crystal structures delineated the altered PAM recognition mechanisms of the AsCpf1 variants, providing a basis for the further engineering of CRISPR-Cp f1, revealing that the RVR and RR variants primarily recognize the PAM-complementary nucleotides via the substituted residues.

TL;DR: The findings demonstrate the importance of comprehensive high‐resolution variant analysis in the assessment of personally relevant SUDEP risk and suggest the combination of de novo single nucleotide polymorphisms and CNVs in the SCN1A and KCNA1 genes is suspected to be the principal risk factor for both epilepsy and premature death.

TL;DR: In this paper, weakly ferromagnetic iron oxide nanoparticles with narrow size distribution were prepared by a high-temperature hydrolysis reaction, and the magnetic nanoparticles can self-assemble into one-dimensional particle chains on substrates as well as in colloid dispersion through magnetic dipolar interaction without the help of an applied magnetic field.

TL;DR: In vivo investigation of low-temperature isotropic pyrolytic carbon (LTI carbon) cylinders, widely used to fabricate artificial heart valves, and titanium-oxide-coated LTI carbon cylinders with diameters of 5 mm and thicknesses of 0.5 mm showed that the amount of thrombus on the Titanium oxide films was much less than that formed on the surface of LTIcarbon alone.