G
Gord Glendon
Researcher at University of Toronto
Publications - 74
Citations - 6600
Gord Glendon is an academic researcher from University of Toronto. The author has contributed to research in topics: Breast cancer & Single-nucleotide polymorphism. The author has an hindex of 34, co-authored 66 publications receiving 5587 citations. Previous affiliations of Gord Glendon include Cancer Care Ontario & Mount Sinai Hospital, Toronto.
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Journal ArticleDOI
Association Between BRCA1 and BRCA2 Mutations and Survival in Women with Invasive Epithelial Ovarian Cancer
Kelly L. Bolton,Kelly L. Bolton,Georgia Chenevix-Trench,Cindy Goh,Siegal Sadetzki,Susan J. Ramus,Beth Y. Karlan,Diether Lambrechts,Evelyn Despierre,Daniel Barrowdale,Lesley McGuffog,Sue Healey,Douglas F. Easton,Olga M. Sinilnikova,Javier Benitez,María Jesús Gómez García,Susan L. Neuhausen,Mitchell H. Gail,Patricia Hartge,Susan Peock,Debra Frost,D. Gareth Evans,Rosalind A. Eeles,Andrew K. Godwin,Mary B. Daly,Ava Kwong,Ava Kwong,Edmond S. K. Ma,Conxi Lázaro,Ignacio Blanco,Marco Montagna,Emma D'Andrea,Maria Ornella Nicoletto,Sharon E. Johnatty,Susanne K. Kjaer,Allan Jensen,Estrid Høgdall,Ellen L. Goode,Brooke L. Fridley,Jennifer T. Loud,Mark H. Greene,Phuong L. Mai,Angela Chetrit,Flora Lubin,Galit Hirsh-Yechezkel,Gord Glendon,Irene L. Andrulis,Irene L. Andrulis,Amanda E. Toland,Leigha Senter,Martin Gore,Charlie Gourley,Caroline O. Michie,Honglin Song,Jonathan Tyrer,Alice S. Whittemore,Valerie McGuire,Weiva Sieh,Ulf Kristoffersson,Håkan Olsson,Åke Borg,Douglas A. Levine,Linda Steele,Mary S. Beattie,Salina Chan,Robert L. Nussbaum,Kirsten B. Moysich,Jenny Gross,Ilana Cass,Christine Walsh,Andrew J. Li,R.S. Leuchter,Ora Gordon,Montserrat Garcia-Closas,Simon A. Gayther,Stephen J. Chanock,Antonis C. Antoniou,Paul D.P. Pharoah +77 more
TL;DR: Among patients with invasive EOC, having a germline mutation in BRCA1 or BRC a2 was associated with improved 5-year overall survival and BRCa2 carriers had the best prognosis.
Journal ArticleDOI
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer
Stig E. Bojesen,Stig E. Bojesen,Karen A. Pooley,Sharon E. Johnatty,Jonathan Beesley,Kyriaki Michailidou,Jonathan Tyrer,Stacey L. Edwards,Hilda A. Pickett,Hilda A. Pickett,Howard C. Shen,Chanel E. Smart,Kristine M. Hillman,Phuong L. Mai,Kate Lawrenson,Michael D. Stutz,Michael D. Stutz,Yi Lu,Rod Karevan,Nicholas T. Woods,Rebecca L. Johnston,Juliet D. French,Xiaoqing Chen,Maren Weischer,Sune F. Nielsen,Melanie Maranian,Maya Ghoussaini,Shahana Ahmed,Caroline Baynes,Manjeet K. Bolla,Qin Wang,Joe Dennis,Lesley McGuffog,Daniel Barrowdale,Andrew Lee,Sue Healey,Michael Lush,Daniel C. Tessier,Daniel Vincent,Françis Bacot,Ignace Vergote,Sandrina Lambrechts,Evelyn Despierre,Harvey A. Risch,Anna González-Neira,Mary Anne Rossing,Mary Anne Rossing,Guillermo Pita,Jennifer A. Doherty,Nuria Álvarez,Melissa C. Larson,Brooke L. Fridley,Nils Schoof,Jenny Chang-Claude,Mine S. Cicek,Julian Peto,Kimberly R. Kalli,Annegien Broeks,Sebastian M. Armasu,Marjanka K. Schmidt,Linde M. Braaf,Boris Winterhoff,Heli Nevanlinna,Gottfried E. Konecny,Diether Lambrechts,L. Rogmann,Pascal Guénel,Attila Teoman,Roger L. Milne,Joaquin J. Garcia,Angela Cox,Vijayalakshmi Shridhar,Barbara Burwinkel,Frederik Marmé,Rebecca Hein,Rebecca Hein,Elinor J. Sawyer,Christopher A. Haiman,Shan Wang-Gohrke,Irene L. Andrulis,Kirsten B. Moysich,John L. Hopper,Kunle Odunsi,Annika Lindblom,Graham G. Giles,Graham G. Giles,Graham G. Giles,Hermann Brenner,Jacques Simard,Galina Lurie,Peter A. Fasching,Peter A. Fasching,Michael E. Carney,Paolo Radice,Lynne R. Wilkens,Anthony J. Swerdlow,Marc T. Goodman,Hiltrud Brauch,Hiltrud Brauch,Montserrat Garcia-Closas,Peter Hillemanns,Robert Winqvist,Matthias Dürst,Peter Devilee,Ingo B. Runnebaum,Anna Jakubowska,Jan Lubinski,Arto Mannermaa,Ralf Bützow,Natalia Bogdanova,Thilo Dörk,Liisa M. Pelttari,Wei Zheng,Arto Leminen,Hoda Anton-Culver,Clareann H. Bunker,Vessela N. Kristensen,Roberta B. Ness,Kenneth Muir,Kenneth Muir,Robert Edwards,Alfons Meindl,Florian Heitz,Keitaro Matsuo,Andreas du Bois,Anna H. Wu,Philipp Harter,Soo Hwang Teo,Ira Schwaab,Xiao-Ou Shu,William Blot,Satoyo Hosono,Daehee Kang,Toru Nakanishi,Mikael Hartman,Mikael Hartman,Yasushi Yatabe,Ute Hamann,Beth Y. Karlan,Suleeporn Sangrajrang,Susanne K. Kjaer,Valerie Gaborieau,Allan Jensen,Diana Eccles,Estrid Høgdall,Chen-Yang Shen,Chen-Yang Shen,Judith E. Brown,Yin Ling Woo,Mitul Shah,Mat Adenan Noor Azmi,Robert Luben,Siti Zawiah Omar,Kamila Czene,Robert A. Vierkant,Børge G. Nordestgaard,Henrik Flyger,Celine M. Vachon,Janet E. Olson,Xianshu Wang,Douglas A. Levine,Anja Rudolph,Rachel Palmieri Weber,Dieter Flesch-Janys,Edwin S. Iversen,Stefan Nickels,Joellen M. Schildkraut,Isabel dos Santos Silva,Daniel W. Cramer,Lorna Gibson,Kathryn L. Terry,Olivia Fletcher,Allison F. Vitonis,C. Ellen van der Schoot,Elizabeth M. Poole,Frans B. L. Hogervorst,Shelley S. Tworoger,Jianjun Liu,Elisa V. Bandera,Jingmei Li,Sara H. Olson,Keith Humphreys,Irene Orlow,Carl Blomqvist,Lorna Rodriguez-Rodriguez,Kristiina Aittomäki,Helga B. Salvesen,Taru A. Muranen,Elisabeth Wik,Barbara Brouwers,Camilla Krakstad,Els Wauters,Mari K. Halle,Hans Wildiers,Lambertus A. Kiemeney,Claire Mulot,Katja K.H. Aben,Pierre Laurent-Puig,Anne M. van Altena,Thérèse Truong,Leon F.A.G. Massuger,Javier Benitez,Tanja Pejovic,Jose Ignacio Arias Perez,Maureen E. Hoatlin,M. Pilar Zamora,Linda S. Cook,Sabapathy P. Balasubramanian,Linda E. Kelemen,Andreas Schneeweiss,Nhu D. Le,Christof Sohn,Angela Brooks-Wilson,Angela Brooks-Wilson,Ian Tomlinson,Michael J. Kerin,Nicola Miller,Cezary Cybulski,Brian E. Henderson,Janusz Menkiszak,Fredrick R. Schumacher,Nicolas Wentzensen,Loic Le Marchand,Hannah P. Yang,Anna Marie Mulligan,Gord Glendon,Svend Aage Engelholm,Julia A. Knight,Claus Høgdall,Carmel Apicella,Martin Gore,Helen Tsimiklis,Honglin Song,Melissa C. Southey,Agnes Jager,Ans M Wvan Den Ouweland,Robert S. Brown,John W.M. Martens,James M. Flanagan,Mieke Kriege,James Paul,Sara Margolin,Nadeem Siddiqui,Gianluca Severi,Gianluca Severi,Alice S. Whittemore,Laura Baglietto,Laura Baglietto,Valerie McGuire,Christa Stegmaier,Weiva Sieh,Heiko Müller,Volker Arndt,Yu Tang Gao,Mark S. Goldberg,Gong Yang,Martine Dumont,John R. McLaughlin,Arndt Hartmann,Arif B. Ekici,Matthias W. Beckmann,Catherine M. Phelan,Michael P. Lux,Jenny Permuth-Wey,Bernard Peissel,Thomas A. Sellers,Filomena Ficarazzi,Monica Barile,Argyrios Ziogas,Alan Ashworth,Aleksandra Gentry-Maharaj,Michael Jones,Susan J. Ramus,Nick Orr,Usha Menon,Celeste Leigh Pearce,Thomas Brüning,Malcolm C. Pike,Malcolm C. Pike,Yon Ko,Jolanta Lissowska,Jonine D. Figueroa,Jolanta Kupryjanczyk,Stephen J. Chanock,Agnieszka Dansonka-Mieszkowska,Arja Jukkola-Vuorinen,Iwona K. Rzepecka,Katri Pylkäs,Mariusz Bidziński,Saila Kauppila,Antoinette Hollestelle,Caroline Seynaeve,Rob A. E. M. Tollenaar,Katarzyna Durda,Katarzyna Jaworska,Katarzyna Jaworska,Jaana M. Hartikainen,Veli-Matti Kosma,Vesa Kataja,Natalia Antonenkova,Jirong Long,Martha J. Shrubsole,Sandra Deming-Halverson,Artitaya Lophatananon,Artitaya Lophatananon,Pornthep Siriwanarangsan,Sarah Stewart-Brown,Nina Ditsch,Peter Lichtner,Rita K. Schmutzler,Hidemi Ito,Hiroji Iwata,Kazuo Tajima,Chiu-Chen Tseng,Daniel O. Stram,David Van Den Berg,Cheng Har Yip,M. Kamran Ikram,Yew Ching Teh,Hui Cai,Wei Lu,Lisa B. Signorello,Qiuyin Cai,Dong Young Noh,Keun-Young Yoo,Hui Miao,Philip Iau,Yik Ying Teo,James McKay,Charles L. Shapiro,Foluso O. Ademuyiwa,George Fountzilas,Chia-Ni Hsiung,Jyh Cherng Yu,Ming-Feng Hou,Catherine S. Healey,Craig Luccarini,Susan Peock,Dominique Stoppa-Lyonnet,Paolo Peterlongo,Timothy R. Rebbeck,Marion Piedmonte,Christian F. Singer,Eitan Friedman,Mads Thomassen,Kenneth Offit,Thomas Hansen,Susan L. Neuhausen,Csilla Szabo,Ignacio Blanco,Judy Garber,Steven A. Narod,Jeffrey N. Weitzel,Marco Montagna,Edith Olah,Andrew K. Godwin,Drakoulis Yannoukakos,David E. Goldgar,Trinidad Caldés,Evgeny N. Imyanitov,Laima Tihomirova,Banu Arun,Ian G. Campbell,Arjen R. Mensenkamp,Christi J. van Asperen,Kees E. P. van Roozendaal,Hanne Meijers-Heijboer,J. Margriet Collée,Jan C. Oosterwijk,Maartje J. Hooning,Matti A. Rookus,Rob B. van der Luijt,Theo A. Mvan Os,D. Gareth Evans,Debra Frost,Elena Fineberg,Julian Barwell,Lisa Walker,M. John Kennedy,Radka Platte,Rosemarie Davidson,Steve Ellis,Trevor Cole,Brigitte Bressac-de Paillerets,Bruno Buecher,Francesca Damiola,Laurence Faivre,Marc Frenay,Olga M. Sinilnikova,Olivier Caron,Sophie Giraud,Sylvie Mazoyer,Valérie Bonadona,Virginie Caux-Moncoutier,Aleksandra Tołoczko-Grabarek,Jacek Gronwald,Tomasz Byrski,Amanda B. Spurdle,Bernardo Bonanni,Daniela Zaffaroni,Giuseppe Giannini,Loris Bernard,Riccardo Dolcetti,Siranoush Manoukian,Norbert Arnold,Christoph Engel,Helmut Deissler,Kerstin Rhiem,Dieter Niederacher,Hansjoerg Plendl,Christian Sutter,Barbara Wappenschmidt,Åke Borg,Beatrice Melin,Johanna Rantala,Maria Soller,Katherine L. Nathanson,Susan M. Domchek,Gustavo C. Rodriguez,Ritu Salani,Daphne Gschwantler Kaulich,Muy Kheng Tea,Shani Shimon Paluch,Yael Laitman,Anne-Bine Skytte,Torben A Kruse,Uffe Birk Jensen,Mark E. Robson,Anne-Marie Gerdes,Bent Ejlertsen,Lenka Foretova,Sharon A. Savage,Jenny Lester,Penny Soucy,Karoline Kuchenbaecker,Curtis Olswold,Julie M. Cunningham,Susan L. Slager,Vernon S. Pankratz,Ed Dicks,Sunil R. Lakhani,Sunil R. Lakhani,Fergus J. Couch,Per Hall,Alvaro N.A. Monteiro,Simon A. Gayther,Paul D.P. Pharoah,Roger R. Reddel,Roger R. Reddel,Ellen L. Goode,Mark H. Greene,Douglas F. Easton,Andrew Berchuck,Antonis C. Antoniou,Georgia Chenevix-Trench,Alison M. Dunning +455 more
TL;DR: Using the Illumina custom genotyping array iCOGs, SNPs at the TERT locus in breast, ovarian and BRCA1 mutation carrier cancer cases and controls and leukocyte telomere measurements are analyzed to find associations cluster into three independent peaks.
Journal ArticleDOI
Prediction of Breast Cancer Risk Based on Profiling With Common Genetic Variants
Nasim Mavaddat,Paul D.P. Pharoah,Kyriaki Michailidou,Jonathan Tyrer,Mark N. Brook,Mark N. Brook,Manjeet K. Bolla,Qin Wang,Joe Dennis,Alison M. Dunning,Mitul Shah,Robert Luben,Judith E. Brown,Stig E. Bojesen,Børge G. Nordestgaard,Sune F. Nielsen,Henrik Flyger,Kamila Czene,Hatef Darabi,Mikael Eriksson,Julian Peto,Isabel dos-Santos-Silva,Frank Dudbridge,Nichola Johnson,Marjanka K. Schmidt,Annegien Broeks,Senno Verhoef,Emiel J. Th. Rutgers,Anthony J. Swerdlow,Alan Ashworth,Nick Orr,Minouk J. Schoemaker,Jonine D. Figueroa,Stephen J. Chanock,Louise A. Brinton,Jolanta Lissowska,Fergus J. Couch,Janet E. Olson,Celine M. Vachon,Vernon S. Pankratz,Diether Lambrechts,Diether Lambrechts,Hans Wildiers,Chantal Van Ongeval,Erik Van Limbergen,Vessela N. Kristensen,Vessela N. Kristensen,Grethe I. Grenaker Alnæs,Silje Nord,Anne Lise Børresen-Dale,Anne Lise Børresen-Dale,Heli Nevanlinna,Taru A. Muranen,Kristiina Aittomäki,Carl Blomqvist,Jenny Chang-Claude,Anja Rudolph,Petra Seibold,Dieter Flesch-Janys,Peter A. Fasching,Peter A. Fasching,Lothar Haeberle,Arif B. Ekici,Matthias W. Beckmann,Barbara Burwinkel,Barbara Burwinkel,Frederik Marme,Frederik Marme,Andreas Schneeweiss,Andreas Schneeweiss,Christof Sohn,Amy Trentham-Dietz,Polly A. Newcomb,Polly A. Newcomb,Linda Titus,Kathleen M. Egan,David J. Hunter,David J. Hunter,Sara Lindström,Sara Lindström,Rulla M. Tamimi,Peter Kraft,Peter Kraft,Nazneen Rahman,Clare Turnbull,Anthony Renwick,Sheila Seal,Sheila Seal,Jingmei Li,Jianjun Liu,Keith Humphreys,Javier Benitez,Javier Benitez,M. Pilar Zamora,Jose Ignacio Arias Perez,Primitiva Menéndez,Anna Jakubowska,Jan Lubinski,Katarzyna Jaworska-Bieniek,Katarzyna Durda,Natalia Bogdanova,Natalia Bogdanova,Natalia Antonenkova,Thilo Dörk,Hoda Anton-Culver,Susan L. Neuhausen,Argyrios Ziogas,Leslie Bernstein,Peter Devilee,Robert A.E.M. Tollenaar,Caroline M. Seynaeve,Christi J. van Asperen,Angela Cox,Simon S. Cross,Malcolm W.R. Reed,Elza Khusnutdinova,Marina Bermisheva,Marina Bermisheva,Darya Prokofyeva,Zalina Takhirova,Alfons Meindl,Rita K. Schmutzler,Rita K. Schmutzler,Christian Sutter,Rongxi Yang,Rongxi Yang,Peter Schürmann,Michael Bremer,Hans Christiansen,Tjoung Won Park-Simon,Peter Hillemanns,Pascal Guénel,Pascal Guénel,Thérèse Truong,Thérèse Truong,Florence Menegaux,Florence Menegaux,Marie Sanchez,Marie Sanchez,Paolo Radice,Paolo Peterlongo,Siranoush Manoukian,Valeria Pensotti,John L. Hopper,Helen Tsimiklis,Carmel Apicella,Melissa C. Southey,Hiltrud Brauch,Hiltrud Brauch,Hiltrud Brauch,Thomas Brüning,Yon Ko,Yon Ko,Alice J. Sigurdson,Michele M. Doody,Ute Hamann,Diana Torres,Hans Ulrich Ulmer,Asta Försti,Elinor J. Sawyer,Ian Tomlinson,Michael J. Kerin,Nicola Miller,Irene L. Andrulis,Irene L. Andrulis,Julia A. Knight,Gord Glendon,Anna Marie Mulligan,Anna Marie Mulligan,Georgia Chenevix-Trench,Rosemary L. Balleine,Graham G. Giles,Roger L. Milne,Catriona McLean,Annika Lindblom,Sara Margolin,Christopher A. Haiman,Brian E. Henderson,Fredrick R. Schumacher,Loic Le Marchand,Ursula Eilber,Shan Wang-Gohrke,Maartje J. Hooning,Antoinette Hollestelle,Ans M.W. van den Ouweland,Linetta B. Koppert,Jane Carpenter,Christine L. Clarke,Rodney J. Scott,Arto Mannermaa,Vesa Kataja,Veli-Matti Kosma,Jaana M. Hartikainen,Hermann Brenner,Volker Arndt,Christa Stegmaier,Aida Karina Dieffenbach,Robert Winqvist,Katri Pylkäs,Arja Jukkola-Vuorinen,Mervi Grip,Kenneth Offit,Kenneth Offit,Joseph Vijai,Joseph Vijai,Mark E. Robson,Rohini Rau-Murthy,Miriam Dwek,Miriam Dwek,Ruth Swann,Katherine Annie Perkins,Mark S. Goldberg,Mark S. Goldberg,Martine Dumont,Diana Eccles,William J. Tapper,Sajjad Rafiq,Esther M. John,Esther M. John,Alice S. Whittemore,Susan L. Slager,Drakoulis Yannoukakos,Amanda E. Toland,Song Yao,Wei Zheng,Sandra L. Halverson,Anna González-Neira,G Pita,M. Rosario Alonso,Nuria Álvarez,Daniel Herrero,Daniel C. Tessier,Daniel Vincent,Francois Bacot,Craig Luccarini,Caroline Baynes,Shahana Ahmed,Mel Maranian,Catherine S. Healey,Jacques Simard,Per Hall,Douglas F. Easton,Montserrat Garcia-Closas +242 more
TL;DR: The PRS stratifies breast cancer risk in women both with and without a family history of breast cancer, and the observed level of risk discrimination could inform targeted screening and prevention strategies.
Journal ArticleDOI
Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk
Fergus J. Couch,Xianshu Wang,Lesley McGuffog,Andy C. H. Lee,Curtis Olswold,Karoline Kuchenbaecker,Penny Soucy,Zachary S. Fredericksen,Daniel Barrowdale,Joe Dennis,Mia M. Gaudet,Ed Dicks,Matthew L. Kosel,Sue Healey,Olga M. Sinilnikova,Adam M. Lee,Francois Bacot,Daniel Vincent,Frans B. L. Hogervorst,Susan Peock,Dominique Stoppa-Lyonnet,Anna Jakubowska,Paolo Radice,Rita K. Schmutzler,Susan M. Domchek,Marion Piedmonte,Christian F. Singer,Eitan Friedman,Mads Thomassen,Thomas Hansen,Susan L. Neuhausen,Csilla Szabo,Ignacio Blanco,Mark H. Greene,Beth Y. Karlan,Judy Garber,Catherine M. Phelan,Jeffrey N. Weitzel,Marco Montagna,Edith Olah,Irene L. Andrulis,Andrew K. Godwin,Drakoulis Yannoukakos,David E. Goldgar,Trinidad Caldés,Heli Nevanlinna,Ana Osorio,Mary Beth Terry,Mary B. Daly,Elizabeth J. van Rensburg,Ute Hamann,Susan J. Ramus,Amanda E. Toland,Maria A. Caligo,Olufunmilayo I. Olopade,Nadine Tung,Kathleen Claes,Mary S. Beattie,Melissa C. Southey,Evgeny N. Imyanitov,Marc Tischkowitz,Ramunas Janavicius,Esther M. John,Ava Kwong,Orland Diez,Judith Balmaña,Rosa B. Barkardottir,Banu Arun,Gad Rennert,Soo Hwang Teo,Patricia A. Ganz,Ian G. Campbell,Annemarie H. van der Hout,Carolien H.M. van Deurzen,Caroline Seynaeve,Encarna B. Gomez Garcia,Flora E. van Leeuwen,Hanne Meijers-Heijboer,Johannes J. P. Gille,Margreet G. E. M. Ausems,Marinus J. Blok,Marjolijn J. L. Ligtenberg,Matti A. Rookus,Peter Devilee,Senno Verhoef,Theo A. M. van Os,Juul T. Wijnen,Debra Frost,Steve Ellis,Elena Fineberg,Radka Platte,D. Gareth Evans,Louise Izatt,Rosalind A. Eeles,Julian Adlard,Diana Eccles,Jackie Cook,Carole Brewer,Fiona Douglas,Shirley Hodgson,Patrick J. Morrison,Lucy Side,Alan Donaldson,C. E. Houghton,Mark T. Rogers,Huw Dorkins,Jacqueline Eason,Helen Gregory,Emma McCann,Alex Murray,Alain Calender,Agnès Hardouin,Pascaline Berthet,Capucine Delnatte,Catherine Noguès,Christine Lasset,Claude Houdayer,Dominique Leroux,Etienne Rouleau,Fabienne Prieur,Francesca Damiola,Hagay Sobol,Isabelle Coupier,Laurence Venat-Bouvet,Laurent Castera,Marion Gauthier-Villars,Mélanie Léoné,Pascal Pujol,Sylvie Mazoyer,Yves-Jean Bignon,Elżbieta Złowocka-Perłowska,Jacek Gronwald,Jan Lubinski,Katarzyna Durda,Katarzyna Jaworska,Tomasz Huzarski,Amanda B. Spurdle,Alessandra Viel,Bernard Peissel,Bernardo Bonanni,Giulia Melloni,Laura Ottini,Laura Papi,Liliana Varesco,Maria Grazia Tibiletti,Paolo Peterlongo,Sara Volorio,Siranoush Manoukian,Valeria Pensotti,Norbert Arnold,Christoph Engel,Helmut Deissler,Dorothea Gadzicki,Andrea Gehrig,Karin Kast,Kerstin Rhiem,Alfons Meindl,Dieter Niederacher,Nina Ditsch,Hansjoerg Plendl,Sabine Preisler-Adams,Stefanie Engert,Christian Sutter,Raymonda Varon-Mateeva,Barbara Wappenschmidt,Bernhard H. F. Weber,Brita Arver,Marie Stenmark-Askmalm,Niklas Loman,Richard Rosenquist,Zakaria Einbeigi,Katherine L. Nathanson,Timothy R. Rebbeck,Stephanie V. Blank,David E. Cohn,Gustavo C. Rodriguez,Laurie Small,Michael Friedlander,Victoria L. Bae-Jump,Anneliese Fink-Retter,Christine Rappaport,Daphne Gschwantler-Kaulich,Georg Pfeiler,Muy-Kheng Tea,Noralane M. Lindor,Bella Kaufman,Shani Shimon Paluch,Yael Laitman,Anne-Bine Skytte,Anne-Marie Gerdes,Inge Søkilde Pedersen,Sanne Traasdahl Moeller,Torben A Kruse,Uffe Birk Jensen,Joseph Vijai,Kara Sarrel,Mark E. Robson,Noah D. Kauff,Anna Marie Mulligan,Gord Glendon,Hilmi Ozcelik,Bent Ejlertsen,Finn Cilius Nielsen,Lars Jønson,Mette K. Andersen,Yuan Chun Ding,Linda Steele,Lenka Foretova,Alex Teulé,Conxi Lázaro,Joan Brunet,Miquel Angel Pujana,Phuong L. Mai,Jennifer T. Loud,Christine Walsh,Jenny Lester,Sandra Orsulic,Steven A. Narod,Josef Herzog,Sharon Sand,Silvia Tognazzo,Simona Agata,Tibor Vaszko,JoEllen Weaver,Alexandra V. Stavropoulou,Saundra S. Buys,Atocha Romero,Miguel de la Hoya,Kristiina Aittomäki,Taru A. Muranen,Mercedes Durán,Wendy K. Chung,Adriana Lasa,Cecilia M. Dorfling,Alexander Miron,Javier Benitez,Leigha Senter,Dezheng Huo,Salina B. Chan,Anna P. Sokolenko,Jocelyne Chiquette,Laima Tihomirova,Tara M. Friebel,Bjarni A. Agnarsson,Karen H. Lu,Flavio Lejbkowicz,Paul A. James,Per Hall,Alison M. Dunning,Daniel C. Tessier,Julie M. Cunningham,Susan L. Slager,Chen Wang,Steven N. Hart,Kristen N. Stevens,Jacques Simard,Tomi Pastinen,Vernon S. Pankratz,Kenneth Offit,Douglas F. Easton,Georgia Chenevix-Trench,Antonis C. Antoniou +261 more
TL;DR: It is estimated that the breast cancer lifetime risks for the5% of BRCA1 carriers at lowest risk are 28%–50% compared to 81%–100% for the 5% at highest risk, and the ovarian cancer lifetime risk is 63% or higher, based on the known cancer risk-modifying loci.
Journal ArticleDOI
Breast Cancer Risk Genes - Association Analysis in More than 113,000 Women
Leila Dorling,Sara Carvalho,Jamie Allen,Anna González-Neira,Craig Luccarini,Cecilia Wahlström,Karen A. Pooley,Michael T. Parsons,Cristina Fortuno,Qin Wang,Manjeet K. Bolla,Joe Dennis,Renske Keeman,M. Rosario Alonso,Nuria Álvarez,Belen Herraez,Victoria Fernández,Rocio Núñez-Torres,Ana Osorio,Jeanette Valcich,Minerva Li,Therese Törngren,Patricia Harrington,Caroline Baynes,Don M. Conroy,Brennan Decker,Laura Fachal,Nasim Mavaddat,Thomas U. Ahearn,Kristiina Aittomäki,Natalia Antonenkova,Norbert Arnold,Patrick Arveux,Margreet G. E. M. Ausems,Päivi Auvinen,Heiko Becher,Matthias W. Beckmann,Sabine Behrens,Marina Bermisheva,Katarzyna Białkowska,Carl Blomqvist,Natalia Bogdanova,Nadja Bogdanova-Markov,Stig E. Bojesen,Bernardo Bonanni,Anne Lise Børresen-Dale,Hiltrud Brauch,Michael Bremer,Ignacio Briceño,Thomas Brüning,Barbara Burwinkel,David Cameron,Nicola J. Camp,Archie Campbell,Angel Carracedo,Jose E. Castelao,Melissa H. Cessna,Stephen J. Chanock,Hans Christiansen,J. Margriet Collée,Emilie Cordina-Duverger,Sten Cornelissen,Kamila Czene,Thilo Dörk,Arif B. Ekici,Christoph Engel,Mikael Eriksson,Peter A. Fasching,Jonine D. Figueroa,Henrik Flyger,Asta Försti,Marike Gabrielson,Manuela Gago-Dominguez,Vassilios Georgoulias,Fabián Gil,Graham G. Giles,Gord Glendon,Encarna B. Gomez Garcia,Grethe I. Grenaker Alnæs,Pascal Guénel,Andreas Hadjisavvas,Lothar Haeberle,Eric Hahnen,Per Hall,Ute Hamann,Elaine F. Harkness,Jaana M. Hartikainen,Mikael Hartman,Wei He,Bernadette A M Heemskerk-Gerritsen,Peter Hillemanns,Frans B. L. Hogervorst,Antoinette Hollestelle,Weang Kee Ho,Maartje J. Hooning,Anthony Howell,Keith Humphreys,Faiza Idris,Anna Jakubowska,Audrey Y. Jung,Pooja Middha Kapoor,Michael J. Kerin,Elza Khusnutdinova,Sung-Won Kim,Yon-Dschun Ko,Veli-Matti Kosma,Vessela N. Kristensen,Kyriacos Kyriacou,Inge M. M. Lakeman,Jong Won Lee,Min Hyuk Lee,Jingmei Li,Annika Lindblom,Wing-Yee Lo,Maria A. Loizidou,Artitaya Lophatananon,Jan Lubinski,Robert J. MacInnis,Michael J. Madsen,Arto Mannermaa,Mehdi Manoochehri,Siranoush Manoukian,Sara Margolin,Maria Elena Martinez,Tabea Maurer,Dimitrios Mavroudis,Catriona McLean,Alfons Meindl,Arjen R. Mensenkamp,Kyriaki Michailidou,Nicola Miller,Nur Aishah Taib,Kenneth Muir,Anna Marie Mulligan,Heli Nevanlinna,William G. Newman,Børge G. Nordestgaard,Pei-Sze Ng,Jan C. Oosterwijk,Sue K. Park,Tjoung-Won Park-Simon,Jose Ignacio Arias Perez,Paolo Peterlongo,David J. Porteous,Karolina Prajzendanc,Darya Prokofyeva,Paolo Radice,Muhammad Usman Rashid,Valerie Rhenius,Matti A. Rookus,Thomas Rüdiger,Emmanouil Saloustros,Elinor J. Sawyer,Rita K. Schmutzler,Andreas Schneeweiss,Peter Schürmann,Mitul Shah,Christof Sohn,Melissa C. Southey,Harald Surowy,Maija Suvanto,Somchai Thanasitthichai,Ian Tomlinson,Diana Torres,Thérèse Truong,Maria Tzardi,Yana Valova,Christi J. van Asperen,Rob M. van Dam,Ans M.W. van den Ouweland,Lizet E. van der Kolk,Elke M van Veen,Camilla Wendt,Justin A. Williams,Xiaohong R. Yang,Sook-Yee Yoon,M. Pilar Zamora,D. Gareth Evans,Miguel de la Hoya,Jacques Simard,Antonis C. Antoniou,Åke Borg,Irene L. Andrulis,Jenny Chang-Claude,Montserrat Garcia-Closas,Georgia Chenevix-Trench,Roger L. Milne,Paul D.P. Pharoah,Marjanka K. Schmidt,Amanda B. Spurdle,Maaike P.G. Vreeswijk,Javier Benitez,Alison M. Dunning,Anders Kvist,Soo Hwang Teo,Peter Devilee,Douglas F. Easton +196 more
TL;DR: The results of this study define the genes that are most clinically useful for inclusion on panels for the prediction of breast cancer risk, as well as provide estimates of the risks associated with protein-truncating variants, to guide genetic counseling.