Novel Common Genetic Susceptibility Loci for Colorectal Cancer
Stephanie L. Schmit,Christopher K. Edlund,Fredrick R. Schumacher,Jian Gong,Tabitha A. Harrison,Jeroen R. Huyghe,Chenxu Qu,Marilena Melas,David Van Den Berg,Hansong Wang,Stephanie Tring,Sarah J. Plummer,Demetrius Albanes,M. Henar Alonso,Christopher I. Amos,Kristen Anton,Aaron K. Aragaki,Volker Arndt,Elizabeth L. Barry,Sonja I. Berndt,Stéphane Bézieau,Stephanie A. Bien,Amanda Bloomer,Juergen Boehm,Marie-Christine Boutron-Ruault,Marie-Christine Boutron-Ruault,Hermann Brenner,Stefanie Brezina,Daniel D. Buchanan,Daniel D. Buchanan,Katja Butterbach,Bette J. Caan,Peter T. Campbell,Chris S. Carlson,Jose E. Castelao,Andrew T. Chan,Jenny Chang-Claude,Jenny Chang-Claude,Stephen J. Chanock,Iona Cheng,Ya Wen Cheng,Lee Soo Chin,James M. Church,Timothy R. Church,Gerhard A. Coetzee,Michelle Cotterchio,Marcia Cruz Correa,Keith R. Curtis,David Duggan,Douglas F. Easton,Dallas R. English,Edith J. M. Feskens,Rocky Fischer,Liesel M. FitzGerald,Liesel M. FitzGerald,Barbara K. Fortini,Lars G. Fritsche,Lars G. Fritsche,Charles S. Fuchs,Charles S. Fuchs,Manuela Gago-Dominguez,Manish Gala,Steven Gallinger,W. James Gauderman,Graham G. Giles,Graham G. Giles,Edward Giovannucci,Edward Giovannucci,Stephanie M. Gogarten,Clicerio Gonzalez-Villalpando,Elena M. Gonzalez-Villalpando,William M. Grady,Joel K. Greenson,Andrea Gsur,Marc J. Gunter,Christopher A. Haiman,Jochen Hampe,Sophia Harlid,John F. Harju,Richard B. Hayes,Philipp Hofer,Michael Hoffmeister,John L. Hopper,Shu Chen Huang,José María Huerta,Thomas J. Hudson,David J. Hunter,Gregory Idos,Motoki Iwasaki,Rebecca D. Jackson,Eric J. Jacobs,Sun Ha Jee,Mark A. Jenkins,Weihua Jia,Shuo Jiao,Amit Joshi,Laurence N. Kolonel,Suminori Kono,Charles Kooperberg,Vittorio Krogh,Tilman Kuehn,Sébastien Küry,Andrea Z. LaCroix,Cecelia A. Laurie,Flavio Lejbkowicz,Flavio Lejbkowicz,Mathieu Lemire,Heinz-Josef Lenz,David N. Levine,Christopher I. Li,Li Li,Wolfgang Lieb,Yi Lin,Noralane M. Lindor,Yun Ru Liu,Fotios Loupakis,Yingchang Lu,Frank Luh,Jing Ma,Christoph Mancao,Frank J. Manion,Sanford D. Markowitz,Vicente Martín,Koichi Matsuda,Koichi Matsuda,Keitaro Matsuo,Kevin McDonnell,Caroline McNeil,Roger L. Milne,Roger L. Milne,Antonio J. Molina,Bhramar Mukherjee,Neil Murphy,Polly A. Newcomb,Kenneth Offit,Hanane Omichessan,Hanane Omichessan,Domenico Palli,Jesus P. Paredes Cotoré,Julyann Pérez-Mayoral,Paul D.P. Pharoah,John D. Potter,Conghui Qu,Leon Raskin,Gad Rennert,Gad Rennert,Hedy S. Rennert,Bridget M. Riggs,Clemens Schafmayer,Robert E. Schoen,Thomas A. Sellers,Daniela Seminara,Gianluca Severi,Wei Shi,David Shibata,Xiao-Ou Shu,Erin M. Siegel,Martha L. Slattery,Melissa C. Southey,Zsofia K. Stadler,Zsofia K. Stadler,Mariana C. Stern,Sebastian Stintzing,Darin Taverna,Stephen N. Thibodeau,Duncan C. Thomas,Antonia Trichopoulou,Shoichiro Tsugane,Cornelia M. Ulrich,Fränzel J.B. van Duijnhoven,Bethany van Guelpan,Joseph Vijai,Jarmo Virtamo,Stephanie J. Weinstein,Emily White,Aung Ko Win,Alicja Wolk,Michael O. Woods,Anna H. Wu,Kana Wu,Yong-Bing Xiang,Yun Yen,Brent W. Zanke,Brent W. Zanke,Yi Xin Zeng,Ben Zhang,Niha Zubair,Sun-Seog Kweon,Jane C. Figueiredo,Jane C. Figueiredo,Wei Zheng,Loic Le Marchand,Annika Lindblom,Victor Moreno,Ulrike Peters,Graham Casey,Li Hsu,David V. Conti,Stephen B. Gruber +198 more
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This article identified 42 loci (P < 5x10−8) associated with risk of colorectal cancer (CRC) and expanded consortium efforts facilitating the discovery of these loci.Abstract:
Background: Previous genome-wide association studies (GWAS) have identified 42 loci (P < 5x10(-8)) associated with risk of colorectal cancer (CRC). Expanded consortium efforts facilitating the d ...read more
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A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33
Gloria M. Petersen,Laufey T. Amundadottir,Charles S. Fuchs,Peter Kraft,Rachael Z. Stolzenberg-Solomon,Kevin B. Jacobs,Kevin B. Jacobs,Alan A. Arslan,H. Bas Bueno-de-Mesquita,Steven Gallinger,Myron D. Gross,Kathy J. Helzlsouer,Elizabeth A. Holly,Eric J. Jacobs,Alison P. Klein,Andrea Z. LaCroix,Donghui Li,Margaret T. Mandelson,Sara H. Olson,Harvey A. Risch,Wei Zheng,Demetrius Albanes,William R. Bamlet,Christine D. Berg,Marie-Christine Boutron-Ruault,Julie E. Buring,Paige M. Bracci,Federico Canzian,Sandra Clipp,Michelle Cotterchio,Mariza de Andrade,Eric J. Duell,J. Michael Gaziano,J. Michael Gaziano,Edward Giovannucci,Michael Goggins,Göran Hallmans,Susan E. Hankinson,Manal Hassan,Barbara V. Howard,David J. Hunter,Amy K. Hutchinson,Amy K. Hutchinson,Mazda Jenab,Rudolf Kaaks,Charles Kooperberg,Vittorio Krogh,Robert C. Kurtz,Shannon M. Lynch,Robert R. McWilliams,Julie B. Mendelsohn,Dominique S. Michaud,Dominique S. Michaud,Hemang Parikh,Alpa V. Patel,Petra H.M. Peeters,Petra H.M. Peeters,Aleksandar Rajkovic,Elio Riboli,Laudina Rodríguez,Daniela Seminara,Xiao-Ou Shu,Gilles Thomas,Gilles Thomas,Anne Tjønneland,Geoffrey S. Tobias,Dimitrios Trichopoulos,Dimitrios Trichopoulos,Stephen K. Van Den Eeden,Jarmo Virtamo,Jean Wactawski-Wende,Zhaoming Wang,Zhaoming Wang,Brian M. Wolpin,Herbert Yu,Kai Yu,Anne Zeleniuch-Jacquotte,Joseph F. Fraumeni,Robert N. Hoover,Patricia Hartge,Stephen J. Chanock,Stephen J. Chanock,Stephen J. Chanock +82 more
TL;DR: This study has identified common susceptibility loci for pancreatic cancer that warrant follow-up studies and identified eight SNPs that map to three loci on chromosomes 13q22.1, 1q32.1 and 5p15.1 that are associated with multiple cancers.
Journal ArticleDOI
Discovery of common and rare genetic risk variants for colorectal cancer
Jeroen R. Huyghe,Stephanie A. Bien,Tabitha A. Harrison,Hyun Min Kang,Sai Chen,Stephanie L. Schmit,David V. Conti,Conghui Qu,Jihyoun Jeon,Christopher K. Edlund,Peyton Greenside,Michael Wainberg,Fredrick R. Schumacher,Joshua D. Smith,David M. Levine,Sarah C. Nelson,Nasa Sinnott-Armstrong,Demetrius Albanes,M. Henar Alonso,Kristin E. Anderson,Coral Arnau-Collell,Volker Arndt,Christina Bamia,Barbara L. Banbury,John A. Baron,Sonja I. Berndt,Stéphane Bézieau,D. Timothy Bishop,Juergen Boehm,Heiner Boeing,Hermann Brenner,Stefanie Brezina,Stephan Buch,Daniel D. Buchanan,Daniel D. Buchanan,Andrea N. Burnett-Hartman,Katja Butterbach,Bette J. Caan,Peter T. Campbell,Christopher S. Carlson,Christopher S. Carlson,Sergi Castellví-Bel,Andrew T. Chan,Andrew T. Chan,Jenny Chang-Claude,Jenny Chang-Claude,Stephen J. Chanock,Maria Dolores Chirlaque,Sang-Hee Cho,Charles M. Connolly,Amanda J. Cross,Katarina Cuk,Keith R. Curtis,Albert de la Chapelle,Kimberly F. Doheny,David Duggan,Douglas F. Easton,Sjoerd G. Elias,Faye Elliott,Dallas R. English,Dallas R. English,Edith J. M. Feskens,Jane C. Figueiredo,Jane C. Figueiredo,Rocky Fischer,Liesel M. FitzGerald,Liesel M. FitzGerald,David Forman,Manish Gala,Steven Gallinger,W. James Gauderman,Graham G. Giles,Graham G. Giles,Elizabeth M. Gillanders,Jian Gong,Phyllis J. Goodman,William M. Grady,John S. Grove,Andrea Gsur,Marc J. Gunter,Robert W. Haile,Jochen Hampe,Heather Hampel,Sophia Harlid,Richard B. Hayes,Philipp Hofer,Michael Hoffmeister,John L. Hopper,John L. Hopper,Wan-Ling Hsu,Wen Yi Huang,Thomas J. Hudson,David J. Hunter,David J. Hunter,Gemma Ibáñez-Sanz,Gregory Idos,Roxann G. Ingersoll,Rebecca D. Jackson,Eric J. Jacobs,Mark A. Jenkins,Amit Joshi,Corinne E. Joshu,Temitope O. Keku,Timothy J. Key,Hyeong Rok Kim,Emiko Kobayashi,Laurence N. Kolonel,Charles Kooperberg,Tilman Kühn,Sébastien Küry,Sun-Seog Kweon,Susanna C. Larsson,Cecelia A. Laurie,Loic Le Marchand,Suzanne M. Leal,Soo-Chin Lee,Flavio Lejbkowicz,Mathieu Lemire,Christopher I. Li,Li Li,Wolfgang Lieb,Yi Lin,Annika Lindblom,Noralane M. Lindor,Hua Ling,Tin Louie,Satu Männistö,Sanford D. Markowitz,Vicente Martín,Giovanna Masala,Caroline McNeil,Marilena Melas,Roger L. Milne,Roger L. Milne,Lorena Moreno,Neil Murphy,Robin Myte,Alessio Naccarati,Polly A. Newcomb,Polly A. Newcomb,Kenneth Offit,Kenneth Offit,Shuji Ogino,Shuji Ogino,N. Charlotte Onland-Moret,Barbara Pardini,Patrick S. Parfrey,Rachel Pearlman,Vittorio Perduca,Vittorio Perduca,Paul D.P. Pharoah,Mila Pinchev,Elizabeth A. Platz,Ross L. Prentice,Elizabeth W. Pugh,Leon Raskin,Gad Rennert,Gad Rennert,Hedy S. Rennert,Hedy S. Rennert,Elio Riboli,Miguel Rodríguez-Barranco,Jane Romm,Lori C. Sakoda,Lori C. Sakoda,Clemens Schafmayer,Robert E. Schoen,Daniela Seminara,Mitul Shah,Tameka Shelford,Min-Ho Shin,Katerina Shulman,Sabina Sieri,Martha L. Slattery,Melissa C. Southey,Zsofia K. Stadler,Christa Stegmaier,Yu Ru Su,Catherine M. Tangen,Stephen N. Thibodeau,Duncan C. Thomas,Sushma S. Thomas,Amanda E. Toland,Antonia Trichopoulou,Cornelia M. Ulrich,David Van Den Berg,Fränzel J.B. Van Duijnhoven,Bethany Van Guelpen,Henk J. van Kranen,Joseph Vijai,Kala Visvanathan,Pavel Vodicka,Pavel Vodicka,Ludmila Vodickova,Ludmila Vodickova,Veronika Vymetalkova,Veronika Vymetalkova,Korbinian Weigl,Korbinian Weigl,Stephanie J. Weinstein,Emily White,Aung Ko Win,Aung Ko Win,C. Roland Wolf,Alicja Wolk,Alicja Wolk,Michael O. Woods,Anna H. Wu,Syed H.E. Zaidi,Brent W. Zanke,Qing Zhang,Wei Zheng,Peter C. Scacheri,John D. Potter,Michael C. Bassik,Anshul Kundaje,Graham Casey,Victor Moreno,Gonçalo R. Abecasis,Deborah A. Nickerson,Stephen B. Gruber,Li Hsu,Li Hsu,Ulrike Peters,Ulrike Peters +224 more
TL;DR: Genome-wide association analyses based on whole-genome sequencing and imputation identify 40 new risk variants for colorectal cancer, including a strongly protective low-frequency variant at CHD1 and loci implicating signaling and immune function in disease etiology.
Journal ArticleDOI
Epidemiology and Mechanisms of the Increasing Incidence of Colon and Rectal Cancers in Young Adults
TL;DR: In contrast to the decreasing incidence of colorectal cancer (CRC) in older populations, the incidence has nearly doubled in younger adults since the early 1990s, and approximately 1 in 10 new diagnoses of CRC are now made in individuals 50 years or younger.
Journal ArticleDOI
The genetics of human ageing
TL;DR: Bringing together different strands of genetic research, including results from recent large-scale genome-wide association studies relevant to human ageing, the authors highlight how genetics can further the authors' understanding of the underlying mechanisms of ageing.
Journal ArticleDOI
Association analyses identify 31 new risk loci for colorectal cancer susceptibility
Philip J. Law,Maria Timofeeva,Ceres Fernandez-Rozadilla,Peter Broderick,James B. Studd,Juan Fernández-Tajes,Susan M. Farrington,Victoria Svinti,Claire Palles,Giulia Orlando,Amit Sud,Amy Holroyd,Steven Penegar,Evropi Theodoratou,Evropi Theodoratou,P G Vaughan-Shaw,Harry Campbell,Harry Campbell,Lina Zgaga,Lina Zgaga,Caroline Hayward,Archie Campbell,Sarah E. Harris,Ian J. Deary,John M. Starr,Laura Gatcombe,M Pinna,S Briggs,Lynn Martin,E Jaeger,Archana Sharma-Oates,James E. East,Simon J. Leedham,Roland Arnold,Elaine C. Johnstone,Han Wang,David J. Kerr,Rachel Kerr,Tim Maughan,Richard Kaplan,Nada Al-Tassan,Kimmo Palin,Ulrika A. Hänninen,Tatiana Cajuso,Tomas Tanskanen,Johanna Kondelin,Eevi Kaasinen,Sarin A-P.,Johan G. Eriksson,Harri Rissanen,Paul Knekt,Eero Pukkala,Pekka Jousilahti,Veikko Salomaa,Samuli Ripatti,Samuli Ripatti,Aarno Palotie,Aarno Palotie,Laura Renkonen-Sinisalo,Anna Lepistö,Jürgen Böhm,Mecklin J-P.,Daniel D. Buchanan,Win A-K.,John L. Hopper,Mark Jenkins,N. M. Lindor,Polly A. Newcomb,S. Gallinger,David Duggan,Graham Casey,Per Hoffmann,M. M. Nöthen,Jöckel K-H.,Doug Easton,Pharoah Pdp.,Julian Peto,Federico Canzian,Anthony J. Swerdlow,Rosalind A. Eeles,Zsofia Kote-Jarai,Keith W. Muir,Nora Pashayan,Andrea Harkin,Karen Allan,John McQueen,James Paul,Timothy Iveson,Mark P Saunders,Katja Butterbach,Jenny Chang-Claude,Michael Hoffmeister,H Brenner,Iva Kirac,Petar Matošević,Philipp Hofer,Stefanie Brezina,Andrea Gsur,Jeremy Peter Cheadle,Lauri A. Aaltonen,Ian Tomlinson,Richard S. Houlston,Malcolm G. Dunlop +102 more
TL;DR: In this article, the authors reported a genome-wide association analysis of 34,627 colorectal cancer cases and 71,379 controls of European ancestry that identifies SNPs at 31 new CRC risk loci.
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Environmental and Heritable Factors in the Causation of Cancer — Analyses of Cohorts of Twins from Sweden, Denmark, and Finland
Paul Lichtenstein,Niels V. Holm,Pia K. Verkasalo,Anastasia Iliadou,Jaakko Kaprio,Jaakko Kaprio,Markku Koskenvuo,Markku Koskenvuo,Eero Pukkala,Axel Skytthe,Kari Hemminki +10 more
TL;DR: Inherited genetic factors make a minor contribution to susceptibility to most types of neoplasms, which indicates that the environment has the principal role in causing sporadic cancer.
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The ENCODE (ENCyclopedia of DNA elements) Project
Elise A. Feingold,Peter J. Good,Mark S. Guyer,S. Kamholz,L. Liefer,Kris A. Wetterstrand,Francis S. Collins,Thomas R. Gingeras,Dione Kampa,E. A. Sekinger,Jill Cheng,H. Hirsch,Srinka Ghosh,Zhou Zhu,Sandeep Patel,Antonio Piccolboni,A. Yang,Hari Tammana,Stefan Bekiranov,Philipp Kapranov,Rhonda Harrison,George M. Church,Kevin Struhl,Bing Ren,Tae Hoon Kim,Leah O. Barrera,Chunxu Qu,S. van Calcar,R. Luna,C. K. Glass,M. G. Rosenfeld,Roderic Guigó,Stylianos E. Antonarakis,Ewan Birney,Michael R. Brent,Lior Pachter,Alexandre Reymond,Emmanouil T. Dermitzakis,Colin N. Dewey,Damian Keefe,F. Denoeud,Julien Lagarde,Jennifer L. Ashurst,Tim Hubbard,Jan-Jaap Wesselink,Robert Castelo,Eduardo Eyras,Richard M. Myers,Arend Sidow,Serafim Batzoglou,Nathan D. Trinklein,Sara J. Hartman,Shelley Force Aldred,Elizabeth Anton,Diane I. Schroeder,S. S. Marticke,Long H. Nguyen,Jeremy Schmutz,Jane Grimwood,Mark Dickson,Gregory M. Cooper,Eric A. Stone,George Asimenos,Michael Brudno,Anindya Dutta,Neerja Karnani,Christopher M. Taylor,H. K. Kim,Gabriel Robins,George Stamatoyannopoulos,John A. Stamatoyannopoulos,Michael O. Dorschner,Peter J. Sabo,Michael Hawrylycz,Richard Humbert,James C. Wallace,Min-Feng Yu,Patrick A. Navas,M. McArthur,William Stafford Noble,Ian Dunham,Christof Koch,Robert M. Andrews,Gayle K. Clelland,Sarah Wilcox,Joanna C. Fowler,Keith D. James,P. Groth,Oliver M. Dovey,Peter D. Ellis,Vicki L. Wraight,Andrew J. Mungall,Pawandeep Dhami,Heike Fiegler,Cordelia Langford,Nigel P. Carter,David Vetrie,Michael Snyder,Ghia Euskirchen,Alexander E. Urban,Ugrappa Nagalakshmi,John L. Rinn,George V. Popescu,Paul Bertone,Stephen Hartman,Joel Rozowsky,Olof Emanuelsson,Thomas Royce,Sambath Chung,Mark Gerstein,Zheng Lian,Jane B. Lian,Y. Nakayama,Sherman M. Weissman,Viktor Stolc,W. Tongprasit,H. Sethi,Steven J.M. Jones,Marco A. Marra,H. Shin,Jacquie Schein,Michele Clamp,Kerstin Lindblad-Toh,Jean L. Chang,David B. Jaffe,Michael Kamal,Eric S. Lander,Tarjei S. Mikkelsen,Jade P. Vinson,Michael C. Zody,P. J. De Jong,Kazutoyo Osoegawa,Mikhail Nefedov,Baoli Zhu,Andreas D. Baxevanis,Tyra G. Wolfsberg,Gregory E. Crawford,James R R Whittle,Ingeborg Holt,T. J. Vasicek,D. Zhou,Shu-Jin Luo,Eric D. Green,Gerry Bouffard,Elliott H. Margulies,Matthew E. Portnoy,Nancy F. Hansen,Pamela J. Thomas,Jenny McDowell,Baishali Maskeri,Alice C. Young,Jacquelyn R. Idol,Robert W. Blakesley,Greg Schuler,Webb Miller,Ross C. Hardison,Laura Elnitski,Prachi Shah,Steven L. Salzberg,Mihaela Pertea,William H. Majoros,David Haussler,Daryl J. Thomas,Kate R. Rosenbloom,Hiram Clawson,Adam Siepel,W. J. Kent,Zhiping Weng,S. Jin,Anason S. Halees,H. Burden,Ulas Karaoz,Yutao Fu,Yong Yu,C. Ding,Charles R. Cantor,Robert E. Kingston,Jonathan H. Dennis,Roland Green,Michael A. Singer,Todd Richmond,J. E. Norton,Peggy J. Farnham,Matthew J. Oberley,D. R. Inman,M. R. McCormick,H. Kim,C. L. Middle,Michael C. Pirrung,Xiang-Dong Fu,Y. S. Kwon,Z. Ye,Job Dekker,Tomoko M. Tabuchi,Nele Gheldof,Josée Dostie,S. C. Harvey +196 more
TL;DR: The ENCyclopedia Of DNA Elements (ENCODE) Project is organized as an international consortium of computational and laboratory-based scientists working to develop and apply high-throughput approaches for detecting all sequence elements that confer biological function.
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The NIH Roadmap Epigenomics Mapping Consortium
Bradley E. Bernstein,John A. Stamatoyannopoulos,Joseph F. Costello,Bing Ren,Aleksandar Milosavljevic,Alexander Meissner,Manolis Kellis,Marco A. Marra,Arthur L. Beaudet,Joseph R. Ecker,Peggy J. Farnham,Martin Hirst,Eric S. Lander,Tarjei S. Mikkelsen,James A. Thomson +14 more
TL;DR: The NIH Roadmap Epigenomics Mapping Consortium aims to produce a public resource of epigenomic maps for stem cells and primary ex vivo tissues selected to represent the normal counterparts of tissues and organ systems frequently involved in human disease.
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Genome-wide association study of prostate cancer identifies a second risk locus at 8q24
Meredith Yeager,Nick Orr,Richard B. Hayes,Kevin B. Jacobs,Peter Kraft,Sholom Wacholder,Mark J Minichiello,Paul Fearnhead,Kai Yu,Nilanjan Chatterjee,Zhaoming Wang,Zhaoming Wang,Robert W Welch,Robert W Welch,Brian Staats,Brian Staats,Eugenia E. Calle,Heather Spencer Feigelson,Michael J. Thun,Carmen Rodriguez,Demetrius Albanes,Jarmo Virtamo,Stephanie J. Weinstein,Fredrick R. Schumacher,Edward Giovannucci,Walter C. Willett,Geraldine Cancel-Tassin,Olivier Cussenot,Antoine Valeri,Gerald L. Andriole,Edward P. Gelmann,Margaret A. Tucker,Daniela S. Gerhard,Joseph F. Fraumeni,Robert N. Hoover,David J. Hunter,David J. Hunter,Stephen J. Chanock,Gilles Thomas +38 more
TL;DR: Observations indicate the presence of at least two independent loci within 8q24 that contribute to prostate cancer in men of European ancestry, and it is estimated that the population attributable risk of the new locus, marked by rs6983267, is higher than the locus marked byrs1447295.
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Discovery of common and rare genetic risk variants for colorectal cancer
Jeroen R. Huyghe,Stephanie A. Bien,Tabitha A. Harrison,Hyun Min Kang,Sai Chen,Stephanie L. Schmit,David V. Conti,Conghui Qu,Jihyoun Jeon,Christopher K. Edlund,Peyton Greenside,Michael Wainberg,Fredrick R. Schumacher,Joshua D. Smith,David M. Levine,Sarah C. Nelson,Nasa Sinnott-Armstrong,Demetrius Albanes,M. Henar Alonso,Kristin E. Anderson,Coral Arnau-Collell,Volker Arndt,Christina Bamia,Barbara L. Banbury,John A. Baron,Sonja I. Berndt,Stéphane Bézieau,D. Timothy Bishop,Juergen Boehm,Heiner Boeing,Hermann Brenner,Stefanie Brezina,Stephan Buch,Daniel D. Buchanan,Daniel D. Buchanan,Andrea N. Burnett-Hartman,Katja Butterbach,Bette J. Caan,Peter T. Campbell,Christopher S. Carlson,Christopher S. Carlson,Sergi Castellví-Bel,Andrew T. Chan,Andrew T. Chan,Jenny Chang-Claude,Jenny Chang-Claude,Stephen J. Chanock,Maria Dolores Chirlaque,Sang-Hee Cho,Charles M. Connolly,Amanda J. Cross,Katarina Cuk,Keith R. Curtis,Albert de la Chapelle,Kimberly F. Doheny,David Duggan,Douglas F. Easton,Sjoerd G. Elias,Faye Elliott,Dallas R. English,Dallas R. English,Edith J. M. Feskens,Jane C. Figueiredo,Jane C. Figueiredo,Rocky Fischer,Liesel M. FitzGerald,Liesel M. FitzGerald,David Forman,Manish Gala,Steven Gallinger,W. James Gauderman,Graham G. Giles,Graham G. Giles,Elizabeth M. Gillanders,Jian Gong,Phyllis J. Goodman,William M. Grady,John S. Grove,Andrea Gsur,Marc J. Gunter,Robert W. Haile,Jochen Hampe,Heather Hampel,Sophia Harlid,Richard B. Hayes,Philipp Hofer,Michael Hoffmeister,John L. Hopper,John L. Hopper,Wan-Ling Hsu,Wen Yi Huang,Thomas J. Hudson,David J. Hunter,David J. Hunter,Gemma Ibáñez-Sanz,Gregory Idos,Roxann G. Ingersoll,Rebecca D. Jackson,Eric J. Jacobs,Mark A. Jenkins,Amit Joshi,Corinne E. Joshu,Temitope O. Keku,Timothy J. Key,Hyeong Rok Kim,Emiko Kobayashi,Laurence N. Kolonel,Charles Kooperberg,Tilman Kühn,Sébastien Küry,Sun-Seog Kweon,Susanna C. Larsson,Cecelia A. Laurie,Loic Le Marchand,Suzanne M. Leal,Soo-Chin Lee,Flavio Lejbkowicz,Mathieu Lemire,Christopher I. Li,Li Li,Wolfgang Lieb,Yi Lin,Annika Lindblom,Noralane M. Lindor,Hua Ling,Tin Louie,Satu Männistö,Sanford D. Markowitz,Vicente Martín,Giovanna Masala,Caroline McNeil,Marilena Melas,Roger L. Milne,Roger L. Milne,Lorena Moreno,Neil Murphy,Robin Myte,Alessio Naccarati,Polly A. Newcomb,Polly A. Newcomb,Kenneth Offit,Kenneth Offit,Shuji Ogino,Shuji Ogino,N. Charlotte Onland-Moret,Barbara Pardini,Patrick S. Parfrey,Rachel Pearlman,Vittorio Perduca,Vittorio Perduca,Paul D.P. Pharoah,Mila Pinchev,Elizabeth A. Platz,Ross L. Prentice,Elizabeth W. Pugh,Leon Raskin,Gad Rennert,Gad Rennert,Hedy S. Rennert,Hedy S. Rennert,Elio Riboli,Miguel Rodríguez-Barranco,Jane Romm,Lori C. Sakoda,Lori C. Sakoda,Clemens Schafmayer,Robert E. Schoen,Daniela Seminara,Mitul Shah,Tameka Shelford,Min-Ho Shin,Katerina Shulman,Sabina Sieri,Martha L. Slattery,Melissa C. Southey,Zsofia K. Stadler,Christa Stegmaier,Yu Ru Su,Catherine M. Tangen,Stephen N. Thibodeau,Duncan C. Thomas,Sushma S. Thomas,Amanda E. Toland,Antonia Trichopoulou,Cornelia M. Ulrich,David Van Den Berg,Fränzel J.B. Van Duijnhoven,Bethany Van Guelpen,Henk J. van Kranen,Joseph Vijai,Kala Visvanathan,Pavel Vodicka,Pavel Vodicka,Ludmila Vodickova,Ludmila Vodickova,Veronika Vymetalkova,Veronika Vymetalkova,Korbinian Weigl,Korbinian Weigl,Stephanie J. Weinstein,Emily White,Aung Ko Win,Aung Ko Win,C. Roland Wolf,Alicja Wolk,Alicja Wolk,Michael O. Woods,Anna H. Wu,Syed H.E. Zaidi,Brent W. Zanke,Qing Zhang,Wei Zheng,Peter C. Scacheri,John D. Potter,Michael C. Bassik,Anshul Kundaje,Graham Casey,Victor Moreno,Gonçalo R. Abecasis,Deborah A. Nickerson,Stephen B. Gruber,Li Hsu,Li Hsu,Ulrike Peters,Ulrike Peters +224 more
Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis
Ulrike Peters,Ulrike Peters,Shuo Jiao,Fredrick R. Schumacher,Carolyn M. Hutter,Carolyn M. Hutter,Aaron K. Aragaki,John A. Baron,Sonja I. Berndt,Stéphane Bézieau,Hermann Brenner,Katja Butterbach,Bette J. Caan,Peter T. Campbell,Christopher S. Carlson,Christopher S. Carlson,Graham Casey,Andrew T. Chan,Jenny Chang-Claude,Stephen J. Chanock,Lin Chen,Gerhard A. Coetzee,Simon G. Coetzee,David V. Conti,Keith R. Curtis,David Duggan,Todd L. Edwards,Charles S. Fuchs,Steven Gallinger,Edward Giovannucci,Stephanie M. Gogarten,Stephen B. Gruber,Robert W. Haile,Tabitha A. Harrison,Richard B. Hayes,Brian E. Henderson,Michael Hoffmeister,John L. Hopper,Thomas J. Hudson,Thomas J. Hudson,David J. Hunter,Rebecca D. Jackson,Sun Ha Jee,Mark A. Jenkins,Wei Hua Jia,Laurence N. Kolonel,Charles Kooperberg,Sébastien Küry,Andrea Z. LaCroix,Cathy C. Laurie,Cecelia A. Laurie,Loic Le Marchand,Mathieu Lemire,David K. Levine,Noralane M. Lindor,Yan Liu,Jing Ma,Karen W. Makar,Keitaro Matsuo,Polly A. Newcomb,Polly A. Newcomb,John D. Potter,John D. Potter,Ross L. Prentice,Conghui Qu,Thomas E. Rohan,Stephanie A. Rosse,Stephanie A. Rosse,Robert E. Schoen,Daniela Seminara,Martha J. Shrubsole,Xiao-Ou Shu,Martha L. Slattery,Darin Taverna,Stephen N. Thibodeau,Cornelia M. Ulrich,Emily White,Emily White,Yong-Bing Xiang,Brent W. Zanke,Yi Xin Zeng,Ben Zhang,Wei Zheng,Li Hsu +83 more
A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3
Ian Tomlinson,Emily L. Webb,Luis G. Carvajal-Carmona,Peter Broderick,Kimberley Howarth,Alan M. Pittman,Sarah L. Spain,Steven J. Lubbe,Axel Walther,Kate Sullivan,Emma Jaeger,Sarah Fielding,Andrew Rowan,Jayaram Vijayakrishnan,Enric Domingo,Ian Chandler,Zoe Kemp,Mobshra Qureshi,Susan M. Farrington,Albert Tenesa,James G. D. Prendergast,Rebecca A. Barnetson,Steven Penegar,Ella Barclay,Wendy Wood,Lynn Martin,Lynn Martin,Lynn Martin,Maggie Gorman,Huw Thomas,Julian Peto,D. Timothy Bishop,Richard Gray,Eamonn R. Maher,Anneke Lucassen,David J. Kerr,D. Gareth Evans,Clemens Schafmayer,Stephan Buch,Henry Völzke,Jochen Hampe,Stefan Schreiber,Ulrich John,Thibaud Koessler,Paul D.P. Pharoah,Tom van Wezel,Hans Morreau,Juul T. Wijnen,John L. Hopper,Melissa C. Southey,Graham G. Giles,Graham G. Giles,Gianluca Severi,Sergi Castellví-Bel,Clara Ruiz-Ponte,Angel Carracedo,Antoni Castells,Asta Försti,Asta Försti,Kari Hemminki,Kari Hemminki,Pavel Vodicka,Alessio Naccarati,Lara Lipton,Judy W. C. Ho,King Yip Cheng,Pak C. Sham,John M. Luk,José A. G. Agúndez,José M. Ladero,Miguel de la Hoya,Trinidad Caldés,Iina Niittymäki,Sari Tuupanen,Auli Karhu,Lauri A. Aaltonen,Jean-Baptiste Cazier,Harry Campbell,Malcolm G. Dunlop,Richard S. Houlston +79 more
Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer
Richard S. Houlston,Emily L. Webb,Peter Broderick,Alan M. Pittman,Maria Chiara Di Bernardo,Steven J. Lubbe,Ian Chandler,Jayaram Vijayakrishnan,Kate Sullivan,Steven Penegar,Luis G. Carvajal-Carmona,Kimberley Howarth,Emma Jaeger,Sarah L. Spain,Axel Walther,Ella Barclay,Lynn Martin,Maggie Gorman,Enric Domingo,Ana Teixeira,David J. Kerr,Jean-Baptiste Cazier,Iina Niittymäki,Sari Tuupanen,Auli Karhu,Lauri A. Aaltonen,Ian Tomlinson,Susan M. Farrington,Albert Tenesa,James Prendergast,Rebecca A. Barnetson,Roseanne Cetnarskyj,Mary Porteous,Paul D.P. Pharoah,Thibaud Koessler,Jochen Hampe,Stephan Buch,Clemens Schafmayer,Jürgen Tepel,Stefan Schreiber,Henry Völzke,Jenny Chang-Claude,Michael Hoffmeister,Hermann Brenner,Brent W. Zanke,Alexandre Montpetit,Thomas J. Hudson,Thomas J. Hudson,Thomas J. Hudson,Steven Gallinger,Steven Gallinger,Harry Campbell,Malcolm G. Dunlop +52 more