F
Feng Zhang
Researcher at Fudan University
Publications - 2715
Citations - 225233
Feng Zhang is an academic researcher from Fudan University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 172, co-authored 1278 publications receiving 181865 citations. Previous affiliations of Feng Zhang include Cincinnati Children's Hospital Medical Center & Nanjing Medical University.
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Journal Article
BLISS is a versatile and quantitative method for genome-wide profiling of DNA double-strand breaks
Reza Mirzazadeh,Silvano Garnerone,Martin W. Schneider,Tomasz Kallas,Joaquin Custodio,Erik L. G. Wernersson,Magda Bienko,Nicola Crosetto,Winston X. Yan,David Scott,Yinqing Li,Linyi Gao,Yana Federova,Bernd Zetsche,Feng Zhang +14 more
Journal ArticleDOI
Multidimensional chemical control of CRISPR–Cas9
Basudeb Maji,Basudeb Maji,Basudeb Maji,Christopher L. Moore,Christopher L. Moore,Bernd Zetsche,Sara E. Volz,Feng Zhang,Matthew D. Shoulders,Matthew D. Shoulders,Amit Choudhary,Amit Choudhary,Amit Choudhary +12 more
TL;DR: In this paper, small-molecule-regulated protein degron domains are applied to both Cas9-mediated genome editing and transcriptional activities, which opens new avenues for systematic genome interrogation.
Journal ArticleDOI
Recent advances in the research of an endemic osteochondropathy in China: Kashin-Beck disease
TL;DR: Kashin-Beck disease (KBD) is an endemic chronic osteochondral disease, which has a high prevalence and morbidity in the Eastern Siberia of Russia, and in the broad diagonal, northern-east to southern-west belt in China and North Korea.
Journal ArticleDOI
Optical Pooled Screens in Human Cells.
David Feldman,David Feldman,Avtar Singh,Jonathan L. Schmid-Burgk,Rebecca J. Carlson,Rebecca J. Carlson,Anja Mezger,Anja Mezger,Anthony J. Garrity,Feng Zhang,Paul C. Blainey,Paul C. Blainey +11 more
TL;DR: A pooled approach for optical genetic screens in mammalian cells using targeted in situ sequencing to demultiplex a library of genetic perturbations following image-based phenotyping with pooled libraries is introduced.
Proceedings ArticleDOI
GLM-130B: An Open Bilingual Pre-trained Model
Aohan Zeng,Xiao Liu,Zhengxiao Du,Zihan Wang,Hanyu Lai,Ming Ding,Zhuoyi Yang,Yifan Xu,Wendi Zheng,Xiao Xia,Weng Lam Tam,Zixuan Ma,Yufei Xue,Jidong Zhai,Wenguang Chen,Feng Zhang,Yuxiao Dong,Jie Tang +17 more
TL;DR: An attempt to open-source a 100B-scale model at least as good as GPT-3 and unveil how models of such a scale can be successfully pre-trained, including its design choices, training strategies for both efficiency and stability, and engineering efforts is introduced.