R
Rob Knight
Researcher at University of California, San Diego
Publications - 1188
Citations - 322479
Rob Knight is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Microbiome & Biology. The author has an hindex of 201, co-authored 1061 publications receiving 253207 citations. Previous affiliations of Rob Knight include Anschutz Medical Campus & University of Sydney.
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Metagenomics-Based, Strain-Level Analysis of Escherichia coli From a Time-Series of Microbiome Samples From a Crohn's Disease Patient.
Xin Fang,Jonathan M. Monk,Sergey Nurk,Margarita Akseshina,Qiyun Zhu,Christopher Gemmell,Connor Gianetto-Hill,Nelly Leung,Richard Szubin,Jon G. Sanders,Paul L. Beck,Weizhong Li,William J. Sandborn,Scott D. Gray-Owen,Rob Knight,Emma Allen-Vercoe,Bernhard O. Palsson,Larry Smarr +17 more
TL;DR: In conclusion, inflammation status (assessed by the blood C-reactive protein and stool calprotectin) is likely correlated with the abundance of a subgroup of E. coli strains with specific traits, and strain-level time-series analysis of dominant E.ccoli strains in a CD patient is highly informative, and motivates a study of a larger cohort of IBD patients.
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Gut microbiome in Schizophrenia: Altered functional pathways related to immune modulation and atherosclerotic risk.
Tanya T. Nguyen,Tomasz Kosciolek,Rebecca Daly,Yoshiki Vázquez-Baeza,Austin D. Swafford,Rob Knight,Dilip V. Jeste +6 more
TL;DR: Functional pathways related to trimethylamine-N-oxide reductase and Kdo2-lipid A biosynthesis were altered in schizophrenia and were associated with inflammatory cytokines and risk for coronary heart disease in schizophrenia.
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Challenges in the construction of knowledge bases for human microbiome-disease associations.
Varsha D. Badal,Dustin Wright,Yannis Katsis,Ho-Cheol Kim,Austin D. Swafford,Rob Knight,Chun-Nan Hsu +6 more
TL;DR: The existing tools and development efforts to capture portions of the information needed to construct a KB of all known human microbiome-disease associations are surveyed and the need for additional innovations in natural language processing, text mining, taxonomic representations, and field-wide vocabulary standardization in human microbiome research is highlighted.
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redbiom: a Rapid Sample Discovery and Feature Characterization System
Daniel McDonald,Benjamin D. Kaehler,Antonio Gonzalez,Jeff DeReus,Gail Ackermann,Clarisse Marotz,Gavin A. Huttley,Rob Knight +7 more
TL;DR: Redbiom is introduced, a microbiome caching layer, which allows users to rapidly query samples that contain a given feature, retrieve sample data and metadata, and search for samples that match specified metadata values or ranges using an in-memory NoSQL database called Redis.
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Digitizing mass spectrometry data to explore the chemical diversity and distribution of marine cyanobacteria and algae.
Tal Luzzatto-Knaan,Neha Garg,Mingxun Wang,Evgenia Glukhov,Yao Peng,Gail Ackermann,Amnon Amir,Brendan M. Duggan,Sergey Ryazanov,Lena Gerwick,Rob Knight,Theodore Alexandrov,Nuno Bandeira,Nuno Bandeira,William H. Gerwick,William H. Gerwick,Pieter C. Dorrestein,Pieter C. Dorrestein +17 more
TL;DR: Untargeted mass spectrometry approaches were applied to capture the chemical space and dispersal patterns of metabolites from an in-house library of marine cyanobacterial and algal collections, supporting the hypothesis that marine Cyanobacteria and algae possess distinctive metabolomes.