R
Rob Knight
Researcher at University of California, San Diego
Publications - 1188
Citations - 322479
Rob Knight is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Microbiome & Biology. The author has an hindex of 201, co-authored 1061 publications receiving 253207 citations. Previous affiliations of Rob Knight include Anschutz Medical Campus & University of Sydney.
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Journal ArticleDOI
Rapidly denoising pyrosequencing amplicon reads by exploiting rank-abundance distributions.
Jens Reeder,Rob Knight +1 more
TL;DR: A fast method for denoising pyrosequencing for community 16S rRNA analysis is developed and a 2–4 fold reduction in the number of observed OTUs is observed comparing denoised with non-denoised data.
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Gut bacteria from multiple sclerosis patients modulate human T cells and exacerbate symptoms in mouse models.
Egle Cekanaviciute,Bryan B. Yoo,Tessel F. Runia,Justine W. Debelius,Sneha Singh,Charlotte A. Nelson,Rachel Kanner,Yadira Bencosme,Yun Kyung Lee,Stephen L. Hauser,Elizabeth Crabtree-Hartman,Ilana Katz Sand,Mar Gacias,Yungjiao Zhu,Patrizia Casaccia,Patrizia Casaccia,Bruce A.C. Cree,Rob Knight,Sarkis K. Mazmanian,Sergio E. Baranzini +19 more
TL;DR: The results expand the knowledge of the microbial regulation of immunity and may provide a basis for the development of microbiome-based therapeutics in autoimmune diseases.
Journal ArticleDOI
Microbiota Regulate Intestinal Absorption and Metabolism of Fatty Acids in the Zebrafish
Ivana Semova,Juliana D. Carten,Jesse Stombaugh,Lantz C. Mackey,Rob Knight,Steven A. Farber,John F. Rawls +6 more
TL;DR: In vivo imaging of fluorescent fatty acid analogs delivered to gnotobiotic zebrafish hosts reveals that microbiota stimulate FA uptake and lipid droplet formation in the intestinal epithelium and liver, providing mechanistic insight into how microbiota-diet interactions regulate host energy balance.
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Long-term pamidronate treatment of advanced multiple myeloma patients reduces skeletal events. Myeloma Aredia Study Group.
James R. Berenson,Alan Lichtenstein,Lester Porter,Meletios A. Dimopoulos,Roldolfo Bordoni,Sebastian George,Alan Lipton,Alan Keller,O. F. Ballester,Michael J. Kovacs,Hillary Blacklock,Richard Bryan Bell,Joseph F. Simeone,Dirk J. Reitsma,Maika Heffernan,John J. Seaman,Rob Knight +16 more
TL;DR: Long-term monthly infusions of pamidronate as an adjunct to chemotherapy are superior to chemotherapy alone in reducing skeletal events in stage III multiple myeloma patients, and may improve the survival of patients on salvage therapy.
Journal ArticleDOI
Identifying Genetic Determinants Needed to Establish a Human Gut Symbiont in Its Habitat
Andrew L. Goodman,Nathan P. McNulty,Yue Zhao,Douglas D. Leip,Robi D. Mitra,Catherine A. Lozupone,Catherine A. Lozupone,Rob Knight,Jeffrey I. Gordon +8 more
TL;DR: This work used massively parallel sequencing to monitor the relative abundance of tens of thousands of transposon mutants of a saccharolytic human gut bacterium, Bacteroides thetaiotaomicron, as they established themselves in wild-type and immunodeficient gnotobiotic mice, in the presence or absence of other human gut commensals.